Letters in Drug Design & Discovery

Editor-in-Chief
K. Kuca
University of Hradec Kralove
Hradec Kralove
Czech Republic

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Graphical Abstracts open Access plus

Volume:9   Issue: 1
Pp: i-v

DOI: 10.2174/157018012798192964

Editorial open Access plus

Volume:9   Issue: 1
Pp: 1-1
Atta-ur-Rahman
DOI: 10.2174/157018012798192937

Design and Synthesis of 3-Arylisoxazoline-5-Carboxamide and 3-Arylisoxazoline-5-Acetamide Libraries as Potential Factor Xa Inhibitors open Access plus

Volume:9   Issue: 1
Pp: 2-7
John F. Quinn, Brian T. Gregg, Douglas B. Kitchen, Robert M. Lewis, Dana A. Razzano, Lauren E. Kayser, Levon J. Schilling and Kathryn C. Golden
DOI: 10.2174/157018012798193035

Antioxidant Activity of Resveratrol Analogs open Access plus

Volume:9   Issue: 1
Pp: 8-11
Natalia Oliveira Calil, Gustavo Senra Goncalves de Carvalho, Danielle Cristina Zimmermann Franco, Adilson David da Silva and Nadia Rezende Barbosa Raposo
DOI: 10.2174/157018012798192928

Semi-Automatic Synthesis of Distamycin Analogues and their DNA Binding Properties open Access plus

Volume:9   Issue: 1
Pp: 12-16
Danuta Drozdowska and Jakub Szerszenowicz
DOI: 10.2174/157018012798192919

Ligand and Structure-Based Pharmacophore Modeling for the Discovery of Potential Human HNMT Inhibitors open Access plus

Volume:9   Issue: 1
Pp: 17-29
Pavadai Elumalai, Hsuan-Liang Liu, Zheng-Li Zhou, Jian-Hua Zhao, Wilson Chen, Chih-Kuang Chuang, Wei-Bor Tsai and Yih Ho
DOI: 10.2174/157018012798192955

Synthesis and Anti-Paracoccidioides Activity of Calix[n]arenes open Access plus

Volume:9   Issue: 1
Pp: 30-36
Marcilene Coimbra de Oliveira, Fabiano Souza Reis, Angelo de Fatima, Thais Furtado Ferreira Magalhaes, Danielle Leticia da Silva, Raphael Rodrigues Porto, Giselle Almeida Watanabe, Cleide Viviane Buzanello Martins, Daniel Leite da Silva, Ana Lucia Tasca Gois Ruiz, Sergio Antonio Fernandes, Joao Ernesto de Carvalho and Maria Aparecida de Resende-Stoianoff
DOI: 10.2174/157018012798192991

Preliminary Evaluation of Anticonvulsant Activity of Some Aminoalkanol and Amino Acid Cinnamic Acid Derivatives open Access plus

Volume:9   Issue: 1
Pp: 37-43
Agnieszka Gunia, Anna M. Waszkielewicz, Marek Cegla and Henryk Marona
DOI: 10.2174/157018012798192982

Discovery of 5,6-Dihydro-indolo[1,2-a]quinoxaline Derivatives as New HIV-1 Inhibitors In Vitro open Access plus

Volume:9   Issue: 1
Pp: 44-47
Ling-Ling Fan, Ning Huang, Rui-Ge Yang, Shu-Zhen He, Liu-Meng Yang, Hui Xu and Yong-Tang Zheng
DOI: 10.2174/157018012798193026

Evaluation of the Radioprotective Potential of the Polyphenol Norbadione A open Access plus

Volume:9   Issue: 1
Pp: 48-53
Antoine Le Roux, Elodie Josset, Sami Benzina, Brice Nadal, Marine Desage-El Murr, Benoit Heurtaux, Frederic Taran, Jean-Marc Denis, Thierry Le Gall, Stephane Meunier and Pierre Bischoff
DOI: 10.2174/157018012798192900

Lobeline Docking on AChBP and Nicotinic Receptors: Discriminating Importance of the Pocket Geometry and of the Ligand Configuration open Access plus

Volume:9   Issue: 1
Pp: 54-62
Claire Colas, Xavier Brotel, Nathalie Duclert-Savatier, Michael Nilges, Delphine Joseph and Therese E. Malliavin
DOI: 10.2174/157018012798193017

Synthesis and Biological Evaluation of Some Novel Thiazolylhydrazinomethylideneferrocenes as Antimicrobial Agents open Access plus

Volume:9   Issue: 1
Pp: 63-68
Navneet Chandak, Pawan Kumar, Chetan Sharma, Kamal R. Aneja and Pawan K. Sharma
DOI: 10.2174/157018012798192973

Synthesis, Biochemical Evaluation and Rationalisation of a Series of (3-O-Sulfonate) Derivatives of Estrone (E1) as Probes of the Active Site of Type 3 of the 17β-Hydroxysteroid Dehydrogenase (17β-HSD) Family of Enzymes open Access plus

Volume:9   Issue: 1
Pp: 69-76
Mohsen Akbarzadeh, Moniola S. Olusanjo and Sabbir Ahmed
DOI: 10.2174/157018012798193044

Pramipexole Tachyphylaxis and its Management in Bipolar Depression open Access plus

Volume:9   Issue: 1
Pp: 77-77
Verinder Sharma
DOI: 10.2174/157018012798193008

Design, Synthesis and Biological Evaluation of Scutellarein Derivatives as Potential Anti-Alzheimers Disease Candidates Based on Metabolic Mechanism open Access plus

Volume:9   Issue: 1
Pp: 78-83
Shu-Lin Song, Nian-Guang Li, Yu-Ping Tang, Zhen-Jiang Wang, Li-Hua Qian, Hao Tang and Jin-Ao Duan
DOI: 10.2174/157018012798192946

Small Molecule Tyrosine Kinase Inhibitors: The New Dawn for Cancer Therapy open Access plus

Volume:9   Issue: 1
Pp: 84-125
Malleshappa N. Noolvi and Harun M. Patel
DOI: 10.2174/157018012798192892