Letters in Drug Design & Discovery

Editor-in-Chief
K. Kuca
University of Hradec Kralove
Hradec Kralove
Czech Republic

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Volume:15   Issue: 4
Pp: 335-335
James David Adams
DOI: 10.2174/157018081504180312110402



Synthesis, Anti-Methicillin-resistant S. aureus (MRSA) Evaluation, Quantitative Structure-Activity Relationship and Molecular Modeling Studies of Some Novel Bis-indoles as Prospective MRSA Pyruvate Kinase Inhibitors

Volume:15   Issue: 4
Pp: 336-346
Mardia T. El Sayed*, Nermien M. Sabry, Nehal A. Hamdy, Andrey Voronkov, Ifedayo V. Ogungbe, Konstantin Balakin and Mohamed S. Abdel-Aziz
DOI: 10.2174/1570180815666171213144922




Microwave-assisted Synthesis and Antifungal Activity of Novel 1,2,4- Triazole Thioether Derivatives Containing Pyrimidine Moiety

Volume:15   Issue: 4
Pp: 347-352
Meng Xu, Ya-Bo Zhu, Mei Wang, Ikhlas A. Khan, Xing-Hai Liu and Jian-Quan Weng*
DOI: 10.2174/1570180814666170602082440




Anti-MRSA (Multidrug Resistant Staphylococcus aureus) Activity of 3-Substituted Coumarins

Volume:15   Issue: 4
Pp: 353-362
Uzma Salar, Khalid Mohammed Khan*, Humaira Muhammad, Muhammed Imran Fakhri, Sanaullah, Shahnaz Perveen and Muhammed Iqbal Choudhary
DOI: 10.2174/1570180814666170619121844




Synthesis and Anti-influenza Activity of Novel Thiadiazole, Oxadiazole and Triazole Based Scaffolds

Volume:15   Issue: 4
Pp: 363-374
Samar S. Tawfik, Abdelbasset A. Farahat*, Magda A.-A El-Sayed, Atif S. Tantawy, Ola Bagato and Mohamed A. Ali
DOI: 10.2174/1570180814666170512122832




Exploration of Some Thiazolidine-2,4-dione and 2-Oxoindoline Derivatives Incorporating 3,4,5-Trimethoxybenzyl Moiety as Novel Anticancer Agents

Volume:15   Issue: 4
Pp: 375-387
Le Cong Huan, Hai Pham-The, Huong Le-Thi-Thu, Tran Phuong Thao, Do Nguyet Que, Nguyen-Thu Trang, Phan Thi Phuong Dung, Minji Pyo, Sang-Bae Han, Nguyen Thi Thuan* and Nguyen-Hai Nam*
DOI: 10.2174/1570180814666170605122552




Design, Synthesis and Biological Evaluation of Some Novel Thiazole-2- Carboxamide Derivatives as Antitumor Agents

Volume:15   Issue: 4
Pp: 388-397
Haibo Wang*, Zhengjiang Cai, Shan Zheng, Huidan Ma, Haiming Lin and Xiaohe Zheng*
DOI: 10.2174/1570180814666170704143015




Design, Synthesis, and Screening of Hybrid Benzothiazolyl-Oxadiazoles as Anticonvulsant Agents

Volume:15   Issue: 4
Pp: 398-405
Sheikh Murtuja, Mohammad Shaquiquzzaman and Mohammad Amir*
DOI: 10.2174/1570180814666170526154914




Synthesis and Evaluation of the Anticonvulsant Activities of New 5-substitued-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one Derivatives

Volume:15   Issue: 4
Pp: 406-413
Guo-Rui Zhang, Yang Ren, Xiu-Mei Yin* and Zhe-Shan Quan
DOI: 10.2174/1570180814666170619094408




Fighting Against Alzheimer's Disease: Synthesis of New Pyrazoline and Benzothiazole Derivatives as New Acetylcholinesterase and MAO Inhibitors

Volume:15   Issue: 4
Pp: 414-427
Gulhan Turan-Zitouni*, Weiam Hussein, Begum Nurpelin Saglik, Merve Baysal and Zafer Asim Kaplancikli
DOI: 10.2174/1570180814666170704144917




Synthesis and Urease Inhibitory Activity of Some 5-Aminomethylene Barbituric/Thiobarbituric Acid Derivatives

Volume:15   Issue: 4
Pp: 428-436
Mehdi Asadi, Mohammad Mahdavi, Shabnam Mahernia, Zahra Rezaei, Maliheh Safavi, Mina Saeedi and Massoud Amanlou*
DOI: 10.2174/1570180814666170727142928




Design, Synthesis and Pharmacological Evaluation of Some Novel Tetrahydrocarbazoles as Potential COX-2 Inhibitors

Volume:15   Issue: 4
Pp: 437-449
Padmavathi Sakinala, Rupesh Chikhale and Madhukar Tajne*
DOI: 10.2174/1570180814666170602084037