Letters in Drug Design & Discovery

Editor-in-Chief

K. Kuca
University of Hradec Kralove
Hradec Kralove
(Czech Republic)

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Articles Ahead of Print

Comparative proteome analysis of Mycobacterium tuberculosis strains - H37Ra, H37Rv, CCDC5180, and CAS/NITR204: A step forward to identify novel drug target.

Volume:17
Shradheya R.R. Gupta, Ekta Gupta, Avnam Ohri, Sandeep Kumar Shrivastava, Sunita Kachhwaha, Vinay Sharma, Rupesh Kumar Mishra and Ravi Ranjan Kumar Niraj*

Effect of Cabergoline on Cognitive Impairments in Transgenic Drosophila Model of Parkinson’s Disease

Volume:17
Yasir Hasan Siddique*, Rahul, Mantasha Idrisi and M. Shahid

Novel 2-(5-Aryl)thiophen-2-yl)benzimidazoles; Design, Synthesis and In vitro Evaluation Against Cercarial Phase of Schistosoma mansoni

Volume:17
Serry A. El Bialy, Basem Mansour*, Waleed A. Bayoumi, Amira Taman and Hassan M. Eissaa

Novel Benzimidazole Derivatives: Cytotoxic and Apoptotic Properties on Lung Cancer Cell Line

Volume:17
Leyla Yurttas*, Gulsen Akalin Ciftci, Mehmet Onur Aksoy and Seref Demirayak

Anti-inflammatory Augmentation Therapy in Obsessive Compulsive Disorder: A Review

Volume:17
Hanie Ghasemi, Homa Nomani, Amirhossein Sahebkar* and Amir Hooshang Mohammadpour

In Silico Design of a Novel Multi-Epitope Peptide Vaccine Against Hepatocellular Carcinoma

Volume:17
Fatemeh Motamedi Dehbarez, Navid Nezafat and Shirin Mahmoodi*

Discovery of New N-hydrazinecarbothioamide Indazole Hybrids: As Potential Radical (ABTS and DPPH) Scavengers

Volume:17
Rafaila Rafique, Arshia, Kanwal, Khalid Mohammed Khan*, Sridevi Chigurupati, Uzma Salar, Muhammad Taha and Shahnaz Perveen

Molecular insights into the interaction of ursolic acid and cucurbitacin from colocynth with therapeutic targets of Mycobacterium tuberculosis

Volume:17
Muhammad Ajmal Ali, Mohammad Abul Farah*, Joongku Lee, Khalid M. Al-Anazi and Fahad Al-Hemaid

Natural Sesquiterpene Lactones in the Prevention and Treatment of Inflammatory Disorders and cancer: A Systematic Study of this Emerging Therapeutic Approach based on Chemical and Pharmacological Aspect

Volume:17
Sudip Kumar Mandal, Utsab Debnath, Amresh Kumar, Sabu Thomas, Subhash Chandra Mandal, Manabendra Dutta Choudhury and Partha Palit*

Development of Phthalimide-Donepezil Hybrids as Potent Multitarget- Directed Ligands for the Treatment of Alzheimer’s Disease

Volume:17
Lintao Yu, Jian Shi, Xinfeng Cheng, Keren Wang, Shuang Liu, Wenmin Liu and Zhipei Sang*

Synthesis and Biological Evaluation of Benzodioxol Derivatives as Cyclooxygenase Inhibitors

Volume:17
Nidal Jaradat*, Mohammed Hawash and Murad N. Abualhasan

Oleanolic Acid Derived from Plants: Synthesis and Pharmacological Properties of A-ring Modified Derivatives

Volume:17
Tingjuan Wu, Xu Yao, Guan Wang, Xiaohe Liu, Hongfei Chen, Zehua Yang and Xing Zheng*

Molecular Docking of 4-ehoxychalcones on Oxidoreductase/Pirin Inhibitors and Cytotoxic Evaluation on Breast/Skin Cancer Cell Lines

Volume:17
Kishori Ramachandra Harshitha, Balladka Kunhanna Sarojini*, Badiadka Narayana, Anupam Glorious Lobo and Bhuvanesh Sukhlal Kalal

In Vitro Characteristics of Glioma Cells Targeting by OX26-modified Liposomal Cisplatin

Volume:17
Maryam Sadat Ashrafzadeh, Amir Heydarinasab*, Azim Akbarzadeh and Mehdi Ardjmand

Fingerprint-based 2D-QSAR Models for Predicting Bcl-2 Inhibitors Affinity

Volume:17
Said Byadi, Mouhi Eddine Hachim, Karima Sadik, Črtomir Podlipnik and Aziz Aboulmouhajir*

Studies on the IC50 of Metabolically Stable 1-(3,3-diphenylpropyl)- piperidinyl Amides and Ureas as Human CCR5 Receptor Antagonists Based on QSAR

Volume:17
Yutao Zhao, Xiaoqian Liu, Jing Ouyang, Yan Wang, Dongdong Tian, Shanyu Xu and Hongzong Si*

Indole Curcumin Reverses Multidrug Resistance by Reducing the Expression of ABCB1 and COX2 in Induced Multidrug Resistant Human Lung Cancer Cells

Volume:17
Sankar Pajaniradje , Kumaravel Mohankumar, Rakesh Radhakrishnan , Shamim Akhtar Sufi, Srividya Subramanian , Parthiban Anaikutti, Surya Prakash Rao H and Rukkumani Rajagopalan *

Experimental Study of Therapeutic Efficacy of the Topical Preparation «Kourochitin» in Skin Allergy

Volume:17
Anna Klimovich*, Olga Styshova, Alexander Popov, Tatiana Moskvina , Valentin Stonik, Alexander Tsybulsky and Dmitry Derunov

Binding Mode Prediction and Identification of New Lead Compounds from Natural Products as 3-OST Enzyme Inhibitors

Volume:17
Rui Sousa, NS Hari Narayana Moorthy*, Natercia Bras, Pedro Fernandes and Maria Ramos

A Review on Robust Computational Approaches Based Identification and Authentication of Herbal Raw Drugs

Volume:17
Preet Amol Singh, Neha Bajwa, Subh Naman and Ashish Baldi*

Synthesis, Docking, in silico ADMET and Pharmacological Evaluation of Some N-acetyl Pyrazole and Quinoline Conjugates

Volume:17
Nargisbano Peerzade, Shravan Jadhav*, Raghunath Bhosale, Amol Kulkarni and Bhushan Varape

The 2019 Novel Coronavirus (COVID-19) Outbreak in China and World: A New Lesson for Public Health System

Volume:17
Kamil Kuca*

JAK/STAT3 Pathway in Human Intestinal Epithelial Cells During Trefoil Factor 3(TFF3) Mediated Cell Migration

Volume:17
Mengmeng Zhuang, Juan Le, Bo Zhu, Wenwen Zhang, Hao Yan, Pan zhang, Ting Wang and Yong Sun*

Effect of Steroidal Hormone Pregnenolone on Proliferation and Differentiation of MC3T3-E1 Osteoblast like Cells

Volume:17
Serene A. Badran, Atia-tul-Wahab, Sharmeen Fayyaz, Bushra Taj Muhammad and M. Iqbal Choudhary*

Anticholinesterase Activity of Cinnamic Acids Derivatives: In Vitro, In Vivo Biological Evaluation, and Docking Study

Volume:17
Shahrzad Ghafary, Hamid Nadri, Mohammad Mahdavi, Alireza Moradi, Tahmineh Akbarzadeh, Mohammad Sharifzadeh, Najmeh Edraki, Farshad Homayouni Moghadam and Mohsen Amini*

Synthesis, Molecular Docking and α-Glucosidase Inhibitory Activity Study of 2,4,6-triaryl pyrimidine Derivatives

Volume:17
Mohammed Hussen Bule , Roghaieh Esfandyari, Tadesse Bekele Tafesse, Mohsen Amini*, Mohammad Ali Faramarzi and Mohammad Abdollahi

Searching for Potential HDAC2 Inhibitors: Structure-activity Relationship Studies on Indole-based Hydroxamic Acids as an Anticancer Agent

Volume:17
Ekta Shirbhate, Divya, Preeti Patel, Vijay K. Patel, Ravichandran Veerasamy, Prabodh C. Sharma and Harish Rajak*

Synthesis, Biological Evaluation and Molecular Modeling Studies of Novel C (7) Modified Analogues of Chrysin

Volume:16
P. Ramesh, V. Srinivasa Rao, P. Muralidhar Reddy*, K. Suresh Babu and M. Srinivasa Rao

Synthesis and Evaluation of α-Asaronol Esters with LDH and GABAA Receptor Modulation as Anticonvulsant Agents

Volume:16
Yajun Bai, Bin Li, Jing Xie, Xufei Chen, Shu Cheng, Yujun Bai, Ying Sun, Fanggang Qin, Jing Liang, Yanrui Ding and Xiaohui Zheng*

Enhancement Effect of Zn-Arsenazo III Complex for G-quadruplex DNA Stability of Proto-oncogene Promoter Telomeres

Volume:16
Liyuan Zou, Hongbo Li*, Mingbin Liu, Weihua Zhao and Suqin Wang*

Discovery of 2-aminopyridine Derivatives with Antichagasic and Antileishmanial Activity Using Phenotypic Assays

Volume:16
Daiane Yukie Tezuka, Sergio de Albuquerque, Carlos Alberto Montanari and Andrei Leitão*

Design and Synthesis of 4(1H)-quinolone Derivatives as Autophagy Inducing Agents by Targeting ATG5 Protein

Volume:16
Yifan Jia, Difei Yu, Qiuhua Huang, Xiaodong Zhang, Liqin Qiu, Rihui Cao*, Runlei Du and Wenbin Liu

Understanding the Binding Mechanism of Anti-antagonist (AZD3293) Against BACE-1: Molecular Insights into Alzheimer’s Drug Discovery

Volume:16
Sphelele Sosibo, Daniel Gyamfi Amoako, Anou Moise Somboro, Darren Delai Sun, Jane Catherine Ngila and Hezekiel Kumalo*

Development of Novel Glitazones as Antidiabetic Agents: Molecular Design, Synthesis, Evaluation of Glucose Uptake Activity and SAR Studies

Volume:16
G. S Mahendra, P Prabitha , Subhankar P. Mandal, S Yuvaraj , Pranesh Guddur and B. R. Prashantha Kumar*

Facile Synthesis of 6-Phenyl-6h-chromeno [4, 3-b] Quinoline Derivatives using NaHSO4@SiO2 Re-usable Catalyst and Their Antibacterial Activity Study Correlated by Molecular Docking Studies

Volume:16
Kancharla Sumana, Jyothi Prashanth , Koya Prabhakara Rao*, Madala Subramanyam, Vejendla Anuradha and Mandava Venkata Basaveswara Rao