Abstract
The prolongation of skeletal muscle strength in aging and neuromuscular disease has been the objective of numerous studies employing a variety of approaches. To date however, efforts to prevent or attenuate age- or disease-related muscle degeneration have been largely unsuccessful. Cell-based therapies have been stalled by the difficulty in obtaining sufficient numbers of autologous myoblasts and by inefficient incorporation into host muscle. Administration of growth hormone prevents age-related loss of muscle mass, but has failed to increase muscle strength. In this context, where direct therapeutic approaches to redress the primary disease are still suboptimal, it may be more effective to focus on strategies for improving skeletal muscle function. Experimental models of muscle growth and regeneration have implicated Insulin-like Growth Factor-1 (IGF-1) as an important mediator of anabolic pathways in skeletal muscle cells. Two major IGF-1 transcripts are characterized: the locally acting isoform wi th an autocrine / paracrine action and the circulating isoform with endocrine effects. The physiological differences between the function of local and circulating isoform of IGF-1 are not completely established. However the selective expression of the muscle-specific IGF-1 isoform avoids hypertrophic effects on distal organs such as the heart, and eliminates risk of possible neoplasms induced by inappropriate high expression levels of circulating IGF-1. In this review we discuss the roles of IGF-1 isoforms in myogenesis and the potential therapeutic role of local IGF-1 isoform on muscle aging and diseases.
Keywords: igf-1, igf-1 isoform, igf-1 gene
Current Genomics
Title: The Role of local Insulin-like Growth Factor-1 Isoforms in the Pathophysiology of Skeletal Muscle
Volume: 3 Issue: 3
Author(s): A. Musaro and N. Rosenthal
Affiliation:
Keywords: igf-1, igf-1 isoform, igf-1 gene
Abstract: The prolongation of skeletal muscle strength in aging and neuromuscular disease has been the objective of numerous studies employing a variety of approaches. To date however, efforts to prevent or attenuate age- or disease-related muscle degeneration have been largely unsuccessful. Cell-based therapies have been stalled by the difficulty in obtaining sufficient numbers of autologous myoblasts and by inefficient incorporation into host muscle. Administration of growth hormone prevents age-related loss of muscle mass, but has failed to increase muscle strength. In this context, where direct therapeutic approaches to redress the primary disease are still suboptimal, it may be more effective to focus on strategies for improving skeletal muscle function. Experimental models of muscle growth and regeneration have implicated Insulin-like Growth Factor-1 (IGF-1) as an important mediator of anabolic pathways in skeletal muscle cells. Two major IGF-1 transcripts are characterized: the locally acting isoform wi th an autocrine / paracrine action and the circulating isoform with endocrine effects. The physiological differences between the function of local and circulating isoform of IGF-1 are not completely established. However the selective expression of the muscle-specific IGF-1 isoform avoids hypertrophic effects on distal organs such as the heart, and eliminates risk of possible neoplasms induced by inappropriate high expression levels of circulating IGF-1. In this review we discuss the roles of IGF-1 isoforms in myogenesis and the potential therapeutic role of local IGF-1 isoform on muscle aging and diseases.
Export Options
About this article
Cite this article as:
Musaro A. and Rosenthal N., The Role of local Insulin-like Growth Factor-1 Isoforms in the Pathophysiology of Skeletal Muscle, Current Genomics 2002; 3 (3) . https://dx.doi.org/10.2174/1389202023350462
DOI https://dx.doi.org/10.2174/1389202023350462 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Advanced Computational Algorithms and Artificial Intelligence in Clinical Pharmacogenomics
In the era of personalized medicine, understanding the relationship between genetics and drug response is crucial. This issue delves into innovative methodologies, leveraging deep computational analysis and artificial intelligence, to enhance the field of Clinical Pharmacogenomics. The interdisciplinary approach harnesses the power of advanced high-throughput genotyping technologies, sophisticated computational analysis, ...read more
Applications of Single-cell Sequencing Technology in Reproductive Medicine
Single cell sequencing (SCS) technology utilizes individual cells' genetic material to sequence their genome, transcriptome, and epigenetics at the molecular level. It offers insights into cell heterogeneity and enables the study of limited biological materials. Since its recognition as a valuable technique in 2011, single cell sequencing has yielded numerous ...read more
Big Data in Cancer Research
Cancer is a significant threat to human life and health, remaining a highly aggressive killer. It is a leading cause of death worldwide and represents a crucial medical issue for humanity. However, in the past decade, the effectiveness of new synthetic anticancer agents has not matched the current clinical speculation. ...read more
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Heat Shock Proteins: Therapeutic Drug Targets for Chronic Neurodegeneration?
Current Pharmaceutical Biotechnology Molecular Diagnosis and Treatment of Multiple Endocrine Neoplasia Type 2B in Ethnic Han Chinese
Endocrine, Metabolic & Immune Disorders - Drug Targets Cardioprotective Effects of Indian Gooseberry (Emblica officinalis Gaertn) and its Phytochemicals: A Review
Current Nutrition & Food Science SHP-2 Regulates Growth Factor Dependent Vascular Signalling and Function
Mini-Reviews in Medicinal Chemistry Endothelial Cell Regulation of Cardiac Metabolism Following Diabetes
Cardiovascular & Hematological Disorders-Drug Targets N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP): Potential target molecule in research of heart, kidney and brain
Current Pharmaceutical Design Thymosin β4 Protein Therapy for Cardiac Repair
Current Pharmaceutical Design Cytopathological Mechanisms in Mitochondrial Disease
Current Chemical Biology Deep Inspiration Breath-hold (DIBH) Technique to Reduce Cardiac Radiation Dose in the Management of Breast Cancer
Current Cancer Therapy Reviews Atrial Fibrillation with a Focus on Oral Antiarrhythmic Therapy
Current Drug Therapy New Therapies to Modulate Post-Infarction Inflammatory Alterations in the Myocardium: State of the Art and Forthcoming Applications
Current Radiopharmaceuticals LCHAD and MTP Deficiencies - Two Disorders of Mitochondrial Fatty Acid β-Oxidation with Unusual Features
Current Pediatric Reviews Leptin- and Leptin Receptor-Deficient Rodent Models: Relevance for Human Type 2 Diabetes
Current Diabetes Reviews Quantitative Analysis in Cardiovascular Imaging: Current Status
Current Medical Imaging Targets for Anti-T. cruzi Drugs in the Post-Genomic Era
Current Enzyme Inhibition Calcium Ions in Inherited Cardiomyopathies
Medicinal Chemistry Myocardial Quantitative Analysis in Physiological and Pathological Ventricular Hypertrophy: The Increasing Role of Doppler Myocardial Imaging
Current Cardiology Reviews HLA-G - From Fetal Tolerance to a Regulatory Molecule in Inflammatory Diseases
Current Immunology Reviews (Discontinued) Ventricular Arrhythmias in Seniors with Heart Failure: Present Dilemmas and Therapeutic Considerations: A Systematic Review
Current Cardiology Reviews Mitochondrial genome sequencing in atherosclerosis: what's next?
Current Pharmaceutical Design