Abstract
This review treats the mechanism of nitric oxide, catecholamines, and glutamate as important neurotransmitters and as neurotoxins, based on involvement of reactive oxygen species (ROS) and electron transfer (ET). ROS and ET can serve as a unifying framework for both transmission and toxicity, with ROS concentration being a crucial issue. Cell signaling, electrochemistry, antioxidants, and apoptosis are also discussed.
Keywords: nitric oxide, catecholamines, glutamate, neurotransmission, neurotoxicity, oxidative stress, reactive oxygen species
Current Medicinal Chemistry
Title: Neurotransmission and Neurotoxicity by Nitric Oxide, Catecholamines, and Glutamate: Unifying Themes of Reactive Oxygen Species and Electron Transfer
Volume: 10 Issue: 24
Author(s): Jason D. Jacintho and Peter Kovacic
Affiliation:
Keywords: nitric oxide, catecholamines, glutamate, neurotransmission, neurotoxicity, oxidative stress, reactive oxygen species
Abstract: This review treats the mechanism of nitric oxide, catecholamines, and glutamate as important neurotransmitters and as neurotoxins, based on involvement of reactive oxygen species (ROS) and electron transfer (ET). ROS and ET can serve as a unifying framework for both transmission and toxicity, with ROS concentration being a crucial issue. Cell signaling, electrochemistry, antioxidants, and apoptosis are also discussed.
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Cite this article as:
Jacintho D. Jason and Kovacic Peter, Neurotransmission and Neurotoxicity by Nitric Oxide, Catecholamines, and Glutamate: Unifying Themes of Reactive Oxygen Species and Electron Transfer, Current Medicinal Chemistry 2003; 10 (24) . https://dx.doi.org/10.2174/0929867033456404
DOI https://dx.doi.org/10.2174/0929867033456404 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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