Abstract
Breast cancers are highly variable with regard to pathological and clinical features. While various different cancers being at different stages of tumor progression might explain some of this variability, we must also consider evidence that breast cancers can also develop along different molecular pathways. This manuscript discusses the extensive heterogeneity of breast cancer at the pathological and molecular level, reviewing evidence for a breast cancer progression model as well as evidence that breast cancer is not a single disease. In addition to this heterogeneity among different breast cancers, there is often pathological and molecular heterogeneity among different areas within individual neoplasms. This heterogeneity within cancers probably reflects genetic instability, and could also explain the ability of breast cancers to adapt to new environmental situations. Understanding this heterogeneity, among different breast cancers as well as within individual cancers, is important for understanding the complexity of this disease and ultimately for managing breast cancer effectively.
Current Genomics
Title: Heterogeneity in the Pathology and Molecular Biology of Breast Cancer
Volume: 3 Issue: 5
Author(s): Edward Gabrielson and Pedram Argani
Affiliation:
Abstract: Breast cancers are highly variable with regard to pathological and clinical features. While various different cancers being at different stages of tumor progression might explain some of this variability, we must also consider evidence that breast cancers can also develop along different molecular pathways. This manuscript discusses the extensive heterogeneity of breast cancer at the pathological and molecular level, reviewing evidence for a breast cancer progression model as well as evidence that breast cancer is not a single disease. In addition to this heterogeneity among different breast cancers, there is often pathological and molecular heterogeneity among different areas within individual neoplasms. This heterogeneity within cancers probably reflects genetic instability, and could also explain the ability of breast cancers to adapt to new environmental situations. Understanding this heterogeneity, among different breast cancers as well as within individual cancers, is important for understanding the complexity of this disease and ultimately for managing breast cancer effectively.
Export Options
About this article
Cite this article as:
Gabrielson Edward and Argani Pedram, Heterogeneity in the Pathology and Molecular Biology of Breast Cancer, Current Genomics 2002; 3 (5) . https://dx.doi.org/10.2174/1389202023350327
DOI https://dx.doi.org/10.2174/1389202023350327 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Advanced Computational Algorithms and Artificial Intelligence in Clinical Pharmacogenomics
In the era of personalized medicine, understanding the relationship between genetics and drug response is crucial. This issue delves into innovative methodologies, leveraging deep computational analysis and artificial intelligence, to enhance the field of Clinical Pharmacogenomics. The interdisciplinary approach harnesses the power of advanced high-throughput genotyping technologies, sophisticated computational analysis, ...read more
Applications of Single-cell Sequencing Technology in Reproductive Medicine
Single cell sequencing (SCS) technology utilizes individual cells' genetic material to sequence their genome, transcriptome, and epigenetics at the molecular level. It offers insights into cell heterogeneity and enables the study of limited biological materials. Since its recognition as a valuable technique in 2011, single cell sequencing has yielded numerous ...read more
Big Data in Cancer Research
Cancer is a significant threat to human life and health, remaining a highly aggressive killer. It is a leading cause of death worldwide and represents a crucial medical issue for humanity. However, in the past decade, the effectiveness of new synthetic anticancer agents has not matched the current clinical speculation. ...read more
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Role of Mitochondrial Heat-shock Proteins and Immunophilins in Neuro Degenerative Diseases
Current Drug Targets The Development of a Rapid, Simple and Sensitive LC-MS/MS Method, to Guide Clinical Dosing, for the Analysis of 5-Fluorouracil in Human Plasma
Current Pharmaceutical Analysis Proteins as Alternate Targets of Enediynes
Letters in Drug Design & Discovery Gender Differences in Metabolic Syndrome – A Key Research Issue
Endocrine, Metabolic & Immune Disorders - Drug Targets Editorial: Targeting Neuregulin1 and HER Receptor Tyrosine Kinases for Therapy of Breast Cancer and Heart Failure
Current Pharmaceutical Design PET Imaging of Multidrug Resistance in Tumors Using 18F-Fluoropaclitaxel
Current Topics in Medicinal Chemistry Palladium-Catalyzed Oxyarylation, Azaarylation and α-Arylation Reactions in the Synthesis of Bioactive Isoflavonoid Analogues
Current Organic Synthesis Biomedical Applications of Natural Polymers for Drug Delivery
Current Organic Chemistry QSAR Study of Androstenedione Analogs as Aromatase Inhibitors
Letters in Drug Design & Discovery Inflammation in Neurodegenerative Disorders: Friend or Foe?
Current Aging Science Research Advances in Neuroblastoma Immunotherapy
Current Pediatric Reviews Novel Indications for Benzodiazepine Antagonist Flumazenil in GABA Mediated Pathological Conditions of the Central Nervous System
Current Pharmaceutical Design Design and Synthesis of Novel Antineoplastic Agents Inspired from Marine Bromopyrrole Alkaloids
Anti-Cancer Agents in Medicinal Chemistry Targeting the Ubiquitin-Proteasome Pathway in Cancer Therapy
Anti-Cancer Agents in Medicinal Chemistry Exploring the Unexplored Practical and Alternative Synthesis of 3- (Trifluoromethyl)-Triazolopiperazine the Key Intermediate for Sitagliptin
Letters in Organic Chemistry Recent Advances in Chalcone-Based Anticancer Heterocycles: A Structural and Molecular Target Perspective
Current Medicinal Chemistry Biology of Cox-2: An Application in Cancer Therapeutics
Current Drug Targets Preclinical Development of New Therapy for Glycogen Storage Diseases
Current Gene Therapy Structure Guided Molecular Docking Assisted Alignment Dependent 3DQSAR Study on Steroidal Aromatase Inhibitors (SAIs) as Anti-breast Cancer Agents
Letters in Drug Design & Discovery Antitumor Potential and Possible Targets of Phenothiazine-Related Compounds
Current Drug Targets