Letters in Drug Design & Discovery

Editor-in-Chief
K. Kuca
University of Hradec Kralove
Hradec Kralove
Czech Republic

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In Vitro and In Vivo Investigations into the Carbene Copper Bromide Anticancer Drug Candidate WBC4

Volume:11   Issue: 7
Pp: 825-832
Wolfgang Walther, Iduna Fichtner, Frauke Hackenberg, Wojciech Streciwilk and Matthias Tacke
DOI: 10.2174/1570180811666140529004102

Synthesis and Anticancer Activity of 2,4,5-triaryl Imidazole Derivatives

Volume:11   Issue: 7
Pp: 840-843
Fatemeh Elahian, Morteza Akbari, Maryam Ghasemi, Neda Behtooee, Mohaddeseh Taheri and Mohsen Amini
DOI: 10.2174/1570180811666140313233659

Detour Cum Distance Matrix Based Topological Descriptors for QSAR/QSPR Part-I: Development and Evaluation

Volume:11   Issue: 7
Pp: 844-863
Monika Gupta, Harish Jangra, Prasad V. Bharatam and Anil K. Madan
DOI: 10.2174/1570180811999140605111741

Identification of Potential MEK1 Inhibitors by Pharmacophore-based Virtual Screening and MD Simulations

Volume:11   Issue: 7
Pp: 894-907
Huanhuan Shi, Lu Zhou, Guangkai Bao, Qianying Yi, Suwen Zhou, Yahui Tian and Xiaoli Li
DOI: 10.2174/1570180811666140423221748

Anionic Linear Globular Dendrimer-G2-Ciprofloxacin Nano-Conjugate: Novel Agent against Wilson Disease Cell Model

Volume:11   Issue: 7
Pp: 908-916
Narges Karimi, Mohammad Reza Aghasadeghi, Parichehr Yaghmaei, Hadi Fathi Moghaddam, Nasser Nassiri-Koopaei, Hamid Moloudian, Saleh Najafi, Seyed Ataaollah Shandiz and Mehdi Shafiee Ardestani
DOI: 10.2174/1570180811666140322001829

4'-Modified Pyrimidine Nucleosides as Potential Anti-hepatitis C Virus (HCV) Agents

Volume:11   Issue: 7
Pp: 917-921
Neeraj Shakya, Satish Vedi, Chao Liang, Babita Agrawal and Rakesh Kumar
DOI: 10.2174/1570180811666140401184856

Preparation of Supramolecular Hydrogels Containing Poloxamers and Methyl-β-cyclodextrin

Volume:11   Issue: 7
Pp: 922-929
Maria Joao Garcia, Joana Ruivo, Rita Oliveira and Ana Figueiras
DOI: 10.2174/1570180811666140220005117

Synthesis of Novel and Highly Functionalized Pyrimidine-5-carboxylate Derivatives and their Antimicrobial Evaluation

Volume:11   Issue: 7
Pp: 930-936
Hardik B. Ghodasara, Rajesh G. Vaghasiya, Bharat G. Patel and Viresh H. Shah
DOI: 10.2174/1570180811666140401182419

In Vivo Assessment of Antileishmanial Property of 4-(4,4,8-Trimethyl-7- oxo-3-oxabicyclo[3.3.1]non-2-yl)-benzoic Acid Methyl Ester, an Oxabicyclo[ 3.3.1]nonanones

Volume:11   Issue: 7
Pp: 937-939
Prakash Saudagar, Shyam Lal Mudavath, Pipas Saha, Anil K. Saikia, Shyam Sundar and Vikash Kumar Dubey
DOI: 10.2174/1570180811666140423203826

Synthesis and Antifungal Activity of 1,2,3-thiadiazole Derivatives Containing 1,3,4-thiadiazole Moiety

Volume:11   Issue: 7
Pp: 940-943
Shui-Lin Yan, Ming-Yan Yang, Zhao-Hui Sun, Li-Jing Min, Cheng-Xia Tan, Jian-Quan Weng, Hong-Ke Wu and Xing-Hai Liu
DOI: 10.2174/1570180811666140423222141

In Vitro Screening of Some Heterocyclic Compounds Against Human ABHD6 and ABHD12 Hydrolases

Volume:11   Issue: 7
Pp: 944-952
Agnieszka A. Kaczor, Antti Poso and Monika Pitucha
DOI: 10.2174/1570180811666140313233940