CNS & Neurological Disorders - Drug Targets

Computational Protein-Protein Docking Reveals the Therapeutic Potential of Kunitz-type Venom against hKv1.2 Binding Sites

Volume: 18   Issue: 5
Pp: 382-404
Rida Khalid, Nighat Noureen, Mohammad Amjad Kamal and Sidra Batool*
DOI: 10.2174/1871527318666190319140204

Grape Seed Proanthocyanidins Protect N2a Cells against Ischemic Injury via Endoplasmic Reticulum Stress and Mitochondrial-associated Pathways

Volume: 18   Issue: 4
Pp: 334-341
Kun Fu, Liqiang Chen, Lifeng Miao*, Yan Guo, Wei Zhang and Yunan Bai*
DOI: 10.2174/1871527318666190212111650

Causes and Consequences of MicroRNA Dysregulation Following Cerebral Ischemia-Reperfusion Injury

Volume: 18   Issue: 3
Pp: 212-221
Fatemeh Forouzanfar, Mana Shojapour, Samira Asgharzade* and Elham Amini
DOI: 10.2174/1871527318666190204104629

Xuesaitong May Protect Against Ischemic Stroke by Modulating Microglial Phenotypes and Inhibiting Neuronal Cell Apoptosis via the STAT3 Signaling Pathway

Volume: 18   Issue: 2
Pp: 115-123
Fangfang Li, Haiping Zhao, Ziping Han, Rongliang Wang, Zhen Tao, Zhibin Fan, Sijia Zhang, Guangwen Li, Zhigang Chen* and Yumin Luo*
DOI: 10.2174/1871527317666181114140340

Motor Recovery after Chronic Spinal Cord Transection in Rats: A Proof-of-Concept Study Evaluating a Combined Strategy

Volume: 18   Issue: 1
Pp: 52-62
Antonio Ibarra*, Erika Mendieta-Arbesú, Paola Suarez-Meade, Elisa García-Vences, Susana Martiñón, Roxana Rodriguez-Barrera, Joel Lomelí, Adrian Flores-Romero, Raúl Silva-García, Vinnitsa Buzoianu-Anguiano, Cesar V. Borlongan and Tamara D. Frydman
DOI: 10.2174/1871527317666181105101756

Models of Parkinson’s Disease with Special Emphasis on Drosophila melanogaster

Volume: 17   Issue: 10
Pp: 757-766
Ambreen Fatima, Smita Jyoti and Yasir Hasan Siddique*
DOI: 10.2174/1871527317666180820164250

Autophagy and Mitochondria: Targets in Neurodegenerative Disorders

Volume: 17   Issue: 9
Pp: 696-705
Ashutosh Kumar*, Amruta Dhawan, Alknanda Kadam and Akshada Shinde
DOI: 10.2174/1871527317666180816100203

Serum Tryptophan, Tryptophan Catabolites and Brain-derived Neurotrophic Factor in Subgroups of Youngsters with Autism Spectrum Disorders

Volume: 17   Issue: 8
Pp: 626-639
Heidi Ormstad*, Vesna Bryn, Robert Verkerk, Ola H. Skjeldal, Bente Halvorsen, Ola Didrik Saugstad, Jorn Isaksen and Michael Maes
DOI: 10.2174/1871527317666180720163221

Light-Emitting Diode (LED) Therapy Attenuates Neurotoxicity of Methanol-Induced Memory Impairment and Apoptosis in The Hippocampus

Volume: 17   Issue: 7
Pp: 528-538
Amir Ghanbari, Kazem Zibara, Sepideh Salari, Majid Ghareghani, Parastou Rad, Wael Mohamed, Elham Ebadi, Mohamad Malekzadeh and Hamdallah Delaviz*
DOI: 10.2174/1871527317666180703111643

Protective Effect of Kaempferol on the Transgenic Drosophila Model of Alzheimer’s Disease

Volume: 17   Issue: 6
Pp: 421-429
Tanveer Beg, Smita Jyoti, Falaq Naz, Rahul, Fahad Ali, Syed Kashif Ali, Ahmed Mohamed Reyad and Yasir Hasan Siddique*
DOI: 10.2174/1871527317666180508123050

Pain-Related Behavior and Brain Activation in a Cynomolgus Macaque Model of Postoperative Pain

Volume: 17   Issue: 5
Pp: 348-360
Aldric Hama*, Takahiro Natsume, Shin`ya Ogawa, Yuji Awaga, Ikuo Hayashi, Akihisa Matsuda and Hiroyuki Takamatsu
DOI: 10.2174/1871527317666180515121350

Cerebrolysin and Aquaporin 4 Inhibition Improve Pathological and Motor Recovery after Ischemic Stroke

Volume: 17   Issue: 4
Pp: 299-308
Bogdan Catalin, Otilia-Constantina Rogoveanu, Ionica Pirici, Tudor Adrian Balseanu, Adina Stan, Valerica Tudorica, Maria Balea, Ion Mindrila, Carmen Valeria Albu, Guleed Mohamed, Daniel Pirici* and Dafin Fior Muresanu
DOI: 10.2174/1871527317666180425124340

N-3 (Omega-3) Fatty Acids: Effects on Brain Dopamine Systems and Potential Role in the Etiology and Treatment of Neuropsychiatric Disorders

Volume: 17   Issue: 3
Pp: 216-232
Michelle Healy-Stoffel and Beth Levant*
DOI: 10.2174/1871527317666180412153612

Inhibition of Neurogenesis by Zika Virus Infection

Volume: 17   Issue: 2
Pp: 78-86
Fahim Ahmad, Amna Siddiqui, Mohammad A. Kamal and Sayed Sartaj Sohrab*
DOI: 10.2174/1871527317666180202115114

Every Cloud Has a Silver Lining: Proneurogenic Effects of Aβ Oligomers and HMGB-1 via Activation of the RAGE-NF-κB Axis

Volume: 16   Issue: 10
Pp: 1066-1079
Valeria Bortolotto and Mariagrazia Grilli*
DOI: 10.2174/1871527315666160803153459

Implications of PEGylation of Carbon Nanotubes for Central Nervous System Bioavailability

Volume: 16   Issue: 9
Pp: 983-989
Gisele Eva Bruch, Marcos F. Cordeiro, Livia S. Gomides, Carolina Peixoto, Arthur P. Cordeiro, Lidiane Dal Bosco, Adelina P. Santos and Daniela M. Barros*
DOI: 10.2174/1871527316666170731111735

Immunomodulatory Strategies for Huntington's Disease Treatment

Volume: 16   Issue: 8
Pp: 936-944
Gabriela D. Colpo*, Natalia P. Rocha, Erin Fur Stimming and Antonio L. Teixeira
DOI: 10.2174/1871527316666170613084801

The Role of Innate Immune System Receptors in Epilepsy Research

Volume: 16   Issue: 7
Pp: 749-762
Jessica Cordero-Arreola, Rachel M. West, Julieta Mendoza-Torreblanca, Edna Mendez-Hernandez, Jose Salas-Pacheco, Manuel Menendez-Gonzalez, Rafael C. Freire, Sergio Machado, Eric Murillo-Rodriguez, Antonio E. Nardi and Oscar Arias-Carrion*
DOI: 10.2174/1871527316666170725145549

Ultra-micronized Palmitoylethanolamide: An Efficacious Adjuvant Therapy for Parkinson’s Disease

Volume: 16   Issue: 6
Pp: 705-713
Stefania Brotini*, Carlo Schievano and Leonello Guidi
DOI: 10.2174/1871527316666170321124949

Metabotropic Glutamate Receptor 7 (mGluR7) as a Target for Modulating Pain-evoked Activities of Neurons in the Hippocampal CA3 Region of Rats

Volume: 16   Issue: 5
Pp: 610-616
Xinya Wei, Dongxiao Yang, Tiefeng Shi, Jianing Wang, Yunling Deng, Xuezhu Qiao, Chunxiao Yang* and Manying Xu*
DOI: 10.2174/1871527315666160801142356

Therapeutic Role of Synaptic Vesicle Glycoprotein 2A (SV2A) in Modulating Epileptogenesis

Volume: 16   Issue: 4
Pp: 463-471
Yukihiro Ohno* and Kentaro Tokudome
DOI: 10.2174/1871527316666170404115027

Mitochondrial Dysfunctions in Bipolar Disorder: Effect of the Disease and Pharmacotherapy

Volume: 16   Issue: 2
Pp: 176-186
Tereza Cikankova, Ekaterina Sigitova, Martina Zverova, Zdenek Fisar, Jiri Raboch and Jana Hroudova
DOI: 10.2174/1871527315666161213110518

Therapeutic Antibodies for Spinal Cord Injury

Volume: 16   Issue: 1
Pp: 51-64
Dan-yang Tang and Wei-jiang Zhao
DOI: 10.2174/1871527315666160915150754

Nanomaterials for Neurology: State-of-the-Art open access plus

Volume: 15   Issue: 10
Pp: 1306-1324
María Fernanda Veloz-Castillo, Rachel M. West, Jessica Cordero-Arreola, Oscar Arias-Carrión and Miguel A. Méndez-Rojas
DOI: 10.2174/1871527315666160801144637

Merging Transport Data for Choroid Plexus with Blood-Brain Barrier to Model CNS Homeostasis and Disease More Effectively

Volume: 15   Issue: 9
Pp: 1151-1180
Conrad Johanson and Nancy Johanson
DOI: 10.2174/1871527315666160915120758

Functions of Ghrelin in Brain, Gut and Liver

Volume: 15   Issue: 8
Pp: 956-963
Cristina Stasi and Stefano Milani
DOI: 10.2174/1871527315666160709203525

Neurobiology of Bipolar Disorder: Abnormalities on Cognitive and Cortical Functioning and Biomarker Levels

Volume: 15   Issue: 6
Pp: 713-722
Alberto S. de Sá, Carlos Campos, Nuno B.F. Rocha, Ti-Fei Yuan, Flávia Paes, Oscar Arias-Carrión, Mauro G. Carta, Antonio E. Nardi, Elie Cheniaux and Sergio Machado
DOI: 10.2174/1871527315666160321111359

Adrenergic Drugs Blockers or Enhancers for Cognitive Decline ? What to Choose for Alzheimer’s Disease Patients?

Volume: 15   Issue: 6
Pp: 665-671
Grazia D. Femminella, Dario Leosco, Nicola Ferrara and Giuseppe Rengo
DOI: 10.2174/1871527315666160518123201

Biomarker-Guided Strategy for Treatment of Autism Spectrum Disorder (ASD)

Volume: 15   Issue: 5
Pp: 602-613
Hua Liu, Paul Talalay and Jed W. Fahey
DOI: 10.2174/1871527315666160413120414

A Link Between Nerve Growth Factor Metabolic Deregulation and Amyloid-β-Driven Inflammation in Down Syndrome

Volume: 15   Issue: 4
Pp: 434-447
Maria Florencia Iulita, Filippo Caraci and Augusto Claudio Cuello
DOI: 10.2174/1871527315666160321104916

Novel Lactulose and Melibiose Targeting Autophagy to Reduce PolyQ Aggregation in Cell Models of Spinocerebellar Ataxia 3

Volume: 15   Issue: 3
Pp: 351-359
Chih-Hsin Lin, Yih-Ru Wu, Jinn-Moon Yang, Wan-Ling Chen, Chih-Ying Chao, I-Cheng Chen, Te-Hsien Lin, Yi-Ci Wu, Kai-Cheng Hsu, Chiung-Mei Chen, Guan-Chiun Lee, Hsiu-Mei Hsieh-Li, Chi-Mei Lee and Guey-Jen Lee-Chen
DOI: 10.2174/1871527314666150821101522

The Co-Metabolism within the Gut-Brain Metabolic Interaction: Potential Targets for Drug Treatment and Design

Volume: 15   Issue: 2
Pp: 127-134
Mark Obrenovich, Rudolf Flückiger, Lorraine Sykes and Curtis Donskey
DOI: 10.2174/1871527315666160202123107

Development of a Novel and Robust Pharmacological Model of Okadaic Acid-induced Alzheimer’s Disease in Zebrafish promotion: free to download

Volume: 15   Issue: 1
Pp: 86-94
Shadia E. Nada, Frederick E. Williams and Zahoor A. Shah
DOI: 10.2174/1871527314666150821105602

Nanoparticles: A Neurotoxicological Perspective

Volume: 14   Issue: 10
Pp: 1317-1327
Anuradha Pandey, Vajir Malek, Visakh Prabhakar, Yogesh Aanat Kulkarni and Anil Bhanudas Gaikwad
DOI: 10.2174/1871527314666150821112411

A Fluorescence Resonance Energy Transfer Assay For Monitoring α- Synclein Aggregation in a Caenorhabditis Elegans Model For Parkinson’s Disease

Volume: 14   Issue: 8
Pp: 1054-1068
Archana Nagarajan, Rakesh Bodhicharla, Jody Winter, Charumathi Anbalagan, Kevin Morgan, Mark Searle, Aamir Nazir, Ademola Adenle, April Fineberg, Declan Brady, Kelly Vere, Jo Richens, Paul O'Shea, David Bell and David de-Pomerai
DOI: 10.2174/1871527314666150821110538

Role of Pituitary Adenylate Cyclase-Activating Polypeptide in Nociception and Migraine

Volume: 14   Issue: 4
Pp: 540-553
Janos Tajti, Bernadett Tuka, Balint Botz, Zsuzsanna Helyes and Laszlo Vecsei
DOI: 10.2174/1871527314666150429114234

TiO2-Nanowired Delivery of Mesenchymal Stem Cells Thwarts Diabetes- Induced Exacerbation of Brain Pathology in Heat Stroke: An Experimental Study in the Rat Using Morphological and Biochemical Approaches

Volume: 14   Issue: 3
Pp: 386-399
Hari S. Sharma, Lianyuan Feng, Jose V. Lafuente, Dafin F. Muresanu, Zhenrong R. Tian, Ranjana Patnaik and Aruna Sharma
DOI: 10.2174/1871527314666150318114335

Not Just the Brain: Methamphetamine Disrupts Blood-Spinal Cord Barrier and Induces Acute Glial Activation and Structural Damage of Spinal Cord Cells

Volume: 14   Issue: 2
Pp: 282-294
Eugene A. Kiyatkin and Hari S. Sharma
DOI: 10.2174/1871527314666150217121354

TDP-43 as a Modulator of Synaptic Plasticity in a Mouse Model of Spinal Motoneuron Degeneration promotion: free to download

Volume: 14   Issue: 1
Pp: 55-60
Rosario Gulino, Stefano Forte, Rosalba Parenti and Massimo Gulisano
DOI: 10.2174/1871527314666150116115414

Gut Emotions - Mechanisms of Action of Probiotics as Novel Therapeutic Targets for Depression and Anxiety Disorders

Volume: 13   Issue: 10
Pp: 1770-1786
Anastasiya Slyepchenko, Andre F. Carvalho, Danielle S. Cha, Siegfried Kasper and Roger S. McIntyre
DOI: 10.2174/1871527313666141130205242

Modulation of the FGF14:FGF14 Homodimer Interaction Through Short Peptide Fragments

Volume: 13   Issue: 9
Pp: 1559-1570
Syed Ali, Alexander Shavkunov, Neli Panova, Svetla Stoilova-McPhie and Fernanda Laezza
DOI: 10.2174/1871527313666141126103309

Poly (D,L-Lactide-co-Glycolide) Nanoparticles Loaded with Cerebrolysin Display Neuroprotective Activity in a Rat Model of Concussive Head Injury

Volume: 13   Issue: 8
Pp: 1475-1482
Barbara Ruozi, Daniela Belletti, Flavio Forni, Aruna Sharma, Dafin Muresanu, Herbert Mossler, Maria A. Vandelli, Giovanni Tosi and Hari S. Sharma
DOI: 10.2174/1871527313666140806145540

Natural Compounds and Plant Extracts as Therapeutics Against Chronic Inflammation in Alzheimer's Disease - A Translational Perspective

Volume: 13   Issue: 7
Pp: 1175-1191
Nadine Apetz, Gerald Munch, Suresh Govindaraghavan and Erika Gyengesi
DOI: 10.2174/1871527313666140917110635

Effects of Exercise on Anxiety and Depression Disorders: Review of Meta- Analyses and Neurobiological Mechanisms

Volume: 13   Issue: 6
Pp: 1002-1014
Mirko Wegner, Ingo Helmich, Sergio Machado, Antonio E. Nardi, Oscar Arias-Carrion and Henning Budde
DOI: 10.2174/1871527313666140612102841

Targeting of Peripherally Expressed Pain-Related Molecules in Injury- Induced Chronic Neuropathic Pain

Volume: 13   Issue: 5
Pp: 846-873
Takashi Hirai and Aldric Hama
DOI: 10.2174/1871527313666140711092415

Positive Allosteric Modulators (PAMs) of Metabotropic Glutamate Receptor 5 (mGluR5) Attenuate Microglial Activation

Volume: 13   Issue: 4
Pp: 558-566
Fengtian Xue, Bogdan A. Stoica, Marie Hanscom, Shruti V. Kabadi and Alan I. Faden
DOI: 10.2174/18715273113126660199