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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Rapid Determination of Pharmacokinetic Properties of New Chemical Entities: In vivo Approaches

Author(s): Kathleen A. Cox, Ronald E. White and Walter A. Korfmacher

Volume 5, Issue 1, 2002

Page: [29 - 37] Pages: 9

DOI: 10.2174/1386207023330534

Price: $65

Abstract

There is a continuing need for increased throughput in the evaluation of new chemical entities in terms of their pharmacokinetic (PK) parameters as part of new drug discovery. This review summarizes various approaches that have been used to increase throughput in this area. The article divides the approaches into two areas: assay enhancement and sample reduction.

Keywords: Pharmacokinetic pk, drug discovery, solid phase extraction spe


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