Letters in Drug Design & Discovery

Editor-in-Chief
K. Kuca
University of Hradec Kralove
Hradec Kralove
Czech Republic

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Structure-based Drugs Design Studies on Spleen Tyrosine Kinase Inhibitors

Volume:13   Issue: 9
Pp: 845-858
Letícia Cristina Assis, Letícia Santos Garcia, Daiana Teixeira Mancini, Tamiris Maria Assis, Daniela Rodrigues Silva, Giovanna Gajo Cardoso, Alexandre Alves de Castro, Teodorico Castro Ramalho and Elaine Fontes Ferreira da Cunha
DOI: 10.2174/1570180813666160725095118




In-silico Designing of Novel Camptothecin Analogues as Potent Inhibitors of Topoisomerase I: A Molecular Docking, QSAR, and ADME-T Study

Volume:13   Issue: 9
Pp: 859-868
Darpan Raghav, Babukrishna Maniyadath, Aruna Mohan, Sutari Sairam, Rinu Mary Rajan and Krishnan Rathinasamy
DOI: 10.2174/1570180813666160518123550




Synthesis, Biological Evaluation and in silico Studies of Novel 5α-aza-Bhomo-3,5-secosteroids as Potential 5-reductase Inhibitors

Volume:13   Issue: 9
Pp: 869-878
Rajnish Kumar, Pankaj Chauhan, Priyanka Malla, Manoj K. Mahapatra, Rolf W. Hartmann, Jörg Haupenthal and Manoj Kumar
DOI: 10.2174/1570180813666160630110649




Imidazole-based Derivatives as Potential Anti-platelet Inhibitors: DFT and Molecular Docking Study

Volume:13   Issue: 9
Pp: 888-896
Mehbub I. K. Momin, Neil A. Koorbanally and Bahareh Honarparvar
DOI: 10.2174/1570180813666160517162937




Synthesis and Antiacetylcholinesterase Activity Evaluation of New 2-aryl Benzofuran Derivatives

Volume:13   Issue: 9
Pp: 897-902
Behjat Pouramiri, Mohammad Mahdavi, Setareh Moghimi, Loghman Firoozpour, Hamid Nadri, Alireza Moradi, Esmat Tavakolinejad-Kermani, Ali Asadipour and Alireza Foroumadi
DOI: 10.2174/1570180813666160610124637




Synthesis and Evaluation of New Thiazole Derivatives as Potential Antimicrobial Agents

Volume:13   Issue: 9
Pp: 903-911
Mehlika Dilek Altıntop, Ahmet Özdemir, Özlem Atlı, Zerrin Cantürk, Merve Baysal and Zafer Asım Kaplancıklı
DOI: 10.2174/1570180813666160226001021




Synthesis and In vivo Antifibrotic Activity of Novel Leflunomide Analogues

Volume:13   Issue: 9
Pp: 912-920
Abdelrahman Hamdi, Eman Said, Abdelbasset A. Farahat, Serry A. A. El-Bialy and Mohammed A. M. Massoud
DOI: 10.2174/1570180813666160630125624




Synthesis and Antimicrobial Evaluation of New Pyrazoline and Pyrazolinyl Thiazole Derivatives Bearing Tetrazolo[1,5-a]quinoline Moiety

Volume:13   Issue: 9
Pp: 921-931
Ibrahim A. M. Radini, Rizk E. Khidre and Emad M. El-Telbani
DOI: 10.2174/1570180813666160712234454




Design, Synthesis and Antimalarial Activity of Some New Aminoalcoholpyrrolo[1,2-a]quinoxaline Derivatives

Volume:13   Issue: 9
Pp: 932-942
Jean Guillon, Stéphane Moreau, Luisa Ronga, Louise Basmacyian, Anita Cohen, Sandra Rubio, Guillaume Bentzinger, Solène Savrimoutou, Nadine Azas, Catherine Mullié and Pascal Sonnet
DOI: 10.2174/1570180813666160517164758




Significance of Amino Group Substitution at Combretastatin A-4 and Phenstatin Analogs

Volume:13   Issue: 9
Pp: 943-951
Vijay K. Patel and Harish Rajak
DOI: 10.2174/1570180813666160517163444




Study of Some Piperine Analogues on Drugs Efflux by Targeting P-glycoprotein, an in silico Approach

Volume:13   Issue: 9
Pp: 952-961
Anushree Tripathi, Krishna Misra and Rajesh Kumar Kesharwani
DOI: 10.2174/1570180813999160830102312




Sodium Channel Blocking Activity and In-vivo Testing of New Phenylimidazole Derivatives

Volume:13   Issue: 9
Pp: 962-967
Mirko Rivara, Manoj K. Patel, Alberto Rapalli and Valentina Zuliani
DOI: 10.2174/1570180813666160714125755




An Efficient Nonconventional Glycerol-Based Solid Acid Catalyzed Synthesis and Biological Evaluation of Phosphonate Conjugates of 1,2,4-triazole Thiones

Volume:13   Issue: 9
Pp: 968-981
Madugula S. R. Murty, Mohana R. Katiki, Busam R. Rao, Sai S. Narayanan, Ruby J. Anto, Sudhreer K. Buddana, Reddy S. Prakasham, Bethala L. A. P. Devi and Rachapudi B. N. Prasad
DOI: 10.2174/1570180813666160125222334




Design, Synthesis and Molecular Docking Studies of 2-Aryl/Heteroaryl-Ethyl 6-Chloroquinoline-4-Carboxylates as Potential Antimalarial Agents

Volume:13   Issue: 9
Pp: 982-991
Thamatakallu O. S. Kumar, Kittappa M. Mahadevan, Pasura S. Sujanganapathy and Manikyanahally N. Kumara
DOI: 10.2174/1570180813666160722112725