Letters in Drug Design & Discovery

Editor-in-Chief
K. Kuca
University of Hradec Kralove
Hradec Kralove
Czech Republic

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Most Cited Article

Synthesis and Mosquiticidal Activity of Novel Hydrazone Containing Pyrimidine Derivatives against Aedes aegypti

Volume:15   Issue:9
Pp: 951-956
Zhong-Hua Shen, Zhao-Hui Sun, James J. Becnel, Alden Estep, David E. Wedge*, Cheng-Xia Tan, Jian-Quan Weng, Liang Han and Xing-Hai Liu*
DOI: 10.2174/1570180815666180102141640

Synthesis and Antifungal Activity of Some 6-tert-butyl-8-chloro-2, 3-dimethylquinolin-4-ol Derivatives against Pyricularia oryae

Volume:15   Issue:12
Pp: 1314-1318
Yue-Ming Fang, Rui-Rui Zhang, Zhong-Hua Shen, Cheng-Xia Tan, Jian-Quan Weng, Tian-Ming Xu*, Xing-Hai Liu*, Hong-Ying Huang and Hong-Ke Wu
DOI: 10.2174/1570180815666180313121735

Synthesis, Nematicidal Activity and Docking Study of Novel Pyrazole-4-Carboxamide Derivatives Against Meloidogyne incognita

Volume:16   Issue:1
Pp: 29-35
Long Cheng, Wen Zhao, Zhong-Hua Shen, Tian-Ming Xu, Hong-Ke Wu, Wei-Li Peng* and Xing-Hai Liu*
DOI: 10.2174/1570180815666180326150827

Novel Trifluoromethylpyrazole Acyl Thiourea Derivatives: Synthesis, Antifungal Activity and Docking Study

Volume:16   Issue:7
Pp: 785-791
Han Wang, Zhi-Wen Zhai, Yan-Xia Shi, Cheng-Xia Tan, Jian-Quan Weng, Liang Han, Bao-Ju Li and Xing-Hai Liu*
DOI: 10.2174/1570180815666180704103047

Computational Approach to the Discovery of Phytochemical Molecules with Therapeutic Potential Targets to the PKCZ protein

Volume:15   Issue:5
Pp: 488-499
Poliany G. Freitas*, Thiago C. Elias, Icaro A. Pinto, Luciano T. Costa, Paulo V.S.D. de Carvalho, Daniel de Q. Omote, Ihosvany Camps, Tati Ishikawa, Helen A. Arcuri, Susana Vinga, Arlindo L. Oliveira, Walter F.A. Junior and Nelson J.F. da Silveira
DOI: 10.2174/1570180814666170810120150

Synthesis, Biological Evaluation and Docking Studies of 1,3,4-Oxadiazole Fused Benzothiazole Derivatives for Anticancer Drugs

Volume:15   Issue:12
Pp: 1299-1307
Madala Subramanyam, Reddymasu Sreenivasulu, Rambabu Gundla, Mandava V.B. Rao and Koya Prabhakara Rao*
DOI: 10.2174/1570180815666180219165119

Synthesis and Antioxidant Evaluation of a New Class of Thienopyrimidine-rhodanine Hybrids

Volume:15   Issue:2
Pp: 118-126
Kerru Nagaraju , Venkata H.S.S. Bhaskaruni, Ravada Kishore , Suresh Maddila*, Parvesh Singh and Sreekantha B. Jonnalagadda
DOI: 10.2174/1570180814666170710161844

Biological Activities and Docking Studies on Novel Bis 1,4-DHPS Linked to Arene Core via Ether or Ester Linkage

Volume:15   Issue:10
Pp: 1036-1045
Nada S. Ibrahim, Magda F. Mohamed, Ahmed H. M. Elwahy* and Ismail A. Abdelhamid*
DOI: 10.2174/1570180815666180105162323

Novel Azole-Functionalited Flouroquinolone Hybrids: Design, Conventional and Microwave Irradiated Synthesis, Evaluation as Antibacterial and Antioxidant Agents

Volume:15   Issue:1
Pp: 46-64
Meltem Mentese, Neslihan Demirbas*, Arif Mermer, Serpil Demirci, Ahmet Demirbas and Faik Ahmet Ayaz
DOI: 10.2174/1570180814666170823163540

A Comprehensive Review on Recent Developments in the Field of Biological Applications of Potent Pyrazolines Derived from Chalcone Precursors

Volume:15   Issue:5
Pp: 516-574
Vinutha V. Salian, Badiadka Narayana*, Balladka K. Sarojini and Kullaiah Byrappa
DOI: 10.2174/1570180814666170703164221

Synthesis and Biological Evaluation of New Quinoline-Based Thiazolyl Hydrazone Derivatives as Potent Antifungal and Anticancer Agents

Volume:15   Issue:2
Pp: 193-202
Ali Erguc, Mehlika Dilek Altintop*, Ozlem Atli, Belgin Sever, Gokalp Iscan, Gozde Gormus and Ahmet Ozdemir
DOI: 10.2174/1570180814666171003145227

Synthesis, Characterization and Evaluation of Gemfibrozil-Stilbene Hybrid as Antioxidant Agent

Volume:15   Issue:11
Pp: 1230-1238
Rosa Amoroso, Lidia Leporini, Ivana Cacciatore, Lisa Marinelli, Alessandra Ammazzalorso, Isabella Bruno, Barbara De Filippis, Marialuigia Fantacuzzi, Cristina Maccallini, Luigi Menghini, Antonio Di Stefano and Letizia Giampietro*
DOI: 10.2174/1570180815666180321163246

Design, Synthesis, and Screening of Hybrid Benzothiazolyl-Oxadiazoles as Anticonvulsant Agents

Volume:15   Issue:4
Pp: 398-405
Sheikh Murtuja, Mohammad Shaquiquzzaman and Mohammad Amir*
DOI: 10.2174/1570180814666170526154914

Arginine- and Lysine-rich Peptides: Synthesis, Characterization and Antimicrobial Activity

Volume:15   Issue:3
Pp: 220-226
Adriano Mollica*, Giorgia Macedonio, Azzurra Stefanucci, Roberto Costante, Simone Carradori, Valentina Cataldi, Mara Di Giulio, Luigina Cellini, Romano Silvestri, Cesare Giordano, Anita Scipioni, Stefano Morosetti, Pasqualina Punzi and Sako Mirzaie
DOI: 10.2174/1570180814666170213161341

New 1,3-oxazolylphosphonium Salts as Potential Biocides: QSAR Study, Synthesis, Antibacterial Activity and Toxicity Evaluation

Volume:15   Issue:12
Pp: 1259-1267
Maria M. Trush*, Vasyl Kovalishyn, Alla D. Ocheretniuk, Larisa E. Kalashnikova, Volodymyr M. Prokopenko, Oleksandr V. Holovchenko, Oleksandr L. Kobzar, Volodymyr S. Brovarets and Larisa O. Metelytsia
DOI: 10.2174/1570180815666180219164334

6-Methoxy-3,4-dihydronaphthalenone Chalcone-like Derivatives as Potent Tyrosinase Inhibitors and Radical Scavengers

Volume:15   Issue:11
Pp: 1170-1179
Sara Ranjbar, Abdolhossein Akbari, Najmeh Edraki, Mahsima Khoshneviszadeh, Hajar Hemmatian, Omidreza Firuzi and Mehdi Khoshneviszadeh*
DOI: 10.2174/1570180815666180219155027

Microwave-assisted Synthesis and Antifungal Activity of Novel 1,2,4- Triazole Thioether Derivatives Containing Pyrimidine Moiety

Volume:15   Issue:4
Pp: 347-352
Meng Xu, Ya-Bo Zhu, Mei Wang, Ikhlas A. Khan, Xing-Hai Liu and Jian-Quan Weng*
DOI: 10.2174/1570180814666170602082440

Efficient Synthesis of Ibandronate in the Presence of an Ionic Liquid open access plus

Volume:15   Issue:7
Pp: 713-720
David Illes Nagy, Alajos Grun, Oliver Pavela, Sandor Garadnay, Istvan Greiner and Gyorgy Keglevich*
DOI: 10.2174/1570180814666171027160324

Synthesis and Assessment of Novel Anti-chlamydial Benzylidene Acylhydrazides Derivatives

Volume:15   Issue:1
Pp: 31-36
Xiaofeng Bao, Ying Xue, Chao Xia, Yin Lu, Ningjing Yang and Yu Zhao*
DOI: 10.2174/1570180814666170526170227

Synthesis and Herbicidal Evaluation of Aryloxyphenoxypropionate Derivatives Containing Purine Moiety

Volume:15   Issue:1
Pp: 15-20
Jianjun Shi, Guihua Ren, Zhimeng Dai, Ningjie Wu, Jianquan Weng, Tianming Xu, Xinghai Liu* and Chengxia Tan*
DOI: 10.2174/1570180814666170505123102

Herbal Medicines: Application of a Sequential Voltammetric Procedure to the Determination of Mercury, Copper, Lead, Cadmium and Zinc at Trace Level

Volume:15   Issue:3
Pp: 270-280
Dora Melucci, Marcello Locatelli, Francesco De Laurentiis, Gokhan Zengin and Clinio Locatelli*
DOI: 10.2174/1570180814666170412124634

Design and Synthesis of Novel 1,3,4-Oxadiazole Derivatives Bearing Azo Moiety as Biologically Significant Scaffolds

Volume:15   Issue:12
Pp: 1346-1355
Bilal Ahmad Khan*, Safeena Zafar, Ehsan Ullah Mughal*, Muhammad Naeem Ahmed, Syeda Shamila Hamdani, Tashfeen Akhtar, Ihsan-ul-Haq, Amina Sadiq and Khalid Mohammed Khan
DOI: 10.2174/1570180815666180326152204