Current Alzheimer Research

Debomoy K. Lahiri  
Department of Psychiatry, Indiana University School of Medicine
Neuroscience Research Center
Indianapolis, IN 46202
USA

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Open Access Articles

Biomarkers for Alzheimer's Disease Diagnosis open Access plus

Volume: 14   Issue: 11
Pp: 1149-1154
Vasileios Mantzavinos and Athanasios Alexiou*
DOI:10.2174/1567205014666170203125942

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iTRAQ-based Proteomic Analysis of APPSw,Ind Mice Provides Insights into the Early Changes in Alzheimer’s Disease open Access plus

Volume: 14   Issue: 10
Pp: 1109-1122
Nan Li, Pinghong Hu, Tiantian Xu, Huan Chen, Xiaoying Chen, Jianwen Hu, Xifei Yang, Lei Shi, Jian-hong Luo and Junyu Xu*
DOI:10.2174/1567205014666170719165745

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Association between Periodontal Health Status and Cognitive Abilitie s. The Role of Cytokine Profile and Systemic Inflammation open Access plus

Volume: 14   Issue: 9
Pp: 978-990
Marta Sochocka*, Maciej Sobczyński , Aleksandra Sender-Janeczek , Katarzyna Zwolińska , Olga Błachowicz , Tomasz Tomczyk, Marek Ziętek and Jerzy Leszek
DOI:10.2174/1567205014666170316163340

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Impact of Cytokines and Chemokines on Alzheimer’s Disease Neuropathological Hallmarks open Access plus

Volume: 14   Issue: 8
Pp: 870-882
Catarina Domingues, Odete A.B. da Cruz e Silva and Ana Gabriela Henriques*
DOI:10.2174/1567205014666170317113606

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Abnormal Clock Gene Expression and Locomotor Activity Rhythms in Two Month-Old Female APPSwe/PS1dE9 Mice open Access plus

Volume: 14   Issue: 8
Pp: 850-860
Olaide Oyegbami, Hilary M. Collins, Marie-Christine Pardon, Francis J.P. Ebling, David M. Heery and Paula M. Moran*
DOI:10.2174/1567205014666170317113159

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Long-Term Extensions of Randomized Vaccination Trials of ACC-001 and QS-21 in Mild to Moderate Alzheimer’s Disease open Access plus

Volume: 14   Issue: 7
Pp: 696-708
Michael Hull*, Carl Sadowsky, Heii Arai, Ghislaine Le Prince Leterme, Ann Holstein, Kevin Booth, Yahong Peng, Tamotsu Yoshiyama, Hideo Suzuki, Nzeera Ketter, Enchi Liu and J. Michael Ryan
DOI:10.2174/1567205014666170117101537

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Marginal Vitamin A Deficiency Exacerbates Memory Deficits Following Aβ1-42 Injection in Rats open Access plus

Volume: 14   Issue: 5
Pp: 562-570
Jiaying Zeng, Tingyu Li, Ming Gong, Wei Jiang, Ting Yang, Jie Chen, Youxue Liu and Li Chen
DOI:10.2174/1567205013666161223162110

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Comparison of Extracellular and Intracellular Blood Compartments Highlights Redox Alterations in Alzheimer's and Mild Cognitive Impairment Patients open Access plus

Volume: 14   Issue: 1
Pp: 112-122
Noemí Arce-Varas, Giulia Abate, Chiara Prandelli, Carmen Martínez, Fernando Cuetos, Manuel Menéndez, Mariagrazia Marziano, David Cabrera-García, María Teresa Fernández-Sánchez, Antonello Novelli, Maurizio Memo and Daniela Uberti
DOI:10.2174/1567205013666161010125413

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Evaluation of Metabolic and Synaptic Dysfunction Hypotheses of Alzheimer’s Disease (AD): A Meta-Analysis of CSF Markers open Access plus

Volume: 14   Issue:
Pp: 1-18
Roni Manyevitch, Matthew Protas, Sean Scarpiello, Marisa Deliso, Brittany Bass, Anthony Nanajian, Matthew Chang, Stefani M. Thompson, Neil Khoury, Rachel Gonnella, Margit Trotz, D. Blaine Moore, Emily Harms, George Perry, Lucy Clunes, Angélica Ortiz, Jan O. Friedrich and Ian V.J. Murray*
DOI:10.2174/1567205014666170921122458

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Genetically-mediated Grey and White Matter Alteration in Normal Elderly Individuals with the CLU-C Allele Gene open Access plus

Volume: 13   Issue: 11
Pp: 1302-1310
Lihua Qiu, Yong He, Hehan Tang, Yi Zhou, Jinhong Wang, Weiwei Zhang, Guangxiang Chen, Fei Zhao, Tingxue Ouyang, Bin Ju, Zhengyan Li, Lanlan Wang, Ling Zou and Qiyong Gong
DOI:10.2174/1567205013666160703180531

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Neuropsychiatric Disturbances in Alzheimer’s Disease: What Have We Learned from Neuropathological Studies? open Access plus

Volume: 13   Issue: 10
Pp: 1145-1164
Debby Van Dam, Yannick Vermeiren, Alain D. Dekker, Petrus J.W. Naudé and Peter P. De Deyn
DOI:10.2174/1567205013666160502123607

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The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer’s Disease open Access plus

Volume: 13   Issue: 9
Pp: 985-995
Marco Magistri, Dmitry Velmeshev, Madina Makhmutova, Prutha Patel, Gregory C. Sartor, Claude-Henry Volmar, Claes Wahlestedt and Mohammad Ali Faghihi
DOI:10.2174/1567205013666160427101832

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Decreased Myelinated Fibers in the Hippocampal Dentate Gyrus of the Tg2576 Mouse Model of Alzheimer’s Disease open Access plus

Volume: 13   Issue: 9
Pp: 1040-1047
Wei Lu, Shu Yang, Lei Zhang, Lin Chen, Feng-Lei Chao, Yan-min Luo, Qian Xiao, Heng-Wei Gu, Rong Jiang and Yong Tang
DOI:10.2174/1567205013666160314150709

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Misoprostol Reverse Hippocampal Neuron Cyclooxygenase-2 Downstream Signaling Imbalance in Aluminum-Overload Rats open Access plus

Volume: 13   Issue: 9
Pp: 1006-1016
Yuanxin Guo, Wenjuan Lei, Jianfeng Wang, Xinyue Hu, Yuling Wei, Chaonan Ji and Junqing Yang
DOI:10.2174/1567205013666160401114601

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Probabilistic Cost-Effectiveness Analysis of Vaccination for Mild or Moderate Alzheimer’s Disease open Access plus

Volume: 13   Issue: 7
Pp: 809-816
Kuen-Cheh Yang and Hsiu-Hsi Chen
DOI:10.2174/1567205013666160129095012

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Oral Triphenylmethane Food Dye Analog, Brilliant Blue G, Prevents Neuronal Loss in APPSwDI/NOS2-/- Mouse Model open Access plus

Volume: 13   Issue: 6
Pp: 663-677
Jacob A. Irwin, Alev Erisir and Inchan Kwon
DOI:10.2174/1567205013666160208142456

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Perspectives on the Tertiary Prevention Strategy for Alzheimer’s Disease open Access plus

Volume: 13   Issue: 3
Pp: 307-316
Xian-Le Bu, Shu-Sheng Jiao, Yan Lian and Yan-Jiang Wang
DOI:10.2174/1567205013666151215110114

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Defining the earliest pathological changes of Alzheimer’s disease open Access plus

Volume: 13   Issue: 3
Pp: 281-287
James C. Vickers, Stan Mitew, Adele Woodhouse, Carmen M. Fernandez-Martos, Mathew T. Kirkcaldie, Alison J. Canty, Graeme H. McCormack and Anna E. King
DOI:10.2174/1567205013666151218150322

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Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies open Access plus

Volume: 12   Issue: 9
Pp: 814-828
Marcus Pickhardt, Thomas Neumann, Daniel Schwizer, Kari Callaway, Michele Vendruscolo, Dale Schenk, Peter St. George-Hyslop, Eva M. Mandelkow, Christopher M. Dobson, Lisa McConlogue, Eckhard Mandelkow and Gergely Toth
DOI:10.2174/156720501209151019104951

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Increased Acetylation of Histone H4 at Lysine 12 (H4K12) in Monocytes of Transgenic Alzheimer’s Mice and in Human Patients open Access plus

Volume: 12   Issue: 8
Pp: 752-760
Barbara Plagg, Daniela Ehrlich, Kathrin M. Kniewallner, Josef Marksteiner and Christian Humpel
DOI:10.2174/1567205012666150710114256

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Neurobiology of Alzheimer’s Disease: Integrated Molecular, Physiological, Anatomical, Biomarker, and Cognitive Dimensions open Access plus

Volume: 12   Issue: 8
Pp: 712-722
Joel Raskin, Jeffrey Cummings, John Hardy, Kory Schuh and Robert A. Dean
DOI:10.2174/1567205012666150701103107

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Social Markers of Mild Cognitive Impairment: Proportion of Word Counts in Free Conversational Speech open Access plus

Volume: 12   Issue: 6
Pp: 513-519
Hiroko H. Dodge, Nora Mattek, Mattie Gregor, Molly Bowman, Adriana Seelye, Oscar Ybarra, Meysam Asgari and Jeffrey A. Kaye
DOI:10.2174/1567205012666150530201917

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1950 MHz Electromagnetic Fields Ameliorate Aβ Pathology in Alzheimer’s Disease Mice open Access plus

Volume: 12   Issue: 5
Pp: 481-492
Ye Ji Jeong, Ga-Young Kang, Jong Hwa Kwon, Hyung-Do Choi, Jeong-Ki Pack, Nam Kim, Yun-Sil Lee and Hae-June Lee
DOI:10.2174/156720501205150526114448

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Oxidant/Antioxidant Imbalance and the Risk of Alzheimer's Disease open Access plus

Volume: 12   Issue: 4
Pp: 335-349
Ahmed E. Abdel Moneim
DOI:10.2174/1567205012666150325182702

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Genetic Markers in Biological Fluids for Aging-Related Major Neurocognitive Disorder open Access plus

Volume: 12   Issue: 3
Pp: 200-209
S.A. Castro-Chavira, T. Fernández, H. Nicolini, S. Diaz-Cintra and R.A. Prado-Alcalá
DOI:10.2174/1567205012666150302155138

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Role of Environmental Contaminants in the Etiology of Alzheimer’s Disease: A Review open Access plus

Volume: 12   Issue: 2
Pp: 116-146
Manivannan Yegambaram, Bhagyashree Manivannan, Thomas G. Beach and Rolf U. Halden
DOI:10.2174/1567205012666150204121719

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Age-Dependent Biochemical Dysfunction in Skeletal Muscle of Triple- Transgenic Mouse Model of Alzheimer`s Disease open Access plus

Volume: 12   Issue: 2
Pp: 100-115
Vera F. Monteiro-Cardoso, Marisa Castro, M.M. Oliveira, Paula I. Moreira, Francisco Peixoto and Romeu A. Videira
DOI:10.2174/1567205012666150204124852

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Caspase-3 Short Hairpin RNAs: A Potential Therapeutic Agent in Neurodegeneration of Aluminum-Exposed Animal Model open Access plus

Volume: 11   Issue: 10
Pp: 961-970
Qinli Zhang, Na Li, Xia Jiao, Xiujun Qin, Ramanjit Kaur, Xiaoting Lu, Jing Song, Linping Wang, Junming Wang and Qiao Niu
DOI:10.2174/1567205011666141107150938

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Association of Smoking and Alcohol Drinking with Dementia Risk Among Elderly Men in China open Access plus

Volume: 11   Issue: 9
Pp: 899-907
Shiming Zhou, Rui Zhou, Tingting Zhong, Rui Li, Jun Tan and Huadong Zhou
DOI:10.2174/1567205011666141001123356

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Severe Psychiatric Disorders in Mid-Life and Risk of Dementia in Late- Life (Age 65-84 Years): A Population Based Case-Control Study open Access plus

Volume: 11   Issue: 7
Pp: 681-693
Renate R. Zilkens, David G. Bruce, Janine Duke, Katrina Spilsbury and James B. Semmens
DOI:10.2174/1567205011666140812115004

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An Evaluation of MSDC-0160, A Prototype mTOT Modulating Insulin Sensitizer, in Patients with Mild Alzheimer's Disease open Access plus

Volume: 11   Issue: 6
Pp: 564-573
Raj C. Shah, Dawn C. Matthews, Randolph D. Andrews, Ana W. Capuano, Debra A. Fleischman, James T. VanderLugt and Jerry R. Colca
DOI:10.2174/1567205011666140616113406

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Does an Interdisciplinary Network Improve Dementia Care? Results from the IDemUck-Study open Access plus

Volume: 11   Issue: 6
Pp: 538-548
Leonore Kohler, Claudia Meinke-Franze, Jurgen Hein, Konstanze Fendrich, Romy Heymann, Jochen Rene Thyrian and Wolfgang Hoffmann
DOI:10.2174/1567205011666140618100727

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Biomarkers of Alzheimer's Disease Risk in Peripheral Tissues; Focus on Buccal Cells open Access plus

Volume: 11   Issue: 6
Pp: 519-531
Maxime Francois, Wayne Leifert, Ralph Martins, Philip Thomas and Michael Fenech
DOI:10.2174/1567205011666140618103827

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Early Detection of Cerebral Glucose Uptake Changes in the 5XFAD Mouse open Access plus

Volume: 11   Issue: 5
Pp: 450-460
I.R. Macdonald, D.R. DeBay, G.A. Reid, T.P. O’Leary, C.T. Jollymore, G. Mawko, S. Burrell, E. Martin, C.V. Bowen, R.E. Brown and S. Darvesh
DOI:10.2174/1567205011666140505111354

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Advances in High-Field Magnetic Resonance Spectroscopy in Alzheimer’s Disease open Access plus

Volume: 11   Issue: 4
Pp: 367-388
Ningnannan Zhang, Xiaowei Song, Robert Bartha, Steven Beyea, Ryan D’Arcy, Yunting Zhang and Kenneth Rockwood
DOI:10.2174/1567205011666140302200312

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Understanding the Complexities of Functional Ability in Alzheimer’s Disease: More Than Just Basic and Instrumental Factors open Access plus

Volume: 11   Issue: 4
Pp: 357-366
Kristin Kahle-Wrobleski, Nicola Coley, Benoit Lepage, Christelle Cantet, Bruno Vellas, Sandrine Andrieu and PLASA/DSA Group
DOI:10.2174/1567205011666140317101419

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The prediction of response to Galantamine treatment in Patients with mild to moderate Alzheimer’s Disease open Access plus

Volume: 11   Issue: 2
Pp: 110-118
Takashi Ohnishi, Yojiro Sakiyama, Yuichi Okuri, Yuji Kimura, Nami Sugiyama, Takayuki Saito, Masayoshi Takahashi and Takumi Kobayashi
DOI:10.2174/15672050113106660167

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Optimized Turmeric Extract Reduces β-Amyloid and Phosphorylated Tau Protein Burden in Alzheimer’s Transgenic Mice open Access plus

Volume: 9   Issue: 4
Pp: 500-506
R. Douglas Shytle, Jun Tan, Paula C. Bickford, Kavon Rezai-zadeh, L Hou, Jin Zeng, Paul R. Sanberg, Cyndy D. Sanberg, Randall S. Alberte, Ryan C. Fink and Bill Roschek Jr
DOI:10.2174/156720512800492459

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Effects of Galantamine in Alzheimers Disease: Double-blind Withdrawal Studies Evaluating Sustained Versus Interrupted Treatment open Access plus

Volume: 8   Issue: 7
Pp: 771-780
M. Gaudig, U. Richarz, J. Han, B. Van Baelen and B. Schauble
DOI:10.2174/156720511797633205

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Frontotemporal Dementia Caused by CHMP2B Mutations open Access plus

Volume: 8   Issue: 3
Pp: 246-251
A. M. Isaacs, P. Johannsen, I. Holm, J. E. Nielsen and FReJA Consortium
DOI:10.2174/156720511795563764

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Long-Term Response to Galantamine in Relation to Short-Term Efficacy Data: Pooled Analysis in Patients with Mild to Moderate Alzheimers Disease open Access plus

Volume: 8   Issue: 2
Pp: 175-186
S. Kavanagh, I. Howe, H. R. Brashear, D. Wang, B. Van Baelen, M. Todd and S. Schwalen
DOI:10.2174/156720511795256044

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Baseline MRI Predictors of Conversion from MCI to Probable AD in the ADNI Cohort open Access plus

Volume: 6   Issue: 4
Pp: 347-361
Shannon L. Risacher, Andrew J. Saykin, John D. Wes, Li Shen, Hiram A. Firpi and Brenna C. McDonald
DOI:10.2174/156720509788929273

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Towards Retinoid Therapy for Alzheimers Disease open Access plus

Volume: 6   Issue: 3
Pp: 302-311
K. Shudo, H. Fukasawa, M. Nakagomi and N. Yamagata
DOI:10.2174/156720509788486581

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Natural Non-Trasgenic Animal Models for Research in Alzheimers Disease open Access plus

Volume: 6   Issue: 2
Pp: 171-178
Manuel Sarasa and Pedro Pesini
DOI:10.2174/156720509787602834

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Long-Term Follow-Up of Patients Immunized with AN1792: Reduced Functional Decline in Antibody Responders open Access plus

Volume: 6   Issue: 2
Pp: 144-151
Bruno Vellas, R. Black, Leon J. Thal, Nick C. Fox, M. Daniels, G. McLennan, C. Tompkins, C. Leibman, M. Pomfret and Michael Grundman
DOI:10.2174/156720509787602852

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Assembly of the Asparagine- and Glutamine-Rich Yeast Prions into Protein Fibrils open Access plus

Volume: 5   Issue: 3
Pp: 251-259
Luc Bousset, Jimmy Savistchenko and Ronald Melki
DOI:10.2174/156720508784533303

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A New Glucocorticoid Hypothesis of Brain Aging: Implications for Alzheimers Disease open Access plus

Volume: 4   Issue: 2
Pp: 205-212
Philip W. Landfield, Eric M. Blalock, Kuey-Chu Chen and Nada M. Porter
DOI:10.2174/156720507780362083

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De Novo and Molecular Target-Independent Discovery of Orally Bioavailable Lead Compounds for Neurological Disorders open Access plus

Volume: 3   Issue: 3
Pp: 205-214
Laura K. Wing, Heather A. Behanna, Linda J. Van Eldik, D. Martin Watterson and Hantamalala Ralay Ranaivo
DOI:10.2174/156720506777632844

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Induction of RhoGAP and Pathological Changes Characteristic of Alzheimers Disease by UAHFEMF Discharge in Rat Brain open Access plus

Volume: 2   Issue: 5
Pp: 559-569
Ing-Feng Chang and Huo-Yen Hsiao
DOI:10.2174/156720505774932269

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