Letters in Drug Design & Discovery

Editor-in-Chief:

George Perry
University of Texas
San Antonio, TX
USA

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Volume:11   Issue:3
Pp: i-vii

DOI: 10.2174/157018081103140203152259

Molecular Modeling and Docking Application to Evaluate Cruzain Inhibitory Activity by Chalcones and Hydrazides

Volume:11   Issue:3
Pp: 249-255
Drielli Gomes Vital, Marco Arribas and Gustavo Henrique Goulart Trossini
DOI: 10.2174/15701808113106660082

Synthesis and Anti-Proliferative Activity of New Biphenyle-Benzylidenethiazolidine- 2,4-dione Bis-Adducts Containing Various Heterocyclic Cores

Volume:11   Issue:3
Pp: 256-264
Maxime Meyer, Sandra Kuntz, Isabelle Grillier-Vuissoz, Helene Martin, Lysiane Richert, Stephane Flament, Yves Chapleur and Michel Boisbrun
DOI: 10.2174/15701808113106660080

Prediction of the Estrogen Receptor Binding Affinity for both hERα and hERβ by QSAR Approaches

Volume:11   Issue:3
Pp: 265-278
Changliang Deng, Xuanxuan Chen, Hongying Lu, Xin Yang, Feng Luan and Maria Natalia Dias Soeiro Cordeiro
DOI: 10.2174/15701808113109990067

Synthesis of Sulfur Containing Colchicine Derivatives and their Biological Evaluation as Cytotoxic Agents

Volume:11   Issue:3
Pp: 279-289
Joanna Kurek, Wladyslaw Boczon, Krzysztof Myszkowski, Marek Murias, Teresa Borowiak and Irena Wolska
DOI: 10.2174/15701808113106660086

Synthesis, Characterization, Antimycobacterial and Anticancer Evaluation of New 1,2,4-Triazole Derivatives

Volume:11   Issue:3
Pp: 290-296
G. Cihan-Ustundag, B. Simsek, E. Ilhan and G. Capan
DOI: 10.2174/157018081131000074

Triazole-linked Chalcone and Flavone Hybrid Compounds Based on AZT Exhibiting In Vitro Anti-Cancer Activity

Volume:11   Issue:3
Pp: 297-303
Nguyen Van Minh, Nguyen Le Anh, Do Thi Thao and Tran Khac Vu
DOI: 10.2174/157018081131000073

Synthesis, Evaluation and Molecular Docking Studies of 1,3,4-oxadiazole- 2-thiol Incorporating Fatty Acid Moiety as Antitumor and Antimicrobial Agents

Volume:11   Issue:3
Pp: 304-315
Fatma Salah El-Din Mohamed, Ahmed Ismail Hashem, Randa Helmy Swellem and Galal Abd El-Moaen Mohamed Nawwar
DOI: 10.2174/157018081131000072

Pharmacophore and 3D QSAR Study of TGFβ Inhibitors

Volume:11   Issue:3
Pp: 316-330
Mohamed Asraf Vazhapully, D. Vinod and N.H. Zeinul Hukuman
DOI: 10.2174/157018081131000071

Design and Synthesis of New Dual Binding Site Cholinesterase Inhibitors: in vitro Inhibition Studies with in silico Docking open access plus

Volume:11   Issue:3
Pp: 331-338
Muhammad Yar, Marek Bajda, Rana Atif Mehmood, Lala Rukh Sidra, Nisar Ullah, Lubna Shahzadi, Muhammad Ashraf, Tayaba Ismail, Sohail Anjum Shahzad, Zulfiqar Ali Khan, Syed Ali Raza Naqvi and Nasir Mahmood
DOI: 10.2174/15701808113106660078

A Combination of Pharmacophore and In silico Approaches for Identification of Potential Transthyretin Amyloidosis Inhibitors

Volume:11   Issue:3
Pp: 339-348
Zheng-Li Zhou, Hsuan-Liang Liu, Josephine W. Wu, Cheng-Wen Tsao, Wei-Hsi Chen, Kung-Tien Liu and Yih Ho
DOI: 10.2174/15701808113106660077

Synthesis and In Vitro Evaluation of Some Hydrazone Derivatives as Potential Antibacterial Agents

Volume:11   Issue:3
Pp: 355-362
Zafer Asim Kaplancikli, Mehlika Dilek Altintop, Ahmet Ozdemir, Gulhan Turan-Zitouni, Gamze Goger and Fatih Demirci
DOI: 10.2174/15701808113109990030

Identification of Interfacial Residues Involved in Hepcidin-Ferroportin Interaction

Volume:11   Issue:3
Pp: 363-374
Prasoon Kumar Thakur, Amresh Prakash, Parvez Khan, Robert E. Fleming, Abdul Waheed, Faizan Ahmad and Md. Imtaiyaz Hassan
DOI: 10.2174/15701808113106660088

Synthesis and Ultraviolet Absorption Characteristics of Chiral 3- arylidenenopinones from β-pinene

Volume:11   Issue:3
Pp: 380-386
Xu Xu, Yi-Qin Yang, Hai-Jun Xu, Lan Lan and Shi-Fa Wang
DOI: 10.2174/15701808113106660095