Letters in Drug Design & Discovery

Editor-in-Chief:

George Perry
University of Texas
San Antonio, TX
USA

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A 3D-QSAR of N-Substituted 4-Amino3-3-Dialkyl-2 (3H)-Furanone GABAA Receptor Modulators Based on Receptor Surface Analysis open Access plus

Volume:3   Issue:1
Pp: 1-8
Savita Bhutoria, Prasenjit K. Mukherjee, Sandeep Chhabra and Nanda Ghoshal
DOI: 10.2174/157018006775240926

Preliminary Investigation of Structure-Activity Relationship of Cytotoxic Physalins open Access plus

Volume:3   Issue:1
Pp: 9-13
H. I.F. Magalhaes, M. L. Veras, O. D.L. Pessoa, E. R. Silveira, M. O. Moraes, C. Pessoa and L. V. Costa-Lotufo
DOI: 10.2174/157018006775240917

C5,C6-Disubstituted 1H-Indole-2-Carboxamides: Synthesis and Cytotoxic Activity in the Human Non-Small Lung Cancer Cell Line NSCLC-N16-L16 open Access plus

Volume:3   Issue:1
Pp: 14-16
Andrew Tsotinis, Maria Gerasimopoulou, Margarita Vlachou, Dimitri Moreau and Christos Roussakis
DOI: 10.2174/157018006775240980

Computer-Assisted Analysis of the Interactions of Macrocyclic Inhibitors with wild Type and Mutant D168A Hepatitis C Virus NS3 Serine Protease open Access plus

Volume:3   Issue:1
Pp: 17-28
Elaine F.F. da Cunha, Teodorico C. Ramalho, Carlton A. Taft and Ricardo B. de Alencastro
DOI: 10.2174/157018006775240953

Enhancement of Drug Cytotoxicity by Silicon Containing Groups open Access plus

Volume:3   Issue:1
Pp: 29-34
Jose M. Padron, Osvaldo J. Donadel, Leticia G. Leon, Tomas Martin and Victor S. Martin
DOI: 10.2174/157018006775240944

Synthesis and Evaluation of Anthelmintic and Cytotoxic Properties of Bis- 1,3-Azole Analogs of Natural Products open Access plus

Volume:3   Issue:1
Pp: 35-43
D. Sellanes, L. Scarone, G. Mahler, E. Manta, A. Baz, S. Dematteis, J. Saldana, L. Dominguez, P. Wipf and G. Serra
DOI: 10.2174/157018006775240962

Initial Design and Synthesis of Conformationally Restricted and Pharmacophore-Based Scaffold Hopping Analogs of a Ras Pathway Modulator and Evaluation of Their MAPK Inhibitory Activities open Access plus

Volume:3   Issue:1
Pp: 44-48
Sukumar Sakamuri, Quin-Zene Chen, Yingchun Lu, Yen-Fang Keng, Vladimir Khazak, Katrin Illgen, Silke Schabbert, Lutz Weber and Sanjay R. Menon
DOI: 10.2174/157018006775240890

Novel 5-HT7 Ligands as Antidepressants: Automated Synthesis of NSubstituted- N-[1-Methyl-3-(4-Methylpiperidin-1-yl)propyl]-Arylsulfonamides open Access plus

Volume:3   Issue:1
Pp: 49-54
Eric Lattmann, Isidro Merino, Simon Dunn, Bushra Parveen, Pornthip Lattmann, David C. Billington, Yodchai Bunprakob and Jintana Sattayasai
DOI: 10.2174/157018006775240935

Evaluation of 2,3,4,8,13a Hexahydro-1H-Benzo[5,6]Cyclohepta-6,7- Dihydroxy[1,2,3-ef][3]Benzazepine Derivatives as Dopamine Receptor Ligands open Access plus

Volume:3   Issue:1
Pp: 55-60
P. Sozio, F. Pinnen, A. Cocco, I. Cacciatore, G. Giorgioni, B. Costa, M. Montali, G. Spoto, F. Santoleri and Antonio Di Stefano
DOI: 10.2174/157018006775240971

Pyrrolo[3,4-c]Quinoline-1,3-Diones as Potent Caspase-3 Inhibitors: Synthesis and SAR of 8-Sulfamoyl-1,3-Dioxo-2,3-Dihydro-1H-Pyrrolo[3,4- c]Quinolines open Access plus

Volume:3   Issue:1
Pp: 61-70
Dmitri V. Kravchenko, Julia A. Kuzovkova, Volodymyr M. Kysil, Sergey E. Tkachenko, Sergey Malarchuk, Ilya M. Okun and Alexandre V. Ivachtchenko
DOI: 10.2174/157018006775240908