Abstract
Acridine derivatives are one of the oldest classes of bioactives, widely used as antibacterial and antiprotozoal agents. Some work in these areas continues, but recent research has focused mainly on their use as anticancer drugs, because of the ability of the acridine chromophore to intercalate DNA and inhibit topoisomerase enzymes.
Keywords: acridine, chemotherapeutic agents, antibacterial, anticancer drugs, charge-transfer interactions, mode of binding, kinetics, high therapeutic indices, human breast cancer cell lines, efficient mutagen
Current Medicinal Chemistry
Title: Acridine Derivatives as Chemotherapeutic Agents
Volume: 9 Issue: 18
Author(s): William A. Denny
Affiliation:
Keywords: acridine, chemotherapeutic agents, antibacterial, anticancer drugs, charge-transfer interactions, mode of binding, kinetics, high therapeutic indices, human breast cancer cell lines, efficient mutagen
Abstract: Acridine derivatives are one of the oldest classes of bioactives, widely used as antibacterial and antiprotozoal agents. Some work in these areas continues, but recent research has focused mainly on their use as anticancer drugs, because of the ability of the acridine chromophore to intercalate DNA and inhibit topoisomerase enzymes.
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Cite this article as:
Denny A. William, Acridine Derivatives as Chemotherapeutic Agents, Current Medicinal Chemistry 2002; 9 (18) . https://dx.doi.org/10.2174/0929867023369277
DOI https://dx.doi.org/10.2174/0929867023369277 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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