Current Alzheimer Research


Debomoy K. Lahiri  
Department of Psychiatry
Indiana University School of Medicine
Neuroscience Research Center
Indianapolis, IN 46202


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Editor's Choice

Role of Cdk5 in Amyloid-beta Pathology of Alzheimer’s Disease

Volume: 16   Issue: 13
Pp: 1206-1215
Tao-Tao Lu, Chengqun Wan, Wenming Yang* and Zhiyou Cai*
DOI: 10.2174/1567205016666191210094435

Increased Prevalence of Vestibular Loss in Mild Cognitive Impairment and Alzheimer’s Disease

Volume: 16   Issue: 12
Pp: 1143-1150
Eric X. Wei*, Esther S. Oh, Aisha Harun, Matthew Ehrenburg, Qian-Li Xue, Eleanor Simonsick and Yuri Agrawal
DOI: 10.2174/1567205016666190816114838

Alzheimer’s Disease and Retinal Degeneration: A Glimpse at Essential Trace Metals in Ocular Fluids and Tissues

Volume: 16   Issue: 12
Pp: 1073-1083
Alessandra Micera*, Luca Bruno, Andrea Cacciamani, Mauro Rongioletti and Rosanna Squitti
DOI: 10.2174/1567205016666191023114015

Monoamines and their Derivatives on GPCRs: Potential Therapy for Alzheimer’s Disease

Volume: 16   Issue: 10
Pp: 871-894
Eunice D. Farfán-García, Ricardo Márquez-Gómez, Mónica Barrón-González, Teresa Pérez-Capistran, Martha C. Rosales-Hernández, Rodolfo Pinto-Almazán and Marvin A. Soriano-Ursúa*
DOI: 10.2174/1570159X17666190409144558

Amyloid-β Oligomers-induced Mitochondrial DNA Repair Impairment Contributes to Altered Human Neural Stem Cell Differentiation

Volume: 16   Issue: 10
Pp: 934-949
Jing Lu, Yi Li, Cristiana Mollinari, Enrico Garaci, Daniela Merlo and Gang Pei*
DOI: 10.2174/1567205016666191023104036

Synthesis of a Novel Curcumin Derivative as a Potential Imaging Probe in Alzheimer’s Disease Imaging

Volume: 16   Issue: 8
Pp: 723-731
Alexander Sturzu, Sumbla Sheikh*, Hubert Kalbacher, Thomas Nägele, Christopher Weidenmaier, Bettina M. Wegenast-Braun, Nadine Schilling, Ulrike Ernemann and Stefan Heckl
DOI: 10.2174/1567205016666190816130516

Astrocytes: From the Physiology to the Disease

Volume: 16   Issue: 8
Pp: 675-698
Laura Trujillo-Estrada, Angela Gomez-Arboledas, Stefânia Forner, Alessandra Cadete Martini, Antonia Gutierrez, David Baglietto-Vargas* and Frank M. LaFerla*
DOI: 10.2174/1567205016666190830110152

Long Non-coding RNA MALAT1 Inhibits Neuron Apoptosis and Neuroinflammation While Stimulates Neurite Outgrowth and Its Correlation With MiR-125b Mediates PTGS2, CDK5 and FOXQ1 in Alzheimer's Disease open access plus

Volume: 16   Issue: 7
Pp: 596-612
Peizhi Ma, Yuanlong Li*, Wei Zhang, Fengqin Fang, Jun Sun, Mingzhou Liu, Kun Li and Lingfang Dong
DOI: 10.2174/1567205016666190725130134

High Contrast and Resolution Labeling of Amyloid Plaques in Tissue Sections from APP-PS1 Mice and Humans with Alzheimer’s Disease with the Zinc Chelator HQ-O: Practical and Theoretical Considerations open access plus

Volume: 16   Issue: 7
Pp: 577-586
Larry Schmued*, James Raymick and Sumit Sarkar
DOI: 10.2174/1567205016666190725155038

Strategies for the Recruitment and Retention of Racial/Ethnic Minorities in Alzheimer Disease and Dementia Clinical Research

Volume: 16   Issue: 5
Pp: 458-471
Roger Wong*, Takashi Amano, Shih-Yin Lin, Yuanjin Zhou and Nancy Morrow-Howell
DOI: 10.2174/1567205016666190321161901

Does Intraneuronal Accumulation of Carboxyl-terminal Fragments of the Amyloid Precursor Protein Trigger Early Neurotoxicity in Alzheimer’s Disease? open access plus

Volume: 16   Issue: 5
Pp: 453-457
I. Lauritzen, R. Pardossi-Piquard, A. Bourgeois, A. Bécot and F. Checler *
DOI: 10.2174/1567205016666190325092841

The Role of MAPK's Signaling in Mediating ApoE4-Driven Pathology In Vivo

Volume: 16   Issue: 4
Pp: 281-292
Shiran Salomon-Zimri, Amit Koren, Ariel Angel, Tali Ben-Zur, Daniel Offen and Daniel M. Michaelson*
DOI: 10.2174/1567205016666190228120254

Lead (Pb) in Alzheimer’s Dementia: A Systematic Review of Human Case- Control Studies

Volume: 16   Issue: 4
Pp: 353-361
Eric E. Brown, Parita Shah, Bruce G. Pollock, Philip Gerretsen and Ariel Graff-Guerrero*
DOI: 10.2174/1567205016666190311101445

Abnormal Sleep Behaviours Across the Spectrum of Alzheimer’s Disease Severity: Influence of APOE Genotypes and Lewy Bodies

Volume: 16   Issue: 3
Pp: 243-250
Ka Yi G. Koo, Tom A. Schweizer, Corinne E. Fischer and David G. Munoz*
DOI: 10.2174/1567205016666190103161034

Synthesis of New Galanthamine-Peptide Derivatives Designed for Prevention and Treatment of Alzheimer’s Disease

Volume: 16   Issue: 3
Pp: 183-192
Lyubomir T. Vezenkov*, Daniela S. Tsekova*, Ivanka Kostadinova, Rositsa Mihaylova, Nikolay G. Vassilev and Nikolai D. Danchev
DOI: 10.2174/1567205016666190228123923

Alzheimer’s Disease: Physical Activities as an Effective Intervention Tool - A Mini-Review

Volume: 16   Issue: 2
Pp: 166-171
Blanka Klimova, Petra Maresova and Kamil Kuca*
DOI: 10.2174/1567205015666181002132021

The Temporal Relationship between Pain Intensity and Pain Interference and Incident Dementia

Volume: 16   Issue: 2
Pp: 109-115
Ali Ezzati*, Cuiling Wang, Mindy J. Katz, Carol A. Derby, Andrea R. Zammit, Molly E. Zimmerman, Jelena M. Pavlovic, Martin J. Sliwinski and Richard B. Lipton
DOI: 10.2174/1567205016666181212162424

Impact of a Clinical Decision Support Tool on Dementia Diagnostics in Memory Clinics: The PredictND Validation Study open access plus

Volume: 16   Issue: 2
Pp: 91-101
Marie Bruun*, Kristian S. Frederiksen, Hanneke F.M. Rhodius-Meester, Marta Baroni, Le Gjerum, Juha Koikkalainen, Timo Urhemaa, Antti Tolonen, Mark van Gils, Tong Tong, Ricardo Guerrero, Daniel Rueckert, Nadia Dyremose, Birgitte Bo Andersen, Anja H. Simonsen, Afina Lemstra, Merja Hallikainen, Sudhir Kurl, Sanna-Kaisa Herukka, Anne M. Remes, Gunhild Waldemar, Hilkka Soininen, Patrizia Mecocci, Wiesje M. van der Flier, Jyrki Lötjönen and Steen G. Hasselbalch
DOI: 10.2174/1567205016666190103152425

Visual Event-Related Potentials in Mild Cognitive Impairment and Alzheimer’s Disease: A Literature Review

Volume: 16   Issue: 1
Pp: 67-89
Cassandra Morrison*, Sheida Rabipour, Vanessa Taler, Christine Sheppard and Frank Knoefel
DOI: 10.2174/1567205015666181022101036

Intranasal Insulin Prevents Anesthesia-induced Cognitive Impairments in Aged Mice

Volume: 16   Issue: 1
Pp: 8-18
Xing Li, Xiaoqin Run*, Zhen Wei, Kuan Zeng, Zhihou Liang, Fang Huang, Dan Ke, Qun Wang, Jian-Zhi Wang, Rong Liu, Bin Zhang* and Xiaochuan Wang*
DOI: 10.2174/1567205015666181031145045

Stroke as a Cause of Death in Death Certificates of Patients with Dementia: A Cohort Study from the Swedish Dementia Registry open access plus

Volume: 15   Issue: 14
Pp: 1322-1330
Ana Subic*, Eva Zupanic, Mia von Euler, Bo Norrving, Pavla Cermakova, Dorota Religa, Bengt Winblad, Milica G. Kramberger, Maria Eriksdotter and Sara Garcia-Ptacek
DOI: 10.2174/1567205015666181002134155

Microdose Lithium NP03 Diminishes Pre-Plaque Oxidative Damage and Neuroinflammation in a Rat Model of Alzheimer’s-like Amyloidosis

Volume: 15   Issue: 13
Pp: 1220-1230
Edward N. Wilson, Sonia Do Carmo, M. Florencia Iulita, Hélène Hall, Grant L. Austin, Dan T. Jia, Janice C. Malcolm, Morgan K. Foret, Adam R. Marks, D. Allan Butterfield and A. Claudio Cuello*
DOI: 10.2174/1567205015666180904154446

Influence of Early Life Lead (Pb) Exposure on α-Synuclein, GSK-3β and Caspase-3 Mediated Tauopathy: Implications on Alzheimer’s Disease

Volume: 15   Issue: 12
Pp: 1114-1122
Syed Waseem Bihaqi, Bothaina Alansi, Anwar M. Masoud, Foqia Mushtaq, Gehad M. Subaiea and Nasser H. Zawia *
DOI: 10.2174/1567205015666180801095925

Probiotic Supplementation in Patients with Alzheimer’s Dementia - An Explorative Intervention Study open access plus

Volume: 15   Issue: 12
Pp: 1106-1113
Friedrich Leblhuber, Kostja Steiner, Burkhard Schuetz, Dietmar Fuchs* and Johanna M. Gostner
DOI: 10.2174/1389200219666180813144834

Ezrin Expression is Increased During Disease Progression in a Tauopathy Mouse Model and Alzheimer’s Disease

Volume: 15   Issue: 12
Pp: 1086-1095
Irving E. Vega*, Andrew Umstead, Cassandra M. Wygant, John S. Beck and Scott E. Counts*
DOI: 10.2174/1567205015666180813152043

Transcriptional Remodeling in Primary Hippocampal Astrocytes from an Alzheimer’s Disease Mouse Model

Volume: 15   Issue: 11
Pp: 986-1004
F. Ruffinatti, L. Tapella, I. Gregnanin, A. Stevano, G. Chiorino, P.L. Canonico, C. Distasi, A.A. Genazzani* and D. Lim*
DOI: 10.2174/1567205015666180613113924

Hippocampal Mean Diffusivity for the Diagnosis of Dementia and Mild Cognitive Impairment in Primary Care

Volume: 15   Issue: 11
Pp: 1005-1012
Katharina Brueggen*, Martin Dyrba, Ingo Kilimann, Judith Henf, Wolfgang Hoffmann, Jochen R. Thyrian and Stefan Teipel
DOI: 10.2174/1567205015666180613114829

Association Between Atrophy of the Caudate Nuclei, Global Brain Atrophy, Cerebral Small Vessel Disease and Mild Parkinsonian Signs in Neurologically and Cognitively Healthy Subjects Aged 45-84 Years: A Crosssectional Study

Volume: 15   Issue: 11
Pp: 1013-1026
Cecilia Camarda*, Paola Torelli, Carmela Pipia, Iacopo Battaglini, Delia Azzarello, Rosamaria Rosano, Giusi Daniela Ventimiglia, Gianluca Sottile, Giovanna Cilluffo and Rosolino Camarda
DOI: 10.2174/1567205015666180702111110

Short-Term Response to Cholinesterase Inhibitors in Alzheimer’s Disease Delays Time to Nursing Home Placement open access plus

Volume: 15   Issue: 10
Pp: 905-916
Carina Wattmo*, Elisabet Londos and Lennart Minthon
DOI: 10.2174/1567205015666180507105326

Interplay between the APOE Genotype and Possible Plasma Biomarkers in Alzheimer’s Disease open access plus

Volume: 15   Issue: 10
Pp: 938-950
Martina Zverova, Eva Kitzlerova, Zdenek Fisar*, Roman Jirak, Jana Hroudova, Hana Benakova, Petra Lelkova, Pavel Martasek and Jiri Raboch
DOI: 10.2174/1567205015666180601090533

Strategies for Continued Successful Treatment in Patients with Alzheimer’s Disease: An Overview of Switching Between Pharmacological Agents open access plus

Volume: 15   Issue: 10
Pp: 964-974
Rafael Blesa, Kazuhiro Toriyama*, Kengo Ueda, Sean Knox and George Grossberg
DOI: 10.2174/1567205015666180613112040

(-)-Phenserine and Inhibiting Pre-Programmed Cell Death: In Pursuit of a Novel Intervention for Alzheimer’s Disease

Volume: 15   Issue: 9
Pp: 883-891
Robert E. Becker*, Nigel H. Greig, Debomoy K. Lahiri, Joseph Bledsoe, Sarah Majercik, Clive Ballard, Dag Aarsland, Lon S. Schneider, Douglas Flanagan, Ramprakash Govindarajan, Mary Sano, Luigi Ferrucci and Dimitrios Kapogiannis
DOI: 10.2174/1567205015666180110120026

Memorization Test and Resting State EEG Components in Mild and Subjective Cognitive Impairment

Volume: 15   Issue: 9
Pp: 809-819
Giulia Mazzon*, Federica De Dea, Tatiana Cattaruzza, Paolo Manganotti, Fabrizio Monti and Agostino Accardo
DOI: 10.2174/1567205015666180427114520

Semantic Intrusions and Failure to Recover From Semantic Interference in Mild Cognitive Impairment: Relationship to Amyloid and Cortical Thickness

Volume: 15   Issue: 9
Pp: 848-855
Rosie E. Curiel, David A. Loewenstein*, Monica Rosselli, Ailyn Penate, Maria T. Greig-Custo, Russell M. Bauer, Salvador M. Guinjoan, Kevin S. Hanson, Chunfei Li, Gabriel Lizarraga, William W. Barker, Valeria Torres, Steven DeKosky, Malek Adjouadi and Ranjan Duara
DOI: 10.2174/1567205015666180427122746

Treponema, Iron and Neurodegeneration

Volume: 15   Issue: 8
Pp: 716-722
A. Jolivet-Gougeon* and M. Bonnaure-Mallet
DOI: 10.2174/1567205013666161122093404

Estimating Alzheimer’s Disease Progression Rates from Normal Cognition Through Mild Cognitive Impairment and Stages of Dementia

Volume: 15   Issue: 8
Pp: 777-788
Matthew Davis, Thomas O`Connell, Scott Johnson, Stephanie Cline*, Elizabeth Merikle, Ferenc Martenyi and Kit Simpson
DOI: 10.2174/1567205015666180119092427

Tolfenamic Acid Prevents Amyloid β-induced Olfactory Bulb Dysfunction In Vivo

Volume: 15   Issue: 8
Pp: 731-742
José M. Cornejo-Montes-de-Oca, Rebeca Hernández-Soto, Arturo G. Isla, Carlos E. Morado-Urbina and Fernando Peña-Ortega*
DOI: 10.2174/1567205015666180223091233

Tolfenamic Acid: A Modifier of the Tau Protein and its Role in Cognition and Tauopathy

Volume: 15   Issue: 7
Pp: 655-663
Joanna K. Chang, Allison Leso, Gehad M. Subaiea, Asma Lahouel, Anwar Masoud, Foqia Mushtaq, Reem Deeb, Aseel Eid, Miriam Dash , Syed W. Bihaqi and Nasser H. Zawia*
DOI: 10.2174/1567205015666180119104036

Melatonin Treatment Enhances Aβ Lymphatic Clearance in a Transgenic Mouse Model of Amyloidosis

Volume: 15   Issue: 7
Pp: 637-642
M.A. Pappolla*, E. Matsubara, R. Vidal, J. Pacheco-Quinto, B. Poeggeler, M. Zagorski and K. Sambamurti
DOI: 10.2174/1567205015666180411092551

Up-regulation of DMN Connectivity in Mild Cognitive Impairment Via Network-based Cognitive Training open access plus

Volume: 15   Issue: 6
Pp: 578-589
Matteo De Marco, Francesca Meneghello, Cristina Pilosio, Jessica Rigon and Annalena Venneri*
DOI: 10.2174/1567205015666171212103323

Is it All Said for NSAIDs in Alzheimer’s Disease? Role of Mitochondrial Calcium Uptake

Volume: 15   Issue: 6
Pp: 504-510
Sara Sanz-Blasco, Maria Calvo-Rodríguez, Erica Caballero, Monica Garcia-Durillo, Lucia Nunez and Carlos Villalobos*
DOI: 10.2174/1567205015666171227154016

Vitamin D Increases Aβ140 Plasma Levels and Protects Lymphocytes from Oxidative Death in Mild Cognitive Impairment Patients

Volume: 15   Issue: 6
Pp: 561-569
Carol D. SanMartín, Mauricio Henriquez, Carlos Chacon, Daniela P. Ponce, Felipe Salech, Nicole K. Rogers and Maria I. Behrens*
DOI: 10.2174/1567205015666171227154636

Quality of Life in Dementia Sufferers: The Role of Diet and Exercise

Volume: 15   Issue: 5
Pp: 400-407
Pasquale Ricci, Francesco Massoni*, Lidia Ricci, Emanuela Onofri, Giuseppe Donato and Serafino Ricci
DOI: 10.2174/1567205014666170925151614

A Biomarker Combining Imaging and Neuropsychological Assessment for Tracking Early Alzheimer's Disease in Clinical Trials

Volume: 15   Issue: 5
Pp: 429-442
Nishant Verma, S. Natasha Beretvas, Belen Pascual, Joseph C. Masdeu, Mia K. Markey* and The Alzheimer's Disease Neuroimaging Initiative
DOI: 10.2174/1567205014666171106150309

The Correlations between Postmortem Brain Pathologies and Cognitive Dysfunction in Aging and Alzheimer's Disease

Volume: 15   Issue: 5
Pp: 462-473
Wen-Ying Qiu, Qian Yang, Wanying Zhang, Naili Wang, Di Zhang, Yue Huang* and Chao Ma*
DOI: 10.2174/1567205014666171106150915

Cognitive Training in Patients with Alzheimer's Disease: Findings of a 12-month Randomized Controlled Trial

Volume: 15   Issue: 5
Pp: 452-461
Alessandro Trebbastoni*, Letizia Imbriano, Livia Podda, Lidia Rendace, Maria Luisa Sacchett, Alessandra Campanelli, Fabrizia D’Antonio and Carlo de Lena
DOI: 10.2174/1567205014666171113105044

Modulation of Inflammation as a Way of Delaying Alzheimer's Disease Progression: The Diet's Role

Volume: 15   Issue: 4
Pp: 363-380
R. Businaro*, M. Corsi, R. Asprino, C. Di Lorenzo, D. Laskin, R.M. Corbo, S. Ricci and A. Pinto
DOI: 10.2174/1567205014666170829100100

Pharmacogenetics of Angiotensin-Converting Enzyme Inhibitors in Patients with Alzheimer's Disease Dementia

Volume: 15   Issue: 4
Pp: 386-398
Fabricio Ferreira de Oliveira*, Elizabeth Suchi Chen, Marilia Cardoso Smith and Paulo Henrique Ferreira Bertolucci
DOI: 10.2174/1567205014666171016101816

Erythrocyte Associated Amyloid-β as Potential Biomarker to Diagnose Dementia

Volume: 15   Issue: 4
Pp: 381-385
Michele Lauriola, Giulia Paroni*, Filomena Ciccone, Grazia D`Onofrio, Leandro Cascavilla, Francesco Paris, Carolina Gravina, Maria Urbano, Davide Seripa and Antonio Greco
DOI: 10.2174/1567205014666171110160556

Ongoing Electroencephalographic Activity Associated with Cortical Arousal in Transgenic PDAPP Mice (hAPP V717F)

Volume: 15   Issue: 3
Pp: 259-272
Claudio Del Percio, Wilhelmus Drinkenburg, Susanna Lopez, Cristina Limatola, Jesper F. Bastlund, Ditte Z. Christensen, Jan T. Pedersen, Gianluigi Forloni, Angelisa Frasca, Francesco M. Noe, Marina Bentivoglio, Paolo F. Fabene, Giuseppe Bertini, Valeria Colavito, Sophie Dix, Raffaele Ferri, Regis Bordet, Jill C. Richardson and Claudio Babiloni*
DOI: 10.2174/1567205014666170704113405

Map Learning in Normal Aging: The Role of Individual Visuo-Spatial Abilities and Implications

Volume: 15   Issue: 3
Pp: 205-218
Chiara Meneghetti*, Veronica Muffato, Erika Borella and Rossana De Beni
DOI: 10.2174/1567205014666171030113515

Allocentric to Egocentric Spatial Switching: Impairment in aMCI and Alzheimer's Disease Patients?

Volume: 15   Issue: 3
Pp: 229-236
Gennaro Ruggiero*, Alessandro Iavarone and Tina Iachini
DOI: 10.2174/1567205014666171030114821

CDK5 and MAPT Gene Expression in Alzheimer's Disease Brain Samples

Volume: 15   Issue: 2
Pp: 182-186
Josianne T. Fukasawa, Roger W. de Labio, Lucas T. Rasmussen, Lucieni C. de Oliveira, Elizabeth Chen, Joao Villares, Gustavo Tureck, Marilia de Arruda C. Smith and Spencer L.M. Payao*
DOI: 10.2174/1567205014666170713160407

Use of Speech Analyses within a Mobile Application for the Assessment of Cognitive Impairment in Elderly People

Volume: 15   Issue: 2
Pp: 120-129
Alexandra Konig*, Aharon Satt, Alex Sorin, Ran Hoory, Alexandre Derreumaux, Renaud David and Phillippe H. Robert
DOI: 10.2174/1567205014666170829111942

Body Mass Index (BMI) and Cognitive Functions in Later Life

Volume: 15   Issue: 2
Pp: 195-200
Yadollah A. Momtaz, Sharifah A. Haron, Tengku A. Hamid, Rahimah Ibrahim and Parisa T. Tanjani*
DOI: 10.2174/1567205014666171004114246

Alzheimer's Disease and NQO1: Is there a Link? promotion: free to download

Volume: 15   Issue: 1
Pp: 56-66
Jamuna Chhetri*, Anna E. King and Nuri Gueven
DOI: 10.2174/1567205014666170203095802

Ginkgo biloba Extract EGb761 Attenuates Hyperhomocysteinemia-induced AD Like Tau Hyperphosphorylation and Cognitive Impairment in Rats promotion: free to download

Volume: 15   Issue: 1
Pp: 89-99
Kuan Zeng, Mengzhu Li, Jichang Hu, Yacoubou Abdoul Razak Mahaman, Jian Bao, Fang Huang, Yiyuan Xia, Xinghua Liu, Qun Wang, Jian-Zhi Wang, Yang Yang, Rong Liu and Xiaochuan Wang*
DOI: 10.2174/1567205014666170829102135

The Clock Drawing Test: A Reasonable Instrument to Assess Probable Dementia in Primary Care? promotion: free to download

Volume: 15   Issue: 1
Pp: 38-43
Katinka Reiner, Tilly Eichler, Johannes Hertel, Wolfgang Hoffmann and Jochen Rene Thyrian*
DOI: 10.2174/1567205014666170908101822

Antioxidant SkQ1 Alleviates Signs of Alzheimer’s Disease-like Pathology in Old OXYS Rats by Reversing Mitochondrial Deterioration

Volume: 14   Issue: 12
Pp: 1283-1292
Nataliya G. Kolosova*, Mikhail A. Tyumentsev, Natalia A. Muraleva, Elena Kiseleva, Anton O. Vitovtov and Natalia A. Stefanova*
DOI: 10.2174/1567205014666170621111033

Patients with Increased Non-Ceruloplasmin Copper Appear a Distinct Sub-Group of Alzheimer's Disease: A Neuroimaging Study

Volume: 14   Issue: 12
Pp: 1318-1326
Rosanna Squitti*, Ilaria Simonelli, Emanuele Cassetta, Domenico Lupoi, Mauro Rongioletti, Mariacarla Ventriglia and Mariacristina Siotto
DOI: 10.2174/1567205014666170623125156