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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Synthesis of Fluoroalkyl Substituted Heterocycles Using Fluorinecontaining Building Blocks

Author(s): S. Z. Zhu, Y. L. Wang, W. M. Peng, L. P. Song and G. F. Jin

Volume 6, Issue 12, 2002

Page: [1057 - 1096] Pages: 40

DOI: 10.2174/1385272023373635

Price: $65

Abstract

This review deals with recent progress in the synthesis of fluorine-containing heterocyclic compounds using the fluorinated building block method. Several fundamental fluorinated building blocks such as fluorinecontaining multiple bond compounds, fluoroalkyl substituted carbonyl compounds are described in detail, they are readily prepared and easy to scale up from the commercial available starting materials such as RfX, RfCXYZ (X, Y, Z: halogen), (CF3CO)2O etc. Under mild reaction condition, they react with various organic reagents to give a variety fluoroalkyl substituted N, S, O-heterocycles.

Keywords: Fluoroalkyl, Heterocycles, alkenes and alkynes, 3-Fluoro-3-Fluoroalkylacrylates, pyridinum


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