Letters in Drug Design & Discovery

Editor-in-Chief:

George Perry
University of Texas
San Antonio, TX
USA

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Editor's Choice

Potential of Nanoparticles in Combating Candida Infections

Volume: 16   Issue: 5
Pp: 478-491
Faizan Abul Qais, Mohd Sajjad Ahmad Khan, Iqbal Ahmad* and Abdullah Safar Althubiani
DOI: 10.2174/1570180815666181015145224

Synthesis and Evaluation of Chalcone and its Derivatives as Potential Anticholinergic Agents

Volume: 16   Issue: 3
Pp: 322-332
Shahzad Murtaza*, Khoula Zubair Mir, Adina Tatheer and Raja Summe Ullah
DOI: 10.2174/1570180815666180523085436

Synthesis and Antichlamydial Activity of Novel Phenazines

Volume: 16   Issue: 2
Pp: 174-181
Xiaofeng Bao, Xiaowei Yu, Chao Xia, Ningjing Yang, Shengju Yang* and Yu Zhao*
DOI: 10.2174/1570180815666180518112952

A New Class of Pure Estrogen Alpha Receptor Antagonists; Design, Synthesis and in-vitro Screening

Volume: 16   Issue: 1
Pp: 66-81
Akbar John Jameera Begam, Katike Ahamed Basheer, Selvaraj Jubie*, Srikanth Jupudi, Mohammed Afzal Azam and Palanisamy Dhanabal
DOI: 10.2174/1570180815666180327124634

Preparation and Characterization of GLUT1-mediated Novel Brain Targeting Magnetic Nanoparticles

Volume: 15   Issue: 12
Pp: 1308-1313
Li Zhang, Yi Zhao, Qiming Yue, Qiuyi Fu, Li Hai, Li Guo, Qiantao Wang* and Yong Wu*
DOI: 10.2174/1570180815666180322113934

Synthesis and Mosquiticidal Activity of Novel Hydrazone Containing Pyrimidine Derivatives against Aedes aegypti

Volume: 15   Issue: 9
Pp: 951-956
Zhong-Hua Shen, Zhao-Hui Sun, James J. Becnel, Alden Estep, David E. Wedge*, Cheng-Xia Tan, Jian-Quan Weng, Liang Han and Xing-Hai Liu*
DOI: 10.2174/1570180815666180102141640

Inhibitory Effects of 1,4-disubstituted Thiosemicarbazide Derivatives on Streptococcus mutans and Streptococcus sanguinis Mono-species Biofilms

Volume: 15   Issue: 8
Pp: 843-850
Malgorzata Miazga-Karska, Maciej Wos, Agnieszka A. Kaczor, Anna Pachuta-Stec, Grazyna Ginalska and Monika Pitucha*
DOI: 10.2174/1570180814666171012164241

Enhancement Antimicrobial Activity of Clarithromycin by Amine Functionalized Mesoporous Silica Nanoparticles as Drug Delivery System

Volume: 15   Issue: 7
Pp: 787-795
Pegah Khosravian, Mehdi Khoobi, Mehdi Shafiee Ardestani, Mohammad Porgham Daryasari, Malihe Hassanzadeh, Payam Ghasemi-Dehkordi, Massoud Amanlou and Hamid Akbari Javar*
DOI: 10.2174/1570180815666180117155818

Synthesis and Mosquitocidal Activity of a Series of Hydrazone Derivatives against Aedes aegypti

Volume: 15   Issue: 6
Pp: 671-677
Mehlika Dilek Altintop*, Nurhayat Tabanca, James J. Becnel, Jeffrey R. Bloomquist, Zafer Asim Kaplancikli and Ahmet Ozdemir
DOI: 10.2174/1570180814666171002155548

Fighting Against Alzheimer's Disease: Synthesis of New Pyrazoline and Benzothiazole Derivatives as New Acetylcholinesterase and MAO Inhibitors

Volume: 15   Issue: 4
Pp: 414-427
Gulhan Turan-Zitouni*, Weiam Hussein, Begum Nurpelin Saglik, Merve Baysal and Zafer Asim Kaplancikli
DOI: 10.2174/1570180814666170704144917

Antimicrobial, Gastroprotective and Healing Effect of the Hydroalcoholic Extract of Astronium fraxinifolium

Volume: 15   Issue: 3
Pp: 325-334
Anita Oliveira Brito Pereira Bezerra Martins, Ana Luiza Albuquerque Siebra, Cicera Datiane de Morais Oliveira, Gerlania Oliveira Leite, Henrique Douglas Melo Coutinho, Margareth Linde Athayde, Aline Augusti Bolignon, Jacqueline Cosmo Andrade, Larissa Rolim Oliveira, Marta Regina Kerntopf, Roseli Barbosa, Francisco Rafael Alves Santana Cesario, Thales Silva Coutinho, Lucindo Jose Quintans-Junior and Irwin Rose Alencar de Menezes*
DOI: 10.2174/1570180814666170213160114

Synthesis and Anti-Oxidant Evaluation of Some Novel Sulfa Drugs

Volume: 14   Issue: 12
Pp: 1425-1432
Moustafa A. Gouda* and Belal H.M. Hussein
DOI: 10.2174/1570180814666170607144811

Synthesis and Antimicrobial Activity of Some Novel Substituted 3-(Thiophen-2-yl)pyrazole-based Heterocycles

Volume: 14   Issue: 11
Pp: 1316-1323
Bakr F. Abdel-Wahab*, Abdelbasset A. Farahat, Ghada E. A. Awad and Gamal A. El-Hiti*
DOI: 10.2174/1570180814666170327162447

Development of Xanthine Based Inhibitors Targeting Phosphodiesterase 9A

Volume: 14   Issue: 10
Pp: 1122-1137
Nivedita Singh, Parameswaran Saravanan, M.S. Thakur and Sanjukta Patra*
DOI: 10.2174/1570180813666161102125423

Synthesis, Molecular Docking Studies and Biological Evaluation o f 3-Iminoaurones as Acetylcholinesterase and Butyrylcholinesterase Inhibitors

Volume: 14   Issue: 9
Pp: 1035-1041
Ehsan Ullah Mughal*, Amina Sadiq, Bilal Ahmad Khan, Muhammad Naveed Zafar, Ishtiaq Ahmed and Muhammad Zubair
DOI: 10.2174/1570180814666170106123959

A Facile Synthesis and Drug Design of Some New Heterocyclic Compounds Incorporating Pyridine Moiety and Their Antimicrobial Evaluation

Volume: 14   Issue: 7
Pp: 752-762
Fathy M. Abdelrazek, Sobhi M. Gomha*, Aly H. Abdelrahman, Peter Metz and Mohsen A. Sayed
DOI: 10.2174/1570180814666161128120240

Alzheimer’s Disease Drugs- In Vitro Comparison of Cholinesterase Inhibition and beta-amyloid Modulation

Volume: 14   Issue: 6
Pp: 743-750
Ondrej Holas, Jan Korabecny, Zuzana Gazova, Katarina Siposova, Kamil Musilek, Veronika Opletalova, Lukas Gorecki, Eugenie Nepovimova, Katarina Spilovska, Eva Mezeiova and Kamil Kuca*
DOI: 10.2174/1570180814666161228143846

Synthesis of Novel 4-(Dimethylaminoalkyl)piperazine-1-carbodithioa t e Derivatives as Cholinesterase Inhibitors

Volume: 14   Issue: 5
Pp: 528-539
Ulviye Acar Cevik, Serkan Levent, Begum Nurpelin Saglık, Yusuf Ozkay* and Zafer Asım Kaplancıklı
DOI: 10.2174/1570180813666160923105636

Quinoline Derivatives as Novel Depigmenting and Antioxidant Agents

Volume: 14   Issue: 4
Pp: 374-379
Rebeca Mol Lima, Kauana Cristina de Souza, Jordana de Abreu Lazzarini, Isabela O. Souza, Adilson David da Silva and Nadia Rezende Barbosa Raposo
DOI: 10.2174/1570180813666160930164926

The Disulfide Analogues of Isophosphoramide Mustard for Anticancer Therapy

Volume: 12   Issue: 3
Pp: 172-179
Joanna Cytarska, Krzysztof Skowerski, Szymon Jaworski, Konrad Misiura, Beata Filip-Psurska and Joanna Wietrzyk
DOI: 10.2174/1570180811666141010001007

A Screening Method for Potential Anti-pancreatic Cancer Candidate Compounds Based on Hsp90-Cdc37 Interaction Model in vitro promotion: free to download

Volume: 12   Issue: 1
Pp: 66-71
Hai Zhang, Sen Sun, Qingshan Chen, Guoqing Zhang, Zhenqing Zhang, Duxin Sun and Wenpeng Zhang
DOI: 10.2174/1570180811666140725185235

Modeling the Active Conformation of Human µ Opioid Receptor

Volume: 11   Issue: 9
Pp: 1053-1061
Agnieszka A. Kaczor, Damian Bartuzi and Dariusz Matosiuk
DOI: 10.2174/1570180811666140322001506

In Vitro and In Vivo Investigations into the Carbene Copper Bromide Anticancer Drug Candidate WBC4

Volume: 11   Issue: 7
Pp: 825-832
Wolfgang Walther, Iduna Fichtner, Frauke Hackenberg, Wojciech Streciwilk and Matthias Tacke
DOI: 10.2174/1570180811666140529004102

Analysis of Proteasome Inhibition Prediction Using Atom-Based Quadratic Indices Enhanced by Machine Learning Classification Techniques

Volume: 11   Issue: 6
Pp: 705-711
Gerardo M. Casanola-Martin, Huong Le-Thi-Thu, Yovani Marrero-Ponce, Juan A Castillo- Garit, Francisco Torrens, Facundo Perez-Gimenez and Concepcion Abad
DOI: 10.2174/1570180811666140122001144

Potent Neuroprotective Activity of Monoterpene Derived 4-[(3aR,7aS)- 1,3,3a,4,5,7a-Hexahydro-3,3,6-trimethylisobenzofuran-1-yl]-2-methoxyphenol in MPTP Mice Model

Volume: 11   Issue: 5
Pp: 611-617
Alla V. Pavlova, Irina V. Il'ina, Ekaterina A. Morozova, Dina V. Korchagina, Svetlana Yu. Kurbakova, Irina V. Sorokina, Tatyana G. Tolstikova, Konstantin P. Volcho and Nariman F. Salakhutdinov
DOI: 10.2174/1570180811666131210000316

Synthesis and Anti-Proliferative Activity of New Biphenyle-Benzylidenethiazolidine- 2,4-dione Bis-Adducts Containing Various Heterocyclic Cores

Volume: 11   Issue: 3
Pp: 256-264
Maxime Meyer, Sandra Kuntz, Isabelle Grillier-Vuissoz, Helene Martin, Lysiane Richert, Stephane Flament, Yves Chapleur and Michel Boisbrun
DOI: 10.2174/15701808113106660080

Biochemical Changes Evidenced in Alzheimer's Disease: A Mini-Review

Volume: 11   Issue: 2
Pp: 240-248
Luciana Scotti, Francisco Jaime Bezerra Mendonça Junior, Marcelo Sobral da Silva, Ivan R. Pitta and Marcus Tullius Scotti
DOI: 10.2174/15701808113109990063

Improvement of Virtual Screening Predictions using Computational Intelligence Methods promotion: free to download

Volume: 11   Issue: 1
Pp: 33-39
Gaspar Cano, José García-Rodríguez and Horacio Pérez-Sánchez
DOI: 10.2174/15701808113109990054