Letters in Drug Design & Discovery

Editor-in-Chief
K. Kuca
University of Hradec Kralove
Hradec Kralove
Czech Republic

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Evaluation of the Ability of an Organic Derivative of Ruthenium(II) to Reinforce the Cytotoxicity of Fast Neutron Against Malignant Cells in Culture open Access plus

Volume:5   Issue: 1
Pp: 1-6
P. Bischoff, L. Leyva, F. Malek, S. Benzina, J. M. Denis, J. Gueulette, P. Dufour, C. Gaiddon, J. P. Loeffler, C. Sirlin and M. Pfeffer
DOI: 10.2174/157018008783406714

CoMFA Study, Syntheses, Antitubercular and Anticancer Activity of Some Novel 1,4-Dihydropyridines open Access plus

Volume:5   Issue: 1
Pp: 7-14
B.R. Prashantha Kumar, S. Yuvaraj, Anil Srivastava, Vanitha Chaturvedi, Y. K. Manju, B. Suresh and M. J. Nanjan
DOI: 10.2174/157018008783406688

Synthesis, In Vitro Evaluations and Structure-Activity Assessment of Pyrrole Hydrazones as Potential Tuberculostatics open Access plus

Volume:5   Issue: 1
Pp: 15-24
A. Bijev
DOI: 10.2174/157018008783406651

Synthesis and Evaluation of N-Aryl 2-Aminothiazole-4-Carboxamide Derivatives for Activity Against TB open Access plus

Volume:5   Issue: 1
Pp: 25-28
R. M. Riggs, R. K. Jennings, E. R. Derstine, T. M. Nguyen, T. Trinh and J. M. Riordan
DOI: 10.2174/157018008783406615

Immunomodulation and Anti-Inflammatory Effects of Macrolides: Old Drugs with Fascinating New Perspectives open Access plus

Volume:5   Issue: 1
Pp: 29-35
I. Starakis
DOI: 10.2174/157018008783406642

Selective Inhibition of Neuronal Nitric Oxide Synthase by L-Arginine Derivatives open Access plus

Volume:5   Issue: 1
Pp: 36-38
Anna Capasso, Carmela Saturnino and Mariafrancesca Buonerba
DOI: 10.2174/157018008783406660

Design and Synthesis of 2-Azetidinone Cholesterol Absorption Inhibitors open Access plus

Volume:5   Issue: 1
Pp: 39-42
Huibin Zhang, Yubin Wang, Rui Zhao, Wenlong Huang, Yunman Li and Jinpei Zhou
DOI: 10.2174/157018008783406741

Solution Phase Synthesis of a 3,5,7-Substituted Indolin-2-one Library as Potential CDK2 Inhibitor Isosteres open Access plus

Volume:5   Issue: 1
Pp: 43-47
Dmytro O. Tymoshenko, Brian T. Gregg, Matthew J. Hirsch and Jennifer L. Butcher
DOI: 10.2174/157018008783406633

Inhibition of 17β -Hydroxysteroid Dehydrogenase (17β -HSD) by Imidazole-Based Compounds open Access plus

Volume:5   Issue: 1
Pp: 48-51
Sabbir Ahmed, Moniola S. Olusanjo, Imran Shahid and Caroline P. Owen
DOI: 10.2174/157018008783406705

Synthesis and Chymotrypsin Inhibitory Activity of Substituted Oxazolones open Access plus

Volume:5   Issue: 1
Pp: 52-56
Khalid Mohammed Khan, Uzma Rasool Mughal, Muhammad Arif Lodhi and Muhammad Iqbal Choudhary
DOI: 10.2174/157018008783406624

Classical and Fragment-Based Hologram Structure-Activity Relationships for a Series of Analgesic Cyclic Imides open Access plus

Volume:5   Issue: 1
Pp: 57-64
A. D. Andricopulo, D. M. Borchhardt and M. S. Castilho
DOI: 10.2174/157018008783406723

Central Administration of L-Ser-L-His and L-Ile-L-His Induced Sedative Effects Under an Acute Stressful Condition in Chicks open Access plus

Volume:5   Issue: 1
Pp: 65-68
Mitsuhiro Furuse, Yousuke Tsuneyoshi, Shozo Tomonaga, Haruka Yamane, Koji Morishita and D. Michael Denbow
DOI: 10.2174/157018008783406679

Flavylium Salts as Precursors of Biologically Active Chalcones open Access plus

Volume:5   Issue: 1
Pp: 69-73
Karl A. Werbovetz, Tesmol G. George, Julian Richard, Todd Barszcz and Jeffrey Capers
DOI: 10.2174/157018008783406697

Antifungal Activity of Goniothalamin Enantiomers open Access plus

Volume:5   Issue: 1
Pp: 74-78
Angelo de Fatima, Cleide Viviane Buzanello Martins, Maria Aparecida de Resende, Thais Furtado Ferreira Magalhaes, Bruno Henrique Santiago Lima, Gisele Almeida Watanabe, Ana Lucia Tasca Gois Ruiz, Joao Ernesto de Carvalho and Ronaldo Aloise Pilli
DOI: 10.2174/157018008783406732