Letters in Drug Design & Discovery

Editor-in-Chief:

George Perry
University of Texas
San Antonio, TX
USA

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Editorial: New Insights on Characterization and Biological Activities of Natural Products free to download

Volume:15   Issue:3
Pp: 219-219
Gokhan Zengin and Marcello Locatelli
DOI: 10.2174/157018081503180131102747



Arginine- and Lysine-rich Peptides: Synthesis, Characterization and Antimicrobial Activity

Volume:15   Issue:3
Pp: 220-226
Adriano Mollica*, Giorgia Macedonio, Azzurra Stefanucci, Roberto Costante, Simone Carradori, Valentina Cataldi, Mara Di Giulio, Luigina Cellini, Romano Silvestri, Cesare Giordano, Anita Scipioni, Stefano Morosetti, Pasqualina Punzi and Sako Mirzaie
DOI: 10.2174/1570180814666170213161341



 In Vitro Evaluation of the Antibacterial Activity and Antibiotic- Modulatory Effect of Gracilaria cervicornis (Tuner) J. Agardh

Volume:15   Issue:3
Pp: 227-230
Israeliane F. Cordeiro, Henrique D. M. Coutinho, Joao V. A. Ferreira, Lucindo J. Quintans Junior*, Irwin R. A. Menezes, Micheline A. Lima, Thiago S. Freitas, Maria Isabeli P. Goncalo, Francisco Licaon G. Rocha, Rivio Fabricio de F. Furtado and Jacqueline C. Andrade
DOI: 10.2174/1570180814666170309094910



 Characterization and Evaluation of the Antioxidant Activity of Calamusenone, a Major Component of Hyptis pectinata (L.) Poit Essential Oil

Volume:15   Issue:3
Pp: 231-239
Mairim R. Serafini*, Daviane M.C. Vergne, Paula P. Menezes, Joao P.A. Santos, Thallita K. Rabelo, Shanmugam Saravanan, Pericles B. Alves, Emmanoel V. Costa, Hugo Cesar R. Jesus, Marcos J. Salvador, Daniel P. Gelain, Jose C.F. Moreira, Ricardo F. Rocha, Adriano A.S. Araujo* and Lucindo J. Quintans-Junior*
DOI: 10.2174/1570180814666170309130728



 Solvent-free Mechano-chemical Synthesis of New Omeprazole Derived Metal Complexes: Characterization, Urease Inhibitory Kinetics and Selective Anti-Helicobacter pylori Activity

Volume:15   Issue:3
Pp: 240-250
Muhammad Amin*, Farooq Anwar, Mahmood Anwar, Abdul Karim, Khalid M. Alkharfy and Anwarul-Hassan Gilani*
DOI: 10.2174/1570180814666170309130030



 Effects of Asphodeline lutea Compounds on Toxicity Models in Isolated Rat Microsomes and Hepatocytes

Volume:15   Issue:3
Pp: 251-255
Magdalena Kondeva-Burdina, Rumyana Simeonova, Vessela Vitcheva, Irina Lazarova*, Reneta Gevrenova, Dimitrina Zheleva-Dimitrova, Gokhan Zengin and Nikolay D. Danchev
DOI: 10.2174/1570180814666170306122707



 Inhibitory Effects of Flavonolignans from Silybum marianum (L.) Gaertn (Milk Thistle) on Function of Aldehyde Oxidase and Xanthine Oxidase in Rats

Volume:15   Issue:3
Pp: 256-262
Nafiseh Alizadeh, Morteza Eskandani, Khalil Tondro, Mohamad-Reza Rashidi and Hossein Nazemiyeh*
DOI: 10.2174/1570180814666170420110005



 Chemical Constituent and Biological Activities of Spatoglossum asperum J. Agardh from Oman Sea

Volume:15   Issue:3
Pp: 263-269
Nasrin Movahhedin*, Hossein Nazemiyeh*, Jaleh Barar, Solmaz Esnaashari and Amir Hossein Movahhedin
DOI: 10.2174/1570180814666170407103936



 Herbal Medicines: Application of a Sequential Voltammetric Procedure to the Determination of Mercury, Copper, Lead, Cadmium and Zinc at Trace Level

Volume:15   Issue:3
Pp: 270-280
Dora Melucci, Marcello Locatelli, Francesco De Laurentiis, Gokhan Zengin and Clinio Locatelli*
DOI: 10.2174/1570180814666170412124634



 Analytical Procedures for Secondary Metabolites Determination: Recent Trends and Future Perspectives

Volume:15   Issue:3
Pp: 281-293
Luigi Menghini, Giuseppe Bellagamba, Marcelli Fabiana, Elisa De Luca, Luca Armellani, Roberta Cifelli, Arianna Granese, Nilgun Zengin Kucukerkan, Abdurrahman Aktumsek and Gokhan Zengin*
DOI: 10.2174/1570180814666170505124707



 Novel 11,12H-dihydronaphthalene[1,2-b]quinoline as Atypical Antipsychotic

Volume:15   Issue:3
Pp: 294-303
Maria Matilde Ramirez Moran, Jorge Eduardo Angel Guio*, Natividad Herrera Cano, Biagina del Carmen Migliore, Rodolfo Izquierdo, Jaime Charris, Simon Lopez, Anita Israel, Ana Santiago, Roberto Rossi, Luis Perdomo, Akram Samear Dabian, Mariagracia Vera Sosa, Alejandra Villalba and Ligia Biagina Angel Migliore
DOI: 10.2174/1570180814666170704144246



 3D-QSAR Studies of 1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones Derivatives as RSV Fusion Inhibitors

Volume:15   Issue:3
Pp: 304-315
Lian Liu, Yuanhao Zhai, Yiqun Chang, Wen Yan, Ruoshi Huang, Pinghua Sun, Wenzhu Huang* and Jialiang Guo*
DOI: 10.2174/1570180814666170727144943



 Gastroprotective Activity of Hydroalcoholic Extract of the Stryphnodendron rotundifolium Mart. in Mice: Mechanism Actions Assay

Volume:15   Issue:3
Pp: 316-324
Dayanne Rakelle de Oliveira, Lucindo Jose Quintans-Junior*, Thais Rodrigues de Albuquerque, Francisco Elizaudo de Brito Junior, Cicera Norma Fernandes, Heloisa Helena Fernandes de Souza, Aline Augusti Boligon, Margareth Linde Athayde, Cicero Bezerra Felipe, Henrique Douglas Melo Coutinho, Roseli Barbosa, Marta Regina Kerntopf and Irwin Rose Alencar de Menezes*
DOI: 10.2174/1570180814666170213154951



 Antimicrobial, Gastroprotective and Healing Effect of the Hydroalcoholic Extract of Astronium fraxinifolium

Volume:15   Issue:3
Pp: 325-334
Anita Oliveira Brito Pereira Bezerra Martins, Ana Luiza Albuquerque Siebra, Cicera Datiane de Morais Oliveira, Gerlania Oliveira Leite, Henrique Douglas Melo Coutinho, Margareth Linde Athayde, Aline Augusti Bolignon, Jacqueline Cosmo Andrade, Larissa Rolim Oliveira, Marta Regina Kerntopf, Roseli Barbosa, Francisco Rafael Alves Santana Cesario, Thales Silva Coutinho, Lucindo Jose Quintans-Junior and Irwin Rose Alencar de Menezes*
DOI: 10.2174/1570180814666170213160114