Drug Metabolism Letters


Zhiyang Zhao
Alliance Pharma
Malvern, PA


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Volume:10   Issue: 2
Pp: 71-71
Mert Ulgen
DOI: 10.2174/187231281002160614161435

Commentary: A Myriad Aberrations on Information of Ontogeny of Drug Metabolizing Enzymes in the Pediatric Population: An Obstacle for Personalizing Drug Therapy in the Pediatric Population open access plus

Volume:10   Issue: 2
Pp: 72-74
Chakradhara Rao S. Uppugunduri and Marc Ansari
DOI: 10.2174/1872312810666160224143443

The Effects of Statin Therapy on the Human Airway

Volume:10   Issue: 2
Pp: 75-82
Lorraine Thong, John MacSharry and Desmond M. Murphy
DOI: 10.2174/1872312810666160303112012

Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability open access plus

Volume:10   Issue: 2
Pp: 83-90
Samantha J. Richardson, April Bai, Ashutosh A. Kulkarni and Mehran F. Moghaddam
DOI: 10.2174/1872312810666160223121836

Rate-Determining and Rate-Limiting Steps in the Clearance and Excretion of a Potent and Selective p21-Activated Kinase Inhibitor: A Case Study of Rapid Hepatic Uptake and Slow Elimination in Rat open access plus

Volume:10   Issue: 2
Pp: 91-100
Peter W. Fan, Jacob Z. Chen, M. Allan Jaochico, Hank La, Ning Liu, Teresa Mulder, Robert T. Cass, Matthew Durk, Kirsten Messick, Nicole Valle, Shannon Liu, Wendy Lee, James J. Crawford, Joachim Rudolf, Lesley J. Murray, S. Cyrus Khojasteh and Matthew Wright
DOI: 10.2174/1872312810666160411144358

In Vitro Study of UGT Metabolism and Permeability of Orientin and Isoorientin, Two Active flavonoid C-glycosides

Volume:10   Issue: 2
Pp: 101-110
Jian Shi, Lijun Zhu, Ye Li, Haihui Zheng, Jia Yu, Linlin Lu and Zhongqiu Liu
DOI: 10.2174/1872312810666160219121217

Biotransformation of Cobicistat: Metabolic Pathways and Enzymes

Volume:10   Issue: 2
Pp: 111-123
Pengcheng Wang, Amina I. Shehu, Ke Liu, Jie Lu and Xiaochao Ma
DOI: 10.2174/1872312810666160303112212

In Vitro CYP2D Inhibitory Effect and Influence on Pharmacokinetics and Pharmacodynamic Parameters of Metoprolol Succinate by Terminalia arjuna in Rats

Volume:10   Issue: 2
Pp: 124-135
Alice Varghese, Jay Savai, Shruti Mistry, Preeti Khandare, Kalyani Barve, Nancy Pandita and Ram Gaud
DOI: 10.2174/1872312810666160219121415

Elucidating the Mechanism of Tofacitinib Oxidative Decyanation

Volume:10   Issue: 2
Pp: 136-143
Hoa Le, Peter W. Fan, Susan Wong, Shuguang Ma, James P. Driscoll, Cornelis E.C.A. Hop and S. Cyrus Khojasteh
DOI: 10.2174/1872312810666160427104954

Formation of A Novel Purine Metabolite through CYP3A4 Bioactivation and Glutathione Conjugation open access plus

Volume:10   Issue: 2
Pp: 144-150
Julius L. Apuy, Cathie Xiang, Sarah Franc, Sayee G. Hegde, Robert Hubbard, Jingjing Zhao and Mehran F. Moghaddam
DOI: 10.2174/1872312810666160511150558