Abstract
Selective Serotonin reuptake inhibitors (SSRIs) have contributed to the major advances in the treatment of depression and other psychiatric diseases. This review summarises current knowledge concerning the SSRI class of drugs and discusses the importance of secondary pharmacology in the mechanism of action and effectiveness of these drugs. Particular attention is given to the emerging importance of the SSRI ‘plus’ approach: where the serotonin reuptake receptor inhibition of a drug is supplemented by one or more other receptor interactions either by the same drug or by a combination therapy. This area of research has shed light on the pharmacological mechanisms of SSRI therapy and has the therapeutic usefulness of serotonin reuptake inhibition, especially in the area of depression. There are many new emerging SSRI ‘plus’ drugs, which address the pharmacological and pharmacokinetic issues of current therapies and these, are discussed in detail.
Keywords: serotonin reuptake inhibition, selective serotonin reuptake inhibitors, psychiatric diseases, combination therapy, amit, citalopram, paroxetine, fluvoxamine, sertraline, pindolol
Current Medicinal Chemistry
Title: Serotonin Reuptake Inhibition: An Update on Current Research Strategies
Volume: 9 Issue: 8
Author(s): D. Spinks and G. Spinks
Affiliation:
Keywords: serotonin reuptake inhibition, selective serotonin reuptake inhibitors, psychiatric diseases, combination therapy, amit, citalopram, paroxetine, fluvoxamine, sertraline, pindolol
Abstract: Selective Serotonin reuptake inhibitors (SSRIs) have contributed to the major advances in the treatment of depression and other psychiatric diseases. This review summarises current knowledge concerning the SSRI class of drugs and discusses the importance of secondary pharmacology in the mechanism of action and effectiveness of these drugs. Particular attention is given to the emerging importance of the SSRI ‘plus’ approach: where the serotonin reuptake receptor inhibition of a drug is supplemented by one or more other receptor interactions either by the same drug or by a combination therapy. This area of research has shed light on the pharmacological mechanisms of SSRI therapy and has the therapeutic usefulness of serotonin reuptake inhibition, especially in the area of depression. There are many new emerging SSRI ‘plus’ drugs, which address the pharmacological and pharmacokinetic issues of current therapies and these, are discussed in detail.
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Cite this article as:
Spinks D. and Spinks G., Serotonin Reuptake Inhibition: An Update on Current Research Strategies, Current Medicinal Chemistry 2002; 9 (8) . https://dx.doi.org/10.2174/0929867024606795
DOI https://dx.doi.org/10.2174/0929867024606795 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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