Letters in Drug Design & Discovery

Editor-in-Chief:

George Perry
University of Texas
San Antonio, TX
USA

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MDR Reversal by Deprenylated Tetracyclic and Hexacyclic Analogues of N-Acetylardeemin: Confirmation of the Ardeemin Pharmacophore

Volume:3   Issue:6
Pp: 369-377
Carmen Avendano, Esmeralda Caballero, Cristina Mendez-Vidal, Ana R. de Quesada and J. Carlos Menendez
DOI: 10.2174/157018006777805558

Coenzyme Q10 and Neurological Diseases: An Update

Volume:3   Issue:6
Pp: 378-382
Michelangelo Mancuso, Anna Choub, Massimiliano Filosto, Lucia Petrozzi, Gianfranco Cafforio, Gabriele Siciliano and Luigi Murri
DOI: 10.2174/157018006777805495

Lead Optimisation: Improving the Affinity of the Antiretrovirals Nelfinavir and Amprenavir for HIV-1 Protease

Volume:3   Issue:6
Pp: 383-389
P. A. Fernandes, M.L. A.C. Araujo, A. J.M. Barbosa, C. N. Alves, Z. Q. Ferreira, C. R.-N. Gonzalez, C.F. R.A. C. Lima, S. I.E. Loureiro, J. M.T. Magalhaes, F. C. Maia, S. A. Moura, E.M. M. Peredo, M.A. S. Perez, T.A. Q. Rodrigues, A.M. Pessoa, C.A. M. da Silva, J.P. A. da Silva and M. J. Ramos
DOI: 10.2174/157018006777805576

Utilization of Ribozymes as Antiviral Agents

Volume:3   Issue:6
Pp: 390-404
M. L. Benitez-Hess and L. M. Alvarez-Salas
DOI: 10.2174/157018006777805521

High-Throughput Lipophilicity Screening of Opioid-Like Analgesics: Validation of Computational Methods by Means of RP-HPLC Analysis

Volume:3   Issue:6
Pp: 413-418
O. Azzolina, S. Collina, D. Rossi, A. Carnevale Baraglia, S. Alcaro and A. Artese
DOI: 10.2174/157018006777805530

Antitubercular Properties of Substituted Hydroxycyclohexadienones

Volume:3   Issue:6
Pp: 419-423
Manish Shah, Geoffrey Wells, Tracey D. Bradshaw, Charles A. Laughton, Malcolm F.G. Stevens and Andrew D. Westwell
DOI: 10.2174/157018006777805486

Synthesis and In Vitro Anti-Tubercular Activity of a Series of N- (Disubstitutedbenzoyl)Isoniazid Derivatives

Volume:3   Issue:6
Pp: 424-428
Ivan Neves Junior, Maria C.S. Lourenco, Guilherme de B.P. de Miranda, Thatyana R.A. Vasconcelos, Karla C. Pais, Jose dos P. de A. Junior, M. S.V. Wardell, James L. Wardell and V. N. de Souza
DOI: 10.2174/157018006777805549

Replacement of Cyclosporin A from its Binding to Hepatocyte Plasma Membrane by Silymarin Flavonoids

Volume:3   Issue:6
Pp: 429-435
Vladimira Moulisova, Jiri Sebestian, Olga Jedlickova, Alexandr Jegorov and Stepanka B. Sebestianova
DOI: 10.2174/157018006777805567