Abstract
Recent advances in growth factor therapy for the treatment of ischemic disease of the heart and peripheral vasculature offer hope for a novel strategy that is based on the generation of a new blood supply. Members of the fibroblast growth factor and vascular endothelial growth factor families and several other molecules have all been shown to induce significant angiogenesis in animal models of acute or chronic, myocardial or peripheral ischemia. In addition, it is known that arteries from specific regions in the arterial tree have various developmental origins. This may be one explanation for why arteries of different parts of the arterial tree undergo differential changes during the pathogenesis of vascular disease. There is speculation over several fundamental questions concerning the origin of vessel wall cells and the mechanisms that regulate their development and differentiation. Here we discuss what is known to date about the differential developmental origin of arteries and the possible consequences for therapeutic angiogenesis.
Keywords: ischemic disease, fibroblast growth, disrupted cell contact, hematopoietic progenitors, smooth muscle cells, mesodermal tissue, cytoskeletal markers desmin, vascular endothelial cells, mesenchymal transition failures, angiogenic processes
Current Medicinal Chemistry
Title: Vasculogenesis and Angiogenesis Depend on the Developmental Origin in the Arterial Tree
Volume: 9 Issue: 17
Author(s): Masumi Shimizu, Jaroslav Pelisek and Sigrid Nikol
Affiliation:
Keywords: ischemic disease, fibroblast growth, disrupted cell contact, hematopoietic progenitors, smooth muscle cells, mesodermal tissue, cytoskeletal markers desmin, vascular endothelial cells, mesenchymal transition failures, angiogenic processes
Abstract: Recent advances in growth factor therapy for the treatment of ischemic disease of the heart and peripheral vasculature offer hope for a novel strategy that is based on the generation of a new blood supply. Members of the fibroblast growth factor and vascular endothelial growth factor families and several other molecules have all been shown to induce significant angiogenesis in animal models of acute or chronic, myocardial or peripheral ischemia. In addition, it is known that arteries from specific regions in the arterial tree have various developmental origins. This may be one explanation for why arteries of different parts of the arterial tree undergo differential changes during the pathogenesis of vascular disease. There is speculation over several fundamental questions concerning the origin of vessel wall cells and the mechanisms that regulate their development and differentiation. Here we discuss what is known to date about the differential developmental origin of arteries and the possible consequences for therapeutic angiogenesis.
Export Options
About this article
Cite this article as:
Shimizu Masumi, Pelisek Jaroslav and Nikol Sigrid, Vasculogenesis and Angiogenesis Depend on the Developmental Origin in the Arterial Tree, Current Medicinal Chemistry 2002; 9 (17) . https://dx.doi.org/10.2174/0929867023369321
DOI https://dx.doi.org/10.2174/0929867023369321 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Recent Developments of C-Aryl Glucoside SGLT2 Inhibitors
Current Medicinal Chemistry Third and Fourth Generation Fluoroquinolone Antibacterials: A Systematic Review of Safety and Toxicity Profiles
Current Drug Safety Is Peri-Operative Isolated Systolic Hypertension (ISH) a Cardiac Risk Factor?
Current Cardiology Reviews Dyspnea in Cancer Patients: A Well-Known and Neglected Symptom
Reviews on Recent Clinical Trials Recent Advances in Polymer-based Wound Dressings for the Treatment of Diabetic Foot Ulcer: An Overview of State-of-the-art
Current Drug Targets Pathophysiology of Hypertension During Preeclampsia: Role of Inflammatory Cytokines
Current Hypertension Reviews Aldose Reductase, Oxidative Stress and Diabetic Cardiovascular Complications
Cardiovascular & Hematological Agents in Medicinal Chemistry Vulnerable Atherosclerotic Plaque: Clinical Implications
Current Vascular Pharmacology Biodegradable and Bioabsorbable Stents
Current Pharmaceutical Design Genetic Variability of Matrix Metalloproteinase Genes in Cardiovascular Disease
Current Topics in Medicinal Chemistry Cocaine and Acute Vascular Diseases
Current Drug Abuse Reviews Interconnection of Estrogen/Testosterone Metabolism and Mevalonate Pathway in Breast and Prostate Cancers
Current Molecular Pharmacology Aliskiren: A Novel Renin Inhibitor for Hypertension
Current Drug Therapy The State of the Problem of Achieving Extremely Low LDL Levels
Current Pharmaceutical Design An Overview: Current Systemic Therapies for Advanced Non-Small Cell Lung Cancer
Current Respiratory Medicine Reviews Recent Advancements in Pharmacological Stent Therapy Using Polymeric Materials: Opportunities and Challenges
Current Drug Delivery Leptin and Vascular Smooth Muscle Cells
Current Pharmaceutical Design BHUx: A Patented Polyherbal Formulation to Prevent Hyperlipidemia and Atherosclerosis
Recent Patents on Inflammation & Allergy Drug Discovery Pulmonary Hypertension and Right Ventricular Dysfunction in Chronic Lung Diseases: New Pathobiologic Concepts
Current Respiratory Medicine Reviews Platelets in Atherothrombosis: New and Evolving Roles
Current Pharmaceutical Design