Current Alzheimer Research

Impact of a Clinical Decision Support Tool on Dementia Diagnostics in Memory Clinics: The PredictND Validation Study open Access plus

Volume: 16   Issue: 2
Pp: 91-101
Marie Bruun*, Kristian S. Frederiksen, Hanneke F.M. Rhodius-Meester, Marta Baroni, Le Gjerum, Juha Koikkalainen, Timo Urhemaa, Antti Tolonen, Mark van Gils, Tong Tong, Ricardo Guerrero, Daniel Rueckert, Nadia Dyremose, Birgitte Bo Andersen, Anja H. Simonsen, Afina Lemstra, Merja Hallikainen, Sudhir Kurl, Sanna-Kaisa Herukka, Anne M. Remes, Gunhild Waldemar, Hilkka Soininen, Patrizia Mecocci, Wiesje M. van der Flier, Jyrki Lötjönen and Steen G. Hasselbalch
DOI:10.2174/1567205016666190103152425

Anti-α4β1 Integrin Antibodies Attenuated Brain Inflammatory Changes in a Mouse Model of Alzheimer’s Disease open Access plus

Volume: 15   Issue: 12
Pp: 1123-1135
Gunjan Manocha, Atreyi Ghatak, Kendra Puig and Colin Combs*
DOI:10.2174/1567205015666180801111033

Probiotic Supplementation in Patients with Alzheimer’s Dementia - An Explorative Intervention Study open Access plus

Volume: 15   Issue: 12
Pp: 1106-1113
Friedrich Leblhuber, Kostja Steiner, Burkhard Schuetz, Dietmar Fuchs* and Johanna M. Gostner
DOI:10.2174/1389200219666180813144834

Technological Solutions for Older People with Alzheimer’s Disease: Review open Access plus

Volume: 15   Issue: 10
Pp: 975-983
Petra Maresova*, Signe Tomsone, Petre Lameski, Joana Madureira, Ana Mendes, Eftim Zdravevski, Ivan Chorbev, Vladimir Trajkovik, Moriah Ellen and Kasper Rodile
DOI:10.2174/1567205015666180427124547

Strategies for Continued Successful Treatment in Patients with Alzheimer’s Disease: An Overview of Switching Between Pharmacological Agents open Access plus

Volume: 15   Issue: 10
Pp: 964-974
Rafael Blesa, Kazuhiro Toriyama*, Kengo Ueda, Sean Knox and George Grossberg
DOI:10.2174/1567205015666180613112040

Interplay between the APOE Genotype and Possible Plasma Biomarkers in Alzheimer’s Disease open Access plus

Volume: 15   Issue: 10
Pp: 938-950
Martina Zverova, Eva Kitzlerova, Zdenek Fisar*, Roman Jirak, Jana Hroudova, Hana Benakova, Petra Lelkova, Pavel Martasek and Jiri Raboch
DOI:10.2174/1567205015666180601090533

Short-Term Response to Cholinesterase Inhibitors in Alzheimer’s Disease Delays Time to Nursing Home Placement open Access plus

Volume: 15   Issue: 10
Pp: 905-916
Carina Wattmo*, Elisabet Londos and Lennart Minthon
DOI:10.2174/1567205015666180507105326

Up-regulation of DMN Connectivity in Mild Cognitive Impairment Via Network-based Cognitive Training open Access plus

Volume: 15   Issue: 6
Pp: 578-589
Matteo De Marco, Francesca Meneghello, Cristina Pilosio, Jessica Rigon and Annalena Venneri*
DOI:10.2174/1567205015666171212103323

An Inflammation-related Nutrient Pattern is Associated with Both Brain and Cognitive Measures in a Multiethnic Elderly Population open Access plus

Volume: 15   Issue: 5
Pp: 493-501
Yian Gu*, Jennifer J. Manly, Richard P. Mayeux and Adam M. Brickman
DOI:10.2174/1567205015666180101145619

Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment open Access plus

Volume: 15   Issue: 5
Pp: 482-492
Kiyomi Nishimaki, Takashi Asada*, Ikuroh Ohsawa, Etsuko Nakajima, Chiaki Ikejima, Takashi Yokota, Naomi Kamimura and Shigeo Ohta*
DOI:10.2174/1567205014666171106145017

Evaluation of Metabolic and Synaptic Dysfunction Hypotheses of Alzheimer's Disease (AD): A Meta-Analysis of CSF Markers open Access plus

Volume: 15   Issue: 2
Pp: 164-181
Roni Manyevitch, Matthew Protas, Sean Scarpiello, Marisa Deliso, Brittany Bass, Anthony Nanajian, Matthew Chang, Stefani M. Thompson, Neil Khoury, Rachel Gonnella, Margit Trotz, D. Blaine Moore, Emily Harms, George Perry, Lucy Clunes, Angelica Ortiz, Jan O. Friedrich and Ian V.J. Murray*
DOI:10.2174/1567205014666170921122458

A Speech Recognition-based Solution for the Automatic Detection of Mild Cognitive Impairment from Spontaneous Speech open Access plus

Volume: 15   Issue: 2
Pp: 130-138
Laszlo Toth*, Ildiko Hoffmann, Gabor Gosztolya, Veronika Vincze, Greta Szatloczki, Zoltan Banreti, Magdolna Pakaski and Janos Kalman
DOI:10.2174/1567205014666171121114930

Biomarkers for Alzheimer's Disease Diagnosis open Access plus

Volume: 14   Issue: 11
Pp: 1149-1154
Vasileios Mantzavinos and Athanasios Alexiou*
DOI:10.2174/1567205014666170203125942

iTRAQ-based Proteomic Analysis of APPSw,Ind Mice Provides Insights into the Early Changes in Alzheimer’s Disease open Access plus

Volume: 14   Issue: 10
Pp: 1109-1122
Nan Li, Pinghong Hu, Tiantian Xu, Huan Chen, Xiaoying Chen, Jianwen Hu, Xifei Yang, Lei Shi, Jian-hong Luo and Junyu Xu*
DOI:10.2174/1567205014666170719165745

Association between Periodontal Health Status and Cognitive Abilitie s. The Role of Cytokine Profile and Systemic Inflammation open Access plus

Volume: 14   Issue: 9
Pp: 978-990
Marta Sochocka*, Maciej Sobczyński , Aleksandra Sender-Janeczek , Katarzyna Zwolińska , Olga Błachowicz , Tomasz Tomczyk, Marek Ziętek and Jerzy Leszek
DOI:10.2174/1567205014666170316163340

Kinematic and Pressure Features of Handwriting and Drawing: Preliminary Results Between Patients with Mild Cognitive Impairment, Alzheimer Disease and Healthy Controls open Access plus

Volume: 14   Issue: 9
Pp: 960-968
Josep Garre-Olmo, Marcos Faúndez-Zanuy, Karmele López-de-Ipiña*, Laia Calvó-Perxas and Oriol Turró-Garriga
DOI:10.2174/1567205014666170309120708

Impact of Cytokines and Chemokines on Alzheimer’s Disease Neuropathological Hallmarks open Access plus

Volume: 14   Issue: 8
Pp: 870-882
Catarina Domingues, Odete A.B. da Cruz e Silva and Ana Gabriela Henriques*
DOI:10.2174/1567205014666170317113606

Abnormal Clock Gene Expression and Locomotor Activity Rhythms in Two Month-Old Female APPSwe/PS1dE9 Mice open Access plus

Volume: 14   Issue: 8
Pp: 850-860
Olaide Oyegbami, Hilary M. Collins, Marie-Christine Pardon, Francis J.P. Ebling, David M. Heery and Paula M. Moran*
DOI:10.2174/1567205014666170317113159

Long-Term Extensions of Randomized Vaccination Trials of ACC-001 and QS-21 in Mild to Moderate Alzheimer’s Disease open Access plus

Volume: 14   Issue: 7
Pp: 696-708
Michael Hull*, Carl Sadowsky, Heii Arai, Ghislaine Le Prince Leterme, Ann Holstein, Kevin Booth, Yahong Peng, Tamotsu Yoshiyama, Hideo Suzuki, Nzeera Ketter, Enchi Liu and J. Michael Ryan
DOI:10.2174/1567205014666170117101537

Marginal Vitamin A Deficiency Exacerbates Memory Deficits Following Aβ1-42 Injection in Rats open Access plus

Volume: 14   Issue: 5
Pp: 562-570
Jiaying Zeng, Tingyu Li, Ming Gong, Wei Jiang, Ting Yang, Jie Chen, Youxue Liu and Li Chen
DOI:10.2174/1567205013666161223162110

Comparison of Extracellular and Intracellular Blood Compartments Highlights Redox Alterations in Alzheimer's and Mild Cognitive Impairment Patients open Access plus

Volume: 14   Issue: 1
Pp: 112-122
Noemí Arce-Varas, Giulia Abate, Chiara Prandelli, Carmen Martínez, Fernando Cuetos, Manuel Menéndez, Mariagrazia Marziano, David Cabrera-García, María Teresa Fernández-Sánchez, Antonello Novelli, Maurizio Memo and Daniela Uberti
DOI:10.2174/1567205013666161010125413

Genetically-mediated Grey and White Matter Alteration in Normal Elderly Individuals with the CLU-C Allele Gene open Access plus

Volume: 13   Issue: 11
Pp: 1302-1310
Lihua Qiu, Yong He, Hehan Tang, Yi Zhou, Jinhong Wang, Weiwei Zhang, Guangxiang Chen, Fei Zhao, Tingxue Ouyang, Bin Ju, Zhengyan Li, Lanlan Wang, Ling Zou and Qiyong Gong
DOI:10.2174/1567205013666160703180531

Neuropsychiatric Disturbances in Alzheimer’s Disease: What Have We Learned from Neuropathological Studies? open Access plus

Volume: 13   Issue: 10
Pp: 1145-1164
Debby Van Dam, Yannick Vermeiren, Alain D. Dekker, Petrus J.W. Naudé and Peter P. De Deyn
DOI:10.2174/1567205013666160502123607

The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer’s Disease open Access plus

Volume: 13   Issue: 9
Pp: 985-995
Marco Magistri, Dmitry Velmeshev, Madina Makhmutova, Prutha Patel, Gregory C. Sartor, Claude-Henry Volmar, Claes Wahlestedt and Mohammad Ali Faghihi
DOI:10.2174/1567205013666160427101832

Decreased Myelinated Fibers in the Hippocampal Dentate Gyrus of the Tg2576 Mouse Model of Alzheimer’s Disease open Access plus

Volume: 13   Issue: 9
Pp: 1040-1047
Wei Lu, Shu Yang, Lei Zhang, Lin Chen, Feng-Lei Chao, Yan-min Luo, Qian Xiao, Heng-Wei Gu, Rong Jiang and Yong Tang
DOI:10.2174/1567205013666160314150709

Misoprostol Reverse Hippocampal Neuron Cyclooxygenase-2 Downstream Signaling Imbalance in Aluminum-Overload Rats open Access plus

Volume: 13   Issue: 9
Pp: 1006-1016
Yuanxin Guo, Wenjuan Lei, Jianfeng Wang, Xinyue Hu, Yuling Wei, Chaonan Ji and Junqing Yang*
DOI:10.2174/1567205013666160401114601

Probabilistic Cost-Effectiveness Analysis of Vaccination for Mild or Moderate Alzheimer’s Disease open Access plus

Volume: 13   Issue: 7
Pp: 809-816
Kuen-Cheh Yang and Hsiu-Hsi Chen
DOI:10.2174/1567205013666160129095012

Oral Triphenylmethane Food Dye Analog, Brilliant Blue G, Prevents Neuronal Loss in APPSwDI/NOS2-/- Mouse Model open Access plus

Volume: 13   Issue: 6
Pp: 663-677
Jacob A. Irwin, Alev Erisir and Inchan Kwon
DOI:10.2174/1567205013666160208142456

Perspectives on the Tertiary Prevention Strategy for Alzheimer’s Disease open Access plus

Volume: 13   Issue: 3
Pp: 307-316
Xian-Le Bu, Shu-Sheng Jiao, Yan Lian and Yan-Jiang Wang
DOI:10.2174/1567205013666151215110114

Defining the earliest pathological changes of Alzheimer’s disease open Access plus

Volume: 13   Issue: 3
Pp: 281-287
James C. Vickers, Stan Mitew, Adele Woodhouse, Carmen M. Fernandez-Martos, Mathew T. Kirkcaldie, Alison J. Canty, Graeme H. McCormack and Anna E. King
DOI:10.2174/1567205013666151218150322

Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies open Access plus

Volume: 12   Issue: 9
Pp: 814-828
Marcus Pickhardt, Thomas Neumann, Daniel Schwizer, Kari Callaway, Michele Vendruscolo, Dale Schenk, Peter St. George-Hyslop, Eva M. Mandelkow, Christopher M. Dobson, Lisa McConlogue, Eckhard Mandelkow and Gergely Toth
DOI:10.2174/156720501209151019104951

Increased Acetylation of Histone H4 at Lysine 12 (H4K12) in Monocytes of Transgenic Alzheimer’s Mice and in Human Patients open Access plus

Volume: 12   Issue: 8
Pp: 752-760
Barbara Plagg, Daniela Ehrlich, Kathrin M. Kniewallner, Josef Marksteiner and Christian Humpel
DOI:10.2174/1567205012666150710114256

Neurobiology of Alzheimer’s Disease: Integrated Molecular, Physiological, Anatomical, Biomarker, and Cognitive Dimensions open Access plus

Volume: 12   Issue: 8
Pp: 712-722
Joel Raskin, Jeffrey Cummings, John Hardy, Kory Schuh and Robert A. Dean
DOI:10.2174/1567205012666150701103107

Social Markers of Mild Cognitive Impairment: Proportion of Word Counts in Free Conversational Speech open Access plus

Volume: 12   Issue: 6
Pp: 513-519
Hiroko H. Dodge, Nora Mattek, Mattie Gregor, Molly Bowman, Adriana Seelye, Oscar Ybarra, Meysam Asgari and Jeffrey A. Kaye
DOI:10.2174/1567205012666150530201917

1950 MHz Electromagnetic Fields Ameliorate Aβ Pathology in Alzheimer’s Disease Mice open Access plus

Volume: 12   Issue: 5
Pp: 481-492
Ye Ji Jeong, Ga-Young Kang, Jong Hwa Kwon, Hyung-Do Choi, Jeong-Ki Pack, Nam Kim, Yun-Sil Lee and Hae-June Lee
DOI:10.2174/156720501205150526114448

Oxidant/Antioxidant Imbalance and the Risk of Alzheimer's Disease open Access plus

Volume: 12   Issue: 4
Pp: 335-349
Ahmed E. Abdel Moneim
DOI:10.2174/1567205012666150325182702

Genetic Markers in Biological Fluids for Aging-Related Major Neurocognitive Disorder open Access plus

Volume: 12   Issue: 3
Pp: 200-209
S.A. Castro-Chavira, T. Fernández, H. Nicolini, S. Diaz-Cintra and R.A. Prado-Alcalá
DOI:10.2174/1567205012666150302155138

Role of Environmental Contaminants in the Etiology of Alzheimer’s Disease: A Review open Access plus

Volume: 12   Issue: 2
Pp: 116-146
Manivannan Yegambaram, Bhagyashree Manivannan, Thomas G. Beach and Rolf U. Halden
DOI:10.2174/1567205012666150204121719

Age-Dependent Biochemical Dysfunction in Skeletal Muscle of Triple- Transgenic Mouse Model of Alzheimer`s Disease open Access plus

Volume: 12   Issue: 2
Pp: 100-115
Vera F. Monteiro-Cardoso, Marisa Castro, M.M. Oliveira, Paula I. Moreira, Francisco Peixoto and Romeu A. Videira
DOI:10.2174/1567205012666150204124852

Caspase-3 Short Hairpin RNAs: A Potential Therapeutic Agent in Neurodegeneration of Aluminum-Exposed Animal Model open Access plus

Volume: 11   Issue: 10
Pp: 961-970
Qinli Zhang, Na Li, Xia Jiao, Xiujun Qin, Ramanjit Kaur, Xiaoting Lu, Jing Song, Linping Wang, Junming Wang and Qiao Niu
DOI:10.2174/1567205011666141107150938

Association of Smoking and Alcohol Drinking with Dementia Risk Among Elderly Men in China open Access plus

Volume: 11   Issue: 9
Pp: 899-907
Shiming Zhou, Rui Zhou, Tingting Zhong, Rui Li, Jun Tan and Huadong Zhou
DOI:10.2174/1567205011666141001123356

Severe Psychiatric Disorders in Mid-Life and Risk of Dementia in Late- Life (Age 65-84 Years): A Population Based Case-Control Study open Access plus

Volume: 11   Issue: 7
Pp: 681-693
Renate R. Zilkens, David G. Bruce, Janine Duke, Katrina Spilsbury and James B. Semmens
DOI:10.2174/1567205011666140812115004

An Evaluation of MSDC-0160, A Prototype mTOT Modulating Insulin Sensitizer, in Patients with Mild Alzheimer's Disease open Access plus

Volume: 11   Issue: 6
Pp: 564-573
Raj C. Shah, Dawn C. Matthews, Randolph D. Andrews, Ana W. Capuano, Debra A. Fleischman, James T. VanderLugt and Jerry R. Colca
DOI:10.2174/1567205011666140616113406

Does an Interdisciplinary Network Improve Dementia Care? Results from the IDemUck-Study open Access plus

Volume: 11   Issue: 6
Pp: 538-548
Leonore Kohler, Claudia Meinke-Franze, Jurgen Hein, Konstanze Fendrich, Romy Heymann, Jochen Rene Thyrian and Wolfgang Hoffmann
DOI:10.2174/1567205011666140618100727

Biomarkers of Alzheimer's Disease Risk in Peripheral Tissues; Focus on Buccal Cells open Access plus

Volume: 11   Issue: 6
Pp: 519-531
Maxime Francois, Wayne Leifert, Ralph Martins, Philip Thomas and Michael Fenech
DOI:10.2174/1567205011666140618103827

Early Detection of Cerebral Glucose Uptake Changes in the 5XFAD Mouse open Access plus

Volume: 11   Issue: 5
Pp: 450-460
I.R. Macdonald, D.R. DeBay, G.A. Reid, T.P. O’Leary, C.T. Jollymore, G. Mawko, S. Burrell, E. Martin, C.V. Bowen, R.E. Brown and S. Darvesh
DOI:10.2174/1567205011666140505111354

Advances in High-Field Magnetic Resonance Spectroscopy in Alzheimer’s Disease open Access plus

Volume: 11   Issue: 4
Pp: 367-388
Ningnannan Zhang, Xiaowei Song, Robert Bartha, Steven Beyea, Ryan D’Arcy, Yunting Zhang and Kenneth Rockwood
DOI:10.2174/1567205011666140302200312

Understanding the Complexities of Functional Ability in Alzheimer’s Disease: More Than Just Basic and Instrumental Factors open Access plus

Volume: 11   Issue: 4
Pp: 357-366
Kristin Kahle-Wrobleski, Nicola Coley, Benoit Lepage, Christelle Cantet, Bruno Vellas, Sandrine Andrieu and PLASA/DSA Group
DOI:10.2174/1567205011666140317101419

The prediction of response to Galantamine treatment in Patients with mild to moderate Alzheimer’s Disease open Access plus

Volume: 11   Issue: 2
Pp: 110-118
Takashi Ohnishi, Yojiro Sakiyama, Yuichi Okuri, Yuji Kimura, Nami Sugiyama, Takayuki Saito, Masayoshi Takahashi and Takumi Kobayashi
DOI:10.2174/15672050113106660167

Optimized Turmeric Extract Reduces β-Amyloid and Phosphorylated Tau Protein Burden in Alzheimer’s Transgenic Mice open Access plus

Volume: 9   Issue: 4
Pp: 500-506
R. Douglas Shytle, Jun Tan, Paula C. Bickford, Kavon Rezai-zadeh, L Hou, Jin Zeng, Paul R. Sanberg, Cyndy D. Sanberg, Randall S. Alberte, Ryan C. Fink and Bill Roschek Jr
DOI:10.2174/156720512800492459

Effects of Galantamine in Alzheimers Disease: Double-blind Withdrawal Studies Evaluating Sustained Versus Interrupted Treatment open Access plus

Volume: 8   Issue: 7
Pp: 771-780
M. Gaudig, U. Richarz, J. Han, B. Van Baelen and B. Schauble
DOI:10.2174/156720511797633205

Frontotemporal Dementia Caused by CHMP2B Mutations open Access plus

Volume: 8   Issue: 3
Pp: 246-251
A. M. Isaacs, P. Johannsen, I. Holm, J. E. Nielsen and FReJA Consortium
DOI:10.2174/156720511795563764

Long-Term Response to Galantamine in Relation to Short-Term Efficacy Data: Pooled Analysis in Patients with Mild to Moderate Alzheimers Disease open Access plus

Volume: 8   Issue: 2
Pp: 175-186
S. Kavanagh, I. Howe, H. R. Brashear, D. Wang, B. Van Baelen, M. Todd and S. Schwalen
DOI:10.2174/156720511795256044

Baseline MRI Predictors of Conversion from MCI to Probable AD in the ADNI Cohort open Access plus

Volume: 6   Issue: 4
Pp: 347-361
Shannon L. Risacher, Andrew J. Saykin, John D. Wes, Li Shen, Hiram A. Firpi and Brenna C. McDonald
DOI:10.2174/156720509788929273

Towards Retinoid Therapy for Alzheimers Disease open Access plus

Volume: 6   Issue: 3
Pp: 302-311
K. Shudo, H. Fukasawa, M. Nakagomi and N. Yamagata
DOI:10.2174/156720509788486581

Natural Non-Trasgenic Animal Models for Research in Alzheimers Disease open Access plus

Volume: 6   Issue: 2
Pp: 171-178
Manuel Sarasa and Pedro Pesini
DOI:10.2174/156720509787602834

Long-Term Follow-Up of Patients Immunized with AN1792: Reduced Functional Decline in Antibody Responders open Access plus

Volume: 6   Issue: 2
Pp: 144-151
Bruno Vellas, R. Black, Leon J. Thal, Nick C. Fox, M. Daniels, G. McLennan, C. Tompkins, C. Leibman, M. Pomfret and Michael Grundman
DOI:10.2174/156720509787602852

Assembly of the Asparagine- and Glutamine-Rich Yeast Prions into Protein Fibrils open Access plus

Volume: 5   Issue: 3
Pp: 251-259
Luc Bousset, Jimmy Savistchenko and Ronald Melki
DOI:10.2174/156720508784533303

A New Glucocorticoid Hypothesis of Brain Aging: Implications for Alzheimers Disease open Access plus

Volume: 4   Issue: 2
Pp: 205-212
Philip W. Landfield, Eric M. Blalock, Kuey-Chu Chen and Nada M. Porter
DOI:10.2174/156720507780362083

De Novo and Molecular Target-Independent Discovery of Orally Bioavailable Lead Compounds for Neurological Disorders open Access plus

Volume: 3   Issue: 3
Pp: 205-214
Laura K. Wing, Heather A. Behanna, Linda J. Van Eldik, D. Martin Watterson and Hantamalala Ralay Ranaivo
DOI:10.2174/156720506777632844

Induction of RhoGAP and Pathological Changes Characteristic of Alzheimers Disease by UAHFEMF Discharge in Rat Brain open Access plus

Volume: 2   Issue: 5
Pp: 559-569
Ing-Feng Chang and Huo-Yen Hsiao
DOI:10.2174/156720505774932269