Letters in Drug Design & Discovery

Editor-in-Chief:

George Perry
University of Texas
San Antonio, TX
USA

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Volume:8   Issue:8
Pp: i-v

DOI: 10.2174/157018011796576042

DNA Polymerase β Specific Inhibitors, a Loliolide Derivative and Pubinernoid A, Isolated from the Brown Algae Laminaria sp.

Volume:8   Issue:8
Pp: 671-677
Yoshiyuki Mizushina, Toshifumi Takeuchi, Isoko Kuriyama, Yoshihiro Takahashi, So Maezawa, Takuro Matsumoto, Osamu Koiwai, Fumio Sugawara and Hiromi Yoshida
DOI: 10.2174/157018011796576024

Characterization of Carbonic Anhydrase Isozyme Specific Inhibition by Sulfamated 2-Ethylestra Compounds

Volume:8   Issue:8
Pp: 678-684
Katherine H. Sippel, Andre Stander, Chingkuang Tu, Balasubramanian Venkatakrishnan, Arthur H. Robbins, Mavis Agbandje-McKenna, Fourie Joubert, Annie M. Joubert and Robert McKenna
DOI: 10.2174/157018011796576105

Prevention of VP-16 Resistance by a Disiloxane, SILA409: Effects of SILA409 on the Expression of GRP78 in NCI-H446 Human Small Cell Lung Cancer Cells

Volume:8   Issue:8
Pp: 691-697
Encheng Li, Jinhui Zhang, Jiarui Wang, Fei Gao, Zhonghai Yang, Qiang Meng, Qianqian Zhang, Na Li, Ming Huang, Gabriella Spengler, Joseph Molnar and Qi Wang
DOI: 10.2174/157018011796575971

Synthesis and Anti – Tumour Activity of Novel Camptothecin – Bile Acid Analogues

Volume:8   Issue:8
Pp: 698-703
Q.-Y. Li, Y. Gao, W. Qiu, Y.-G. Zu, L. Su, W.-N. He and X.-Q. Deng
DOI: 10.2174/157018011796576006

Design, Synthesis and Cytotoxicity of Chalcone Analogs Derived from 2-Phenylimino-3-phenylthiazolidin-4-one

Volume:8   Issue:8
Pp: 704-708
Vijay Satam, Ravi Kumar Bandi, Ajaya Kumar Behera, Bijay Kumar Mishra, Olivia Brockway, Samuel Tzou, Matthias Zeller, Moses Lee and Hari Pati
DOI: 10.2174/157018011796576033

Aryl and Acyclic Unsaturated Derivatives of Thioguanine and 6- Mercaptopurine: Synthesis and Cytotoxic Activity

Volume:8   Issue:8
Pp: 709-716
Tien N. Banh, Nageswara R. Kode and Shashikant Phadtare
DOI: 10.2174/157018011796576088

Synthesis and Preliminary In-Vitro Cytotoxic Activity of Novel Substituted diaryl-imidazo [2,1,b]-benzothiazole Derivatives

Volume:8   Issue:8
Pp: 717-724
Jitender K. Malik, Malleshappa N. Noolvi, Fakkirappa V. Manvi, B.K. Nanjwade, Harun M. Patel, Manjula S. N., Mallikarjuna Rao C. and Ashutosh Barve
DOI: 10.2174/157018011796576015

Nicotinic Acid Benzylidene/Phenyl-Ethylidene Hydrazides: Synthesis, Antimicrobial Evaluation and QSAR Studies

Volume:8   Issue:8
Pp: 733-749
Rakesh Narang, Balasubramanian Narasimhan, Sunil Sharma, Dharmarajan Sriram, Perumal Yogeeswari, Erik De Clercq, Christophe Pannecouque and Jan Balzarini
DOI: 10.2174/157018011796575999

Concise and Facile Synthesis of Novel Pyrano[2,3-d]pyrimidine-7- one/thione Derivatives as In Vitro Antimicrobial and Antitubercular Agents

Volume:8   Issue:8
Pp: 750-757
Prashant T. Mistry, Nimesh R. Kamdar, Dhaval D. Haveliwala and Saurabh K. Patel
DOI: 10.2174/157018011796576060

Synthesis and Antifungal Activities of Some Aryl Naphthofuran Ketoximes

Volume:8   Issue:8
Pp: 758-762
Ahmet Cagri Karaburun, Nalan Gundogdu-Karaburun, Umit Ucucu and Seref Demirayak
DOI: 10.2174/157018011796576097

Facile Synthesis, Antibacterial Activity and Molecular Properties Prediction of Some New 1,3-dihydroimidazol-2-thione Derivatives

Volume:8   Issue:8
Pp: 763-768
Julfikar Ali Junejo, Surajit Kumar Ghosh, Mutahar Shaikh, Prashant Gahtori and Udaya Pratap Singh
DOI: 10.2174/157018011796575980

Synthesis and Anticonvulsant Activity Evaluation of 6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines

Volume:8   Issue:8
Pp: 769-773
Ming-Xia Song, Chun-Bo Zhang, Xian-Qing Deng, Zhi-Gang Sun and Zhe-Shan Quan
DOI: 10.2174/157018011796575962

Synthesis, Neurotoxicity and Anticonvulsant Study of Some Benzothiazole Analogs

Volume:8   Issue:8
Pp: 774-777
Kalyan K. Sethi, Saurabh M. Verma, Naru Prasanthi and Mathrusri M. Annapurna
DOI: 10.2174/157018011796575953