Letters in Drug Design & Discovery

Editor-in-Chief
K. Kuca
University of Hradec Kralove
Hradec Kralove
Czech Republic

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Graphical Abstracts open Access plus

Volume:2   Issue: 1
Pp: v-v

DOI: 10.2174/157018081050201000v

RNA Silencing Technologies in Drug Discovery and Target Validation open Access plus

Volume:2   Issue: 1
Pp: 1-18
Elizabeth Rayburn, Hui Wang, Jie He and Ruiwen Zhang
DOI: 10.2174/1570180053398325

Inhibition of Transforming Growth Factor- βActivation is a Novel Effect of Chymase Inactivation open Access plus

Volume:2   Issue: 1
Pp: 19-22
S. Takai and M. Miyazaki
DOI: 10.2174/1570180053398433

In-Vitro Searching for a New Potent Reactivator of Acetylcholinesterase Inhibited by Nerve Agent VX open Access plus

Volume:2   Issue: 1
Pp: 23-25
K. Kuca, J. Cabal, J. Bajgar and D. Jun
DOI: 10.2174/1570180053398398

Farnesyltransferase Inhibitors: Overview of their Action and Role in Solid Malignancy Therapy open Access plus

Volume:2   Issue: 1
Pp: 26-35
Stefano Margaritora, Alfredo Cesario, Venanzio Porziella, Pierluigi Granone, Alessia Catassi and Patrizia Russo
DOI: 10.2174/1570180053398361

2,3,4,5- Tetrahydro- 1-Benzoxepines a Novel Class of Anti-Implantation Agents open Access plus

Volume:2   Issue: 1
Pp: 36-39
Vishnu K. Tandon and Sanjay Rai
DOI: 10.2174/1570180053398253

Design of a Heteroaryl Modified, 1,5-Disubstituted Pyrazole Cyclooxygenase-2 (COX-2) Selective Inhibitor open Access plus

Volume:2   Issue: 1
Pp: 40-43
M. Ezawa, D. S. Garvey, D. R. Janero, S. P. Khanapure, L. G. Letts, A. Martino, R. R. Ranatunge, D. J. Schwalb and D. V. Young
DOI: 10.2174/1570180053398451

L-Carnitine Effect upon Iron Growth Inhibition on Saccharomyces cerevisiae open Access plus

Volume:2   Issue: 1
Pp: 44-47
C. A. Stella, H. I. Burgos, M. Salellas, M. L. Cristaldo, E. H. Ramos and N. Kriguer
DOI: 10.2174/1570180053398415

Design and Synthesis of Combinatorial Scaffolds-Diazepinone and Homopiperazine open Access plus

Volume:2   Issue: 1
Pp: 48-50
Chung-Ming Sun
DOI: 10.2174/1570180053398280

Solution-Phase Parallel Synthesis of N,6-Disubstituted Isoquinuclidines as Ibogaine Analogs open Access plus

Volume:2   Issue: 1
Pp: 51-54
M. S. Levi, M. O.F. Khan and R. F. Borne
DOI: 10.2174/1570180053398217

Synthesis and Biological Activity of C-8 Fluoroaryl Substituted Pyrimidine Linked-Pyrrolobenzodiazepine Conjugates open Access plus

Volume:2   Issue: 1
Pp: 55-61
Ahmed Kamal, K. Laxma Reddy, V. Devaiah, N. Shankaraiah, M. Shiva Kumar and G. Suresh Kumar Reddy
DOI: 10.2174/1570180053398343

Design, Synthesis and Pharmacological Evaluation of New Nonsteroidal Antiinflammatory 1,3,4-Thiadiazole Derivatives open Access plus

Volume:2   Issue: 1
Pp: 62-67
L. S. Varandas, C. A.M. Fraga, A. L.P. Miranda and E. J. Barreiro
DOI: 10.2174/1570180053398235

Pharmacological Profile of New Deamino Analogues of Sabarubicin (MEN 10755) open Access plus

Volume:2   Issue: 1
Pp: 68-73
M. Bigioni, C. Salvatore, A. Cipollone, M. Berettoni, C. A. Maggi and M. Binaschi
DOI: 10.2174/1570180053398307

Exploiting the Ubiquitin-Proteasome Pathway for Anticancer Drug Discovery: Unanswered Questions and Future Directions open Access plus

Volume:2   Issue: 1
Pp: 74-81
D. M. Smith, K. G. Daniel and Q. P. Dou
DOI: 10.2174/1570180053398406

Author Index to Volume 1 open Access plus

Volume:2   Issue: 1
Pp: 82-85
Bentham Science Publishers
DOI: 10.2174/1570180053398479

Subject Index to Volume 1 open Access plus

Volume:2   Issue: 1
Pp: 86-91
Bentham Science Publishers
DOI: 10.2174/1570180053398299