Letters in Drug Design & Discovery

Editor-in-Chief
K. Kuca
University of Hradec Kralove
Hradec Kralove
Czech Republic

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Evaluation of the Effects of a New Drug on Brain Leukocyte Infiltration in an Experimental Model of Autoimmune Encephalomyelitis

Volume:3   Issue: 3
Pp: 138-148
A. Mangas, R. Covenas, D. Bodet, M. P. Dabadie, G. Glaize and M. Geffard
DOI: 10.2174/157018006776286943

Pt(II) vs Pd(II) Polyamine Complexes as New Anticancer Drugs: A Structure- Activity Study

Volume:3   Issue: 3
Pp: 149-151
S. M. Fiuza, A. M. Amado, Paulo J. Oliveira, Vilma A. Sardao, L. A.E.B. de Carvalho and M. P.M. Marques
DOI: 10.2174/157018006776286989

Synthesis and Evaluation of Calpain Inhibitors Carrying Muscle Cell Targeting Groups

Volume:3   Issue: 3
Pp: 152-158
P. Weyermann, H. Herzner, C. Lescop, H. Siendt, R. Bolliger, M. Hennebohle, C. Rummey, A. Briguet, I. Courdier-Fruh, M. Erb, M. Foster, J.P. Magyar, A. von Sprecher and T. Meier
DOI: 10.2174/157018006776286916

Regulation of MMP/TIMP Balance as Therapeutic Target in Pulmonary Diseases

Volume:3   Issue: 3
Pp: 159-171
Corinne A.E. Martin-Chouly, Stephanie Guillot, Stephane Jouneau, Sylvie Caulet-Maugendre, Laurent Vernhet, Vincent Lagente and Philippe Delaval
DOI: 10.2174/157018006776287005

HIF-1α as a Target for Drug Design in Ischemic Injury: Effect of Cobalt Treatment on Mitochondrial DNA Damage in Cells Exposed to H2O2

Volume:3   Issue: 3
Pp: 172-174
Yasutomo Nomura, Hiroyuki Fujiwara, Kohei Ito, Hirobumi Fuchigami, Michihiko Sato, Eiji Takahashi, Yasukazu Hozumi, Kaoru Goto, Zhonggang Feng and Takao Nakamura
DOI: 10.2174/157018006776286952

5-Hydroxy-6-Quinaldic Acid as a Novel Molecular Scaffold for HIV-1 Integrase Inhibitors

Volume:3   Issue: 3
Pp: 175-178
J. Polanski, H. Niedbala, R. Musiol, B. Podeszwa, D. Tabak, A. Palka, A. Mencel, J. Finster, J.- F. Mouscadet and M. L. Bret
DOI: 10.2174/157018006776286934

Synthesis and Evaluation of Hypolipidemic Properties of some Novel Derivatives of Thieno Oxazine and 5-Hydroxyindole-2-Carboxylic Acid

Volume:3   Issue: 3
Pp: 179-182
Sankar Mohan, K. A. Reddy, Javed Iqbal, Debnath Bhuniya and Saibal K. Das
DOI: 10.2174/157018006776287014

Synthesis and Biological Activity of 4-Amino-1-Methyl-5-Imidazolecarboxylic Acid Derivatives

Volume:3   Issue: 3
Pp: 192-199
A. Regiec, H. Mastalarz, R. Miedzybrodzki, K. Smietanska and R. Jasztold-Howorko
DOI: 10.2174/157018006776286961

Increasing the Odds of Drug Hit Identification by Screening Against Receptor Homologs?

Volume:3   Issue: 3
Pp: 200-204
Z. L. Ji, Z. R. Li, J. F. Wang, C. Z. Cai, L. Y. Han, C. J. Zheng and Y. Z. Chen
DOI: 10.2174/157018006776286970

Synthesis and Biological Activity of New 4β-N-Heteroaryl Analogues of Podophyllotoxin

Volume:3   Issue: 3
Pp: 205-209
Ahmed Kamal, B. A. Kumar, M. Arifuddin and Sunanda G. Dastidar
DOI: 10.2174/157018006776286907