Endocrine, Metabolic & Immune Disorders - Drug Targets

(Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders)

Editor-in-Chief

Emilio Jirillo
Department of Basic Medical Sciences Neuroscience and Sensory Organs
University of Bari “Aldo Moro”
Bari
(Italy)

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Articles Ahead of Print

TLRs Play Crucial Roles in Regulating RA Synoviocyte

Volume:20
Xuling Luo, Juncheng Cui, Xin Long and Zhiwei Chen*

Positive Correlation between Circulating Fetuin A and Severity of Coronary Artery Disease in Military Males

Volume:20
Reza Afrisham, Maliheh Paknejad, Davod Ilbeigi, Sahar Sadegh-Nejadi, Sattar Gorgani-Firuzjaee and Mahmoud Vahidi*

Molecular and Immunological Mechanisms Underlying the Various Pharmacological Properties of the Potent Bioflavonoid, Rutin

Volume:20
David Ong Cherk Yong, Sanggetha Raja Saker, Dinesh Kumar Chellappan*, Thiagarajan Madheswaran, Jithendra Panneerselvam, Hira Choudhury, Manisha Pandey, Yik Lung Chan, Trudi Collet, Gaurav Gupta, Brian G Oliver, Peter Wark, Nicole Hansbro, Alan Hsu, Philip Michael Hansbro, Kamal Dua and Farrukh Zeeshan

Thrombopoietin Receptor Agonists in Children with Immune Thrombocytopenia: A New Therapeutic Era

Volume:20
Giuseppe Lassandro, Valentina Palladino, Giovanni Carlo Del Vecchioa, Viviana Valeria Palmieri, Paola Carmela Corallo, Maria Felicia Faienza and Paola Giordano*

Gene Therapy for Prostate Cancer: A Review

Volume:20
Swapnil S. Talkar and Vandana B. Patravale*

How does Diabetes Impair Penile Tissues during Erectile Dysfunction?

Volume:20
Yi-Xing Wu, Chun-Tao Yang, Na Li, Xue Zheng, Xiang Li, Hui Zhang and Jie Shen*

Increased Circulatory Extrarenal 1α,25-Dihydroxyvitamin D3 in Bilaterally Nephrectomized Rats.

Volume:20
Murat Dabak*, Durrin Ozlem Dabak, Tuncay Kuloglu, Ersoy Baydar, Hakan Bulut and Ozgur Ozoner

Agammaglobulinemia: Epidemiology, Pathogenesis, Clinical Phenotype, Diagnosis, Prognosis and Management

Volume:20
Salar Pashangzadeh, Reza Yazdani, Farzad Nazari, Gholamreza Azizi, Hassan Abolhassani and Asghar Aghamohammadi*

The shift of HbF to HbA under Influence of SKA2 Gene; A Possible Link between Cortisol and Hematopoietic Maturation in Term and Preterm Newborns

Volume:20
Janat Ijabi, Reza Afrisham, Hemen Moradi-Sardareh, Parisa Roozehdar, Fatemeh Seifi, Amirhossein Sahebkar and Roghayeh Ijabi*

Continuous Hypoxia and Glucose Metabolism: The Effects on Gene Expression in Mcf7 Breast Cancer Cell Line

Volume:20
Abdel Qader Al Bawab, Malek Zihlif*, Yazan Jarrar and Ahmad Sharab

A Pre-Post Study of Vitamin D Supplements effects on Urinary megalin: The emerging predictive role of megalin in diabetic nephropathy progression

Volume:20
Violet Kasabri*, Amal Akour, Nailya Bulatova, Maysa Suyagh, Al Motassem Yousef, Hussein Al Hawari, Sameeha Al Shelleh, Jameel Bzour and Hiba Fahmawi

T Cell Proliferative Responses and IgG Antibodies to β2GPI in Patients with Diabetes and Atherosclerosis

Volume:20
Mohammad Rafiee Monjezi, Hamed Fouladseresht, Shirin Farjadian, Behrouz Gharesi-Fard, Shahdad Khosropanah and Mehrnoosh Doroudchi*

Anti-Inflammatory Effects of Plasma Circulating Exosomes Obtained from Normal-Weight and Obese Subjects on Hepatocytes

Volume:20
Reza Afrisham, Sahar Sadegh-Nejadi, Reza Meshkani, Solaleh Emamgholipour, Molood Bagherieh and Maliheh Paknejad*

Gastrointestinal Side Effects of Triple Immunosuppressive Therapy Evaluated by AC Biosusceptometry and Electrogastrography in Rats

Volume:20
Denize Jussara Rupolo Dall’Agnol, Luciana Aparecida Corá, Loyane Almeida Gama, Romero Santos Caló, José Ricardo Arruda Miranda and Madileine Francely Américo*

Insights into Transdermal Drug Delivery: Approaches for Redressal of a Burgeoning Issue of Osteoporosis

Volume:20
Foziyah Zakir, Kanchan Kohli*, Farhan J. Ahmad, Zeenat Iqbal and Adil Ahmad

The Cannabis spread throughout the Continents and its therapeutic use in history

Volume:20
Ioannis Alexandros Charitos, Roberto Gagliano-Candela, Luigi Santacroce* and Lucrezia Bottalico

Oxytocin Signaling Pathway: From Cell Biology To Clinical Implications.

Volume:20
Michele Iovino*, Tullio Messana, Anna Tortora, Consuelo Giusti, Giuseppe Lisco, Vito Angelo Giagulli, Edoardo Guastamacchia, Giovanni De Pergola and Vincenzo Triggiani

Dual Role of microRNAs in Autophagy of Colorectal Cancer

Volume:20
Tanu Sharma, James A. Radosevich and Chandi C. Mandal*

Impact of Interleukin 28B and ICAM-1 Genetic Polymorphisms on Response to Direct Antiviral Treatment Among HCV Infected Patients

Volume:20
Amel G. Elsheredy, Abdulrahman H. Almaeen, Amany A. Ghazy*, Ghada F. Helaly, Ibrahim Amer, Haneen A. Ghazy and Tamer Haydara

Oral Alpha Lipoic Acid Treatment for Symptomatic Diabetic Peripheral Neuropathy: A Randomized Double-Blinded Placebo-Controlled Study

Volume:20
Mamdouh R. El-Nahas, Ghada Elkannishy, Hala Abdelhafez, Enas T. Elkhamisy and Amr A. El-Sehrawy*

IFN-γ and TNF-α Gene Polymorphisms in Multiple Sclerosis Patients in Northwest Iran

Volume:20
Mohammad Asgharzadeh, Nima Najafi-Ghalehlou, Behroz Mahdavi Poor, Vahid Asgharzadeh, Mahya Pourostadi, Ali Vegari, Hossein Samadi Kafil, Manouchehr Fadaee, Mehdi Farhoudi and Jalil Rashedi*

Chronic Pancreatitis and the Development of Pancreatic Cancer

Volume:20
Hemanth K. Kandikattu, Sathisha U. Venkateshaiah and Anil Mishra*

Analysis of Interleukin-1 Receptor Antagonist Variable Number Tandem Repeat Variant in Recurrent Aphthous Stomatitis

Volume:20
Akin Tekcan, Serbulent Yigit*, Ayse F. Nursal, Mehmet K. Tumer, Kaan Yerliyurt and Nilufer Kuruca

Theranostic Nanoparticles for Pancreatic Cancer Treatment

Volume:20
LR Jaidev*, Laxmi Shanthi Chede and Hemanth Kumar Kandikattu

Effect of Mirabegron on the Body's Exercise Capacity: A Review

Volume:20
Kamil Leis, Ewelina Mazur, Mariusz Racinowski, Wojciech Świerczyński, Aleksandra Baska* and Przemysław Gałązka

MicroRNAs as Biomarker for Breast Cancer

Volume:20
Taru Aggarwal, Ridhima Wadhwa, Riya Gupta, Trudi Collet, Dinesh Kumar Chellapan, Gaurav Gupta, Haribalan Perumalsamy, Meenu Mehta, Saurabh Satija*, Philip M. Hansbro, Kamal Dua and Pawan Kumar Maurya

Promising Use Of The New Biologics In The Management Of Drug-Induced Hypersensitivity Reactions: Preliminary Approaches

Volume:20
Gianfranco Calogiuri*, Knut Brockow, Eustachio Nettis, Luigi Macchia, Caterina Foti and Angelo Vacca

Obesity: the New Global Epidemic. Pharmacological Treatment, Opportunities and Limits for Personalized Therapy.

Volume:20
Walter Milano, Valeria De Biasio, Walter Di Munzio, Giuseppina Foggia and Anna Capasso*

The Relationship between Diet and Frailty in Aging

Volume:20
Lucia Gimeno-Mallench, Elisa Sanchez-Morate, Sergi Parejo-Pedrajas, Cristina Mas-Bargues, Marta Inglés, Jorge Sanz-Ros, Aurora Román-Domínguez, Gloria Olaso, Kristine Stromsnes and Juan Gambini*

Hydroethanolic Extract of Lampaya Medicinalis Phil. (Verbenaceae) Decreases Proinflammatory Marker Expression in Palmitic Acid-exposed Macrophages

Volume:20
Paulina Ormazabal*, Mariana Cifuentes, Rosaria Varì, Beatrice Scazzocchio, Roberta Masella, Igor Pacheco, Wladimir Vega, Adrián Paredes and Glauco Morales

Autumn Royal and Egnatia Grape Extracts Differently Modulate Cell Proliferation in Human Colorectal Cancer Cells

Volume:20
Isabella Gigante, Rosa Anna Milella, Valeria Tutino, Giambattista Debiase, Luciano Notarangelo, Maria Angela Giannandrea, Valentina De Nunzio, Antonella Orlando, Rosalba D’Alessandro, Maria Gabriella Caruso and Maria Notarnicola*

COX and PTGDS Gene Expression Levels in PGD2 Synthesis Pathway are correlated with miR-520 in Patients with Vessel Restenosis

Volume:20
Shima Rezaee, Naser Kakavandi, Mohammad Shabani*, Mohsen Khosravi, Seyed R. Hosseini-Fard and Mohammad Najafi*

Higher Body Mass Index, Uric Acid Levels, and Lower Cholesterol Levels are Associated with Greater Weight Loss

Volume:20
Giovanni De Pergola*, Roberta Zupo, Luisa Lampignano, Caterina Bonfiglio, Gianluigi Giannelli, Alberto R Osella and Vincenzo Triggiani

Pre-Chemistry Concepts and Medical Therapy among the Ancient Physicians through the Pre-Socratic Philosophers

Volume:20
Luigi Santacroce*, Lucrezia Bottalico, Kastriot Haxhirexha, Skender Topi and Ioannis Alexandros Charitos

Medicine and healing in the pre-Socratic thought. A brief analysis of magics and rationalism in ancient herbal therapy.

Volume:20
Luigi Santacroce*, Skender Topi, Kastriot Haxhirexha, Shkelqim Hidri, Ioannis Alexandros Charitos and Lucrezia Bottalico

Characteristics of Patients with Hypopituitarism having Onset Symptoms of Pseudo-Intestinal Obstruction: A Case Report

Volume:20
Ning Yuan*, Sanbao Chai, Jianbin Sun, Yufang Liu, Sixu Xin and Xiaomei Zhang

Bibliometrics and Visualization of the Mechanisms of Parkinson's Diseases Based on Animal Models

Volume:20
Yan-Qiu Wang , Yi-Bing Chen, Dong Xu and Yuan-Lu Cui*

Lead Anti-obesity Compounds from Nature

Volume:20
Vinesh Dahiya, Neeru Vasudeva*, Sunil Sharma, Ashok Kumar and David Rowley

Focus on Receptors for Coronaviruses with Special Reference to Angiotensin- converting Enzyme 2 as a Potential Drug Target - A Perspective

Volume:20
Thea Magrone, Manrico Magrone and Emilio Jirillo*

Modulation of Small Artery Function by Insulin in Young Women: Role of Adiposity

Volume:20
Moulinath Banerjee*, Linda Shaw, Valentyn Charlton-Menys, Phillip Pemberton, Rayaz Ahmed Malik, John Kennedy Cruickshank and Clare Elizabeth Austin

Understanding the Pathogenesis, Therapeutic Targets/Drug Action and Pharmacogenetics of Type 2 Diabetes: Is there a Future for Personalised Medicine?

Volume:20
Godwill Azeh Engwa, Friday Nwalo Nweke, Gilbert Nfor Karngong, Celestine Azubuike Afiukwa and Kingsley Ekene Nwagu

Peripheral Immunosenescence and Central Neuroinflammation: A Dangerous Liaison. A Dietary Approach

Volume:20
Thea Magrone*, Manrico Magrone, Matteo Antonio Russo and Emilio Jirillo

Exercise and Stevia Rebaudiana (R) Extracts Attenuate Diabetic Cardiomyopathy in Type 2 Diabetic Rats: Possible Underlying Mechanisms

Volume:20
Abdelaziz M. Hussein*, Elsayed A. Eid, Ismaeel Bin-Jalia, Medhat Taha and Lashin S. Lashin

Pathogenic Mechanisms and Therapeutic Implication in Nickel-induced Cell Damage

Volume:20
Ahmad Salimi*, Zhaleh Jamali, Saman Atashbar, Saleh Khezri, Amir Mohammad Ghorbanpour and Nahid Etefaghi

Vitamin D Levels Correlate with Metabolic Syndrome Criteria in Algerian Patients: The Ex-vivo Immunomodulatory Effect of α, 25 Dihydroxyvitamin D3

Volume:20
Meroua Bouchemal, Djennat Hakem, Malha Azzouz, Chafia Touil-Boukoffa and Dalila Mezioug*

Red Grape Polyphenol Oral Administration Improves Immune Response in Women Affected by Nickel-Mediated Allergic Contact Dermatitis

Volume:20
Thea Magrone*, Emilio Jirillo, Manrico Magrone, Matteo A. Russo, Paolo Romita , Francesco Massari and Caterina Foti

Association of Interleukin-1 and Inteleukin-1 Receptor Antagonist Gene Polymorphisms with Multiple Sclerosis in Azeri Population of Iran

Volume:20
Mohammad Asgharzadeh, Zahra Ashrafi Jigheh, Hossein Samadi Kafil, Mehdi Farhoudi, Daryoush Savadi Oskouei, Fatemeh Khaki-Khatibi, Manouchehr Fadaee , Ali Vegari, Vahid Asgharzadeh, Nima Najafi-Ghalelou, Behroz Mahdavi Poor and Jalil Rashedi*

Dyspnea and Cough: A Rare Report of the Kimura Disease

Volume:20
Mehran Ebrahimi, Ali Mohebbi, Ali Rabbani, Azin Ghamari, Maryam Nasri and Masoomeh Saberian*

Nickel Allergy of the Skin and Beyond

Volume:20
Malena Gergovska, Razvigor Darlenski* and Jana Kazandjieva

Nickel Allergy: Epidemiology, Pathomechanism, Clinical Patterns, Treatment, and Prevention Programs

Volume:20
Marta Tramontana, Leonardo Bianchi, Katharina Hansel, Daniela Agostinelli and Luca Stingeni*

Exploring the Protective Effect of ShenQi Compound on Skeletal Muscle in Diabetic Macrovasculopathy Mice

Volume:20
Yuhong Duan , Hong Gao, Hongxia Su, Aixia Liu, Ya Liu, Haipo Yuan and Chunguang Xie*

Prevalence of Nonalcoholic Fatty Liver Disease in Familial Mediterranean Fever

Volume:20
Turker Tasliyurt, Erkan Gokce, Safak Sahin*, Asiye Baris Aslan, Ayse Kevser Demir, Suheyla Uzun and Faruk Kutluturk

Time-Dependent Effects in Chronic Urticaria: A Time-Series Perspective of Omalizumab Treatment

Volume:20
Anna Tagka, George I. Lambrou*, Michael Makris, Evangelia Nakou, Electra Nicolaidou , Argyro Chatziioannou and Alexandra Katsarou

Can Triggering Receptors Expressed on Myeloid Cells be used for Diagnosis of Salmonella Typhi Infection?

Volume:20
Maysaa El Sayed Zaki*, Sally Abed, Mohamed Elegezy, Muhammad Daisy, Nashwa Yousef Ebrahim Elkhouly, Ehab M. Fahmy and Nesreen Mostafa Kamel

Yokukansan, a Japanese Herbal Medicine, suppresses Substance Pinduced Production of Interleukin-6 and Interleukin-8 by Human U373 MG Glioblastoma Astrocytoma Cells

Volume:20
Keisuke Yamaguchi, Sho Yamazaki, Seiichiro Kumakura, Akimasa Someya, Masako Iseki, Eiichi Inada and Isao Nagaoka*

Quality of Life in Individuals with Diabetic Foot Syndrome

Volume:20
Emmanuel Navarro-Flores and Omar Cauli*

Chronic Tobacco Exposure by Smoking Develops Insulin Resistance

Volume:20
Suchismita Mukharjee, Sarbashri Bank and Smarajit Maiti*

PCSK9 Inhibitors: From Nature’s Lessons to Clinical Utility

Volume:20
Frederick J. Raal*, Robert Chilton, Naresh Ranjith, Virendra Rambiritch, Rory F. Leisegang, Iftikhar O. Ebrahim, Alet van Tonder, Nelusha Shunmoogam, Célia Bouharati, Moji G. Musa, Sumanth Karamchand, Poobalan Naidoo and D. J. Blom

The Role of Chemokines in Alzheimer's Disease

Volume:20
Adrian Jorda, Juan Campos-Campos, Antonio Iradi, Martin Aldasoro, Constanza Aldasoro, Jose M. Vila and Soraya L. Valles*

Short-term Effect of Hypergastrinemia Following Esomeprazole Treatment On Well-Controlled Type 2 Diabetes Mellitus: A Prospective Study

Volume:20
Yusuf Bozkuş*, Umut Mousa, Özlem Turhan İyidir, Nazlı Kırnap, Canan Çiçek Demir, Aslı Nar and Neslihan Başçıl Tütüncü

Italian Association of Clinical Endocrinologists (AME) and Italian AACE Chapter Position Statement for Clinical Practice: Acromegaly - Part 1: Diagnostic and Clinical Issues

Volume:20
Renato Cozzi, Maria Rosaria Ambrosio, Roberto Attanasio*, Alessandro Bozzao, Laura De Marinis, Ernesto De Menis, Edoardo Guastamacchia, Andrea Lania, Giovanni Lasio, Francesco Logoluso, Pietro Maffei, Maurizio Poggi, Vincenzo Toscano, Michele Zini, Philippe Chanson and Laurence Katznelson

Phytotherapy of Hypertension: An Updated Overview

Volume:20
Mohammed Ajebli and Mohamed Eddouks*