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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

N-Substituted Amides as Chiral Ligands for Catalytic Asymmetric Reactions

Author(s): Ji Zhang, Hai-Bing Zhou and Ru-Gang Xie

Volume 6, Issue 10, 2002

Page: [865 - 890] Pages: 26

DOI: 10.2174/1385272023373806

Price: $65

Abstract

In this review we introduced many kinds of bifunctional N-substituted amides, including phosphinamides and phosphoramides, squaramides, sulfonamides and so on which were applied to the asymmetric reactions. More emphasis were given to the asymmetric borane reduction of prochiral ketones, the reaction conditions and mechanisms were discussed systematically. At the same time, other reactions, including asymmetric addition, Diels-Alder reaction and Aldol reactions catalyzed by chiral N-substituted amides were also reviewed.

Keywords: N-Substituted Amides, Chiral Ligands, squaramides


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