CNS & Neurological Disorders - Drug Targets

(Formerly Current Drug Targets - CNS & Neurological Disorders)

Editor-in-Chief:

Cesar V. Borlongan
Department of Neurosurgery and Brain Repair
University of South Florida Morsani College of Medicine
Tampa, FL
USA

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Open Access Articles

Physiological and Morphological Principles Underpinning Recruitment of the Cerebellar Reserve open Access plus

Volume: 17   Issue: 3
Pp: 184-192
Shinji Kakei*, Takahiro Ishikawa, Jongho Lee, Takeru Honda and Donna S. Hoffman
DOI:10.2174/1871527317666180315164429

Demonstration of Biological and Immunological Equivalence of a Generic Glatiramer Acetate open Access plus

Volume: 16   Issue: 6
Pp: 714-723
Josephine D`Alessandro, Kevin Garofalo, Ganlin Zhao, Christopher Honan, Jay Duffner, Ishan Capila, Ian Fier, Ganesh Kaundinya, Daniel Kantor and Tanmoy Ganguly*
DOI:10.2174/1871527316666170223162747

Therapeutic Role of Synaptic Vesicle Glycoprotein 2A (SV2A) in Modulating Epileptogenesis open Access plus

Volume: 16   Issue: 4
Pp: 463-471
Yukihiro Ohno* and Kentaro Tokudome
DOI:10.2174/1871527316666170404115027

Nanomaterials for Neurology: State-of-the-Art open Access plus

Volume: 15   Issue: 10
Pp: 1306-1324
María Fernanda Veloz-Castillo, Rachel M. West, Jessica Cordero-Arreola, Oscar Arias-Carrión and Miguel A. Méndez-Rojas
DOI:10.2174/1871527315666160801144637

The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders open Access plus

Volume: 15   Issue: 5
Pp: 564-577
Yuko Okamoto, Makoto Ishitobi, Yuji Wada and Hirotaka Kosaka
DOI:10.2174/1871527315666160413120845

mTOR, a Potential Target to Treat Autism Spectrum Disorder open Access plus

Volume: 15   Issue: 5
Pp: 533-543
Atsushi Sato
DOI:10.2174/1871527315666160413120638

A Link Between Nerve Growth Factor Metabolic Deregulation and Amyloid-β-Driven Inflammation in Down Syndrome open Access plus

Volume: 15   Issue: 4
Pp: 434-447
Maria Florencia Iulita, Filippo Caraci and Augusto Claudio Cuello
DOI:10.2174/1871527315666160321104916

Novel Lactulose and Melibiose Targeting Autophagy to Reduce PolyQ Aggregation in Cell Models of Spinocerebellar Ataxia 3 open Access plus

Volume: 15   Issue: 3
Pp: 351-359
Chih-Hsin Lin, Yih-Ru Wu, Jinn-Moon Yang, Wan-Ling Chen, Chih-Ying Chao, I-Cheng Chen, Te-Hsien Lin, Yi-Ci Wu, Kai-Cheng Hsu, Chiung-Mei Chen, Guan-Chiun Lee, Hsiu-Mei Hsieh-Li, Chi-Mei Lee and Guey-Jen Lee-Chen
DOI:10.2174/1871527314666150821101522

The Effects of Testosterone Supplementation on Cognitive Functioning in Older Men. open Access plus

Volume: 15   Issue: 3
Pp: 337-343
Eka J. Wahjoepramono, Prita R. Asih, Vilia Aniwiyanti, Kevin Taddei, Satvinder S. Dhaliwal, Stephanie J. Fuller, Jonathan Foster, Malcolm Carruthers, Giuseppe Verdile, Hamid R Sohrabi and Ralph N. Martins
DOI:10.2174/1871527315666151110125704

Ouabain-Induced Signaling and Cell Survival in SK-N-SH Neuroblastoma Cells Differentiated by Retinoic Acid open Access plus

Volume: 14   Issue: 10
Pp: 1343-1349
Evgeny E. Akkuratov, Jian Wu, David Sowa, Zahoor A. Shah and Lijun Liu
DOI:10.2174/1871527314666150821103008

Exploring the Role of Nerve Growth Factor in Multiple Sclerosis: Implications in Myelin Repair open Access plus

Volume: 12   Issue: 8
Pp: 1242-1256
C.M.R. Acosta, C. Cortes, H. MacPhee and M.P. Namaka
DOI:10.2174/18715273113129990087

Contribution of Glucocorticoids and Glucocorticoid Receptors to the Regulation of Neurodegenerative Processes open Access plus

Volume: 12   Issue: 8
Pp: 1175-1193
Sheela Vyas and Layal Maatouk
DOI:10.2174/187152731131200125

The Role of Neuroimaging in Our Understanding of the Suicidal Brain open Access plus

Volume: 12   Issue: 7
Pp: 921-929
Stefanie Desmyter, Stijn Bijttebier and Kees van Heeringen
DOI:10.2174/18715273113129990093

Motor Complications in Parkinson’s Disease: A Comprehensive Review of Emergent Management Strategies open Access plus

Volume: 12   Issue: 7
Pp: 1017-1049
Susana Marques de Sousa and João Massano
DOI:10.2174/18715273113129990086

Relationship Between the Chemokine Receptor CCR5 and Microglia in Neurological Disorders: Consequences of Targeting CCR5 on Neuroinflammation, Neuronal Death and Regeneration in a Model of Epilepsy open Access plus

Volume: 12   Issue: 6
Pp: 815-829
Jean-Pierre Louboutin and David S. Strayer
DOI:10.2174/18715273113126660173

Glutamate Receptors in Microglia open Access plus

Volume: 12   Issue: 6
Pp: 773-784
Madhuvika Murugan, Eng-Ang Ling and Charanjit Kaur
DOI:10.2174/18715273113126660174

Nicotinic Receptors as Therapeutic Targets for Drug Addictive Disorders open Access plus

Volume: 12   Issue: 5
Pp: 633-640
Shafiqur Rahman
DOI:10.2174/1871527311312050011

mGlu2/3 Agonist-Induced Hyperthermia: An In Vivo Assay for Detection of mGlu2/3 Receptor Antagonism and its Relation to Antidepressant-Like Efficacy in Mice open Access plus

Volume: 12   Issue: 5
Pp: 554-566
S.D. Gleason, X. Li, I.A. Smith, J.D. Ephlin, X-S. Wang, B. A. Heinz, J.H. Carter, M. Baez, J. Yu, D.M. Bender and J.M. Witkin
DOI:10.2174/18715273113129990079

Frailty Among Alzheimer’s Disease Patients open Access plus

Volume: 12   Issue: 4
Pp: 507-511
Giacomo Koch, Lorena Belli, Temistocle Lo Giudice, Francesco Di Lorenzo, Giulia Maria Sancesario, Roberto Sorge, Sergio Bernardini and Alessandro Martorana
DOI:10.2174/1871527311312040010

Curcumin, an Active Constiuent of the Ancient Medicinal Herb Curcuma longa L.: Some Uses and the Establishment and Biological Basis of Medical Efficacy open Access plus

Volume: 12   Issue: 4
Pp: 487-497
Jeffrey M. Witkin and Xia Li
DOI:10.2174/1871527311312040007

Neurorestorative Effect of Urinary Bladder Matrix-Mediated Neural Stem Cell Transplantation Following Traumatic Brain Injury in Rats open Access plus

Volume: 12   Issue: 3
Pp: 413-425
J.Y. Wang, A.K.F. Liou, Z.H. Ren, L. Zhang, B.N. Brown, X.T. Cui, S.F. Badylak, Y.N. Cai, Y.Q. Guan, Rehana K. Leak, J. Chen, X. Ji and L. Chen
DOI:10.2174/1871527311312030014

HSP27 Protects the Blood-Brain Barrier Against Ischemia-Induced Loss of Integrity open Access plus

Volume: 12   Issue: 3
Pp: 325-337
Rehana K. Leak, Lili Zhang, R. Anne Stetler, Zhongfang Weng, Peiying Li, G. Brandon Atkins, Yanqin Gao and Jun Chen
DOI:10.2174/1871527311312030006

TRP Channels: New Potential Therapeutic Approaches in CNS Neuropathies open Access plus

Volume: 12   Issue: 2
Pp: 274-293
Maria Beatrice Morelli, Consuelo Amantini, Sonia Liberati, Matteo Santoni and Massimo Nabissi
DOI:10.2174/18715273113129990056

Lipoxygenase: An Emerging Target for Stroke Therapy open Access plus

Volume: 12   Issue: 2
Pp: 191-199
Klaus van Leyen
DOI:10.2174/18715273112119990053

Effects of α-Synuclein Overexpression in Transgenic Caenorhabditis elegans Strains open Access plus

Volume: 11   Issue: 8
Pp: 965-975
Rakesh Bodhicharla, Archana Nagarajan, Jody Winter, Ademola Adenle, Aamir Nazir, Declan Brady, Kelly Vere, Jo Richens, Paul O’Shea, David R. Bell and David de Pomerai
DOI:10.2174/1871527311211080005

Nuclear Factor Erythroid 2 - Related Factor 2 Signaling in Parkinson Disease: A Promising Multi Therapeutic Target Against Oxidative Stress, Neuroinflammation and Cell Death open Access plus

Volume: 11   Issue: 8
Pp: 1015-1029
Hemant Kumar, Sushruta Koppula, In-Su Kim, Sandeep Vasant More, Byung-Wook Kim and Dong-Kug Choi
DOI:10.2174/1871527311211080012

Pitx2 Expression Promotes p21 Expression and Cell Cycle Exit in Neural Stem Cells open Access plus

Volume: 11   Issue: 7
Pp: 884-892
Nina Heldring, Bertrand Joseph, Ola Hermanson and Chrissa Kioussi
DOI:10.2174/1871527311201070884

Neurovascular Signals Suggest a Propagation Mechanism for Endogenous Stem Cell Activation Along Blood Vessels open Access plus

Volume: 11   Issue: 7
Pp: 805-817
Jimmy Masjkur, Maria Adele Rueger, Stefan R. Bornstein, Ron McKay and Andreas Androutsellis-Theotokis
DOI:10.2174/1871527311201070805

Purinergic Signalling: What is Missing and Needed Next? The Use of Transgenic Mice, Crystallographic Analysis and MicroRNA open Access plus

Volume: 11   Issue: 6
Pp: 751-767
C. Volonte, C. Parisi and G. Burnstock
DOI:10.2174/187152712803581146

P2Y Receptors in the Mammalian Nervous System: Pharmacology, Ligands and Therapeutic Potential open Access plus

Volume: 11   Issue: 6
Pp: 722-738
Gary A. Weisman, Lucas T. Woods, Laurie Erb and Cheikh I. Seye
DOI:10.2174/187152712803581047

Viruses and Multiple Sclerosis open Access plus

Volume: 11   Issue: 5
Pp: 528-544
Jussi Oskari Virtanen and Steve Jacobson
DOI:10.2174/187152712801661220

Pathology of Multiple Sclerosis open Access plus

Volume: 11   Issue: 5
Pp: 506-517
Markus Kipp, Paul van der Valk and Sandra Amor
DOI:10.2174/187152712801661248

Tyrosine Hydroxylase Gene: Another Piece of the Genetic Puzzle of Parkinson’s Disease open Access plus

Volume: 11   Issue: 4
Pp: 469-481
Guney Bademci, Jeffery M. Vance and Liyong Wang
DOI:10.2174/187152712800792866

Moving Beyond Tyrosine Hydroxylase to Define Dopaminergic Neurons for Use in Cell Replacement Therapies for Parkinson’s Disease open Access plus

Volume: 11   Issue: 4
Pp: 340-349
Robert B. White and Meghan G. Thomas
DOI:10.2174/187152712800792758

The Role of Catechol-O-Methyltransferase in Reward Processing and Addiction open Access plus

Volume: 11   Issue: 3
Pp: 306-323
E. M. Tunbridge, A. Huber, S. M. Farrell, K. Stumpenhorst, P. J. Harrison and M. E. Walton
DOI:10.2174/187152712800672409

The Role of the Catechol-O-Methyltransferase (COMT) Gene in Personality and Related Psychopathological Disorders open Access plus

Volume: 11   Issue: 3
Pp: 236-250
Christian Montag, Magdalena Jurkiewicz and Martin Reuter
DOI:10.2174/187152712800672382

Changes in Cannabinoid Receptor Subtype 1 Activity and Interaction with Metabotropic Glutamate Subtype 5 Receptors in the Periaqueductal Gray- Rostral Ventromedial Medulla Pathway in a Rodent Neuropathic Pain Model open Access plus

Volume: 11   Issue: 2
Pp: 148-161
Enza Palazzo, Livio Luongo, Giulia Bellini, Francesca Guida, Ida Marabese, Serena Boccella, Francesca Rossi, Sabatino Maione and Vito de Novellis
DOI:10.2174/187152712800269731

The Kinetics of Non-Synaptically Triggered Acute Excitotoxic Responses in the Central Nervous System Observed Using Intrinsic Optical Signals open Access plus

Volume: 11   Issue: 2
Pp: 132-141
Vera Maura Fernandes de Lima and Wolfgang Hanke
DOI:10.2174/187152712800269704

Current Options and Future Possibilities for the Treatment of Dyskinesia and Motor Fluctuations in Parkinson's Disease open Access plus

Volume: 10   Issue: 6
Pp: 670-684
M. A. Cenci, K. E. Ohlin and P. Odin
DOI:10.2174/187152711797247885

Prolyl Oligopeptidase, Inositol Phosphate Signalling and Lithium Sensitivity open Access plus

Volume: 10   Issue: 3
Pp: 333-339
Adrian J. Harwood
DOI:10.2174/187152711794653779

Phenotypic Screening Strategies for Neurodegenerative Diseases: A Pathway to Discover Novel Drug Candidates and Potential Disease Targets or Mechanisms open Access plus

Volume: 9   Issue: 6
Pp: 693-700
R. M. Pruss
DOI:10.2174/187152710793237377

Drosophila melanogaster in the Study of Human Neurodegeneration open Access plus

Volume: 9   Issue: 4
Pp: 504-523
Frank Hirth
DOI:10.2174/187152710791556104

NF-κB, a Potential Therapeutic Target for the Treatment of Multiple Sclerosis open Access plus

Volume: 7   Issue: 6
Pp: 536-557
J. Yan and J. M. Greer
DOI:10.2174/187152708787122941

GABAA Receptors, Anesthetics and Anticonvulsants in Brain Development open Access plus

Volume: 7   Issue: 2
Pp: 211-224
Oliver Henschel, Keith E. Gipson and Angelique Bordey
DOI:10.2174/187152708784083812