Letters in Drug Design & Discovery

Editor-in-Chief
K. Kuca
University of Hradec Kralove
Hradec Kralove
Czech Republic

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Most Cited Article

Microwave Assisted Synthesis and Antifungal Activity of Some Novel Thioethers Containing 1,2,4-triazolo[4,3-a] pyridine Moiety

Volume:13   Issue:6
Pp: 521-525
Zhi-Wen Zhai, Yan-Xia Shi, Ming-Yan Yang, Wen Zhao, Zhao-Hui Sun, Jian-Quan Weng, Cheng-Xia Tan, Xing-Hai Liu, Bao-Ju Li and Yong-Gang Zhang
DOI: 10.2174/157018081306160618181757

Synthesis of Mannich Bases by Two Different Methods and Evaluation of their Acetylcholine Esterase and Carbonic Anhydrase Inhibitory Activities

Volume:14   Issue:5
Pp: 573-580
Halise I. Gul*, Alkan Demirtas, Gokbay Ucar, Parham Taslimi and İlhami Gulcin
DOI: 10.2174/1570180814666161128120612

Synthesis and Nematocidal Activity of Novel Pyrazole Carboxamide Derivatives Against Meloidogyne incognita

Volume:14   Issue:3
Pp: 323-329
Wen Zhao, Zhong-Hua Shen, Jia-Hua Xing, Tian-Ming Xu, Wei-Li Peng and Xing-Hai Liu
DOI: 10.2174/1570180813666160930164327

Recent Developments in the Synthesis and Applications of Anticancer Amonafide Derivatives. A Mini Review promotion: free to download

Volume:13   Issue:1
Pp: 47-63
Gary Gellerman
DOI: 10.2174/1570180812666150529205049

Design, Synthesis and Biological Evaluation of 4-(Imidazolylmethyl)-2- Aryl-Quinoline Derivatives as Aromatase Inhibitors and Anti-breast Cancer Agents promotion: free to download

Volume:13   Issue:1
Pp: 89-97
Razieh Ghodsi, Ebrahim Azizi, Maria Grazia Ferlin, Vincenzo Pezzi and Afshin Zarghi
DOI: 10.2174/1570180812666150611185605

Flexibility in the Molecular Design of Acetylcholinesterase Reactivators: Probing Representative Conformations by Chemometric Techniques and Docking/QM Calculations

Volume:13   Issue:5
Pp: 360-371
Willian E.A. de Lima, Ander F. Pereira, Alexandre A. de Castro, Elaine F.F. da Cunha and Teodorico C. Ramalho
DOI: 10.2174/1570180812666150918191550

Synthesis of Novel C3-Linked β-Carboline-Pyridine Derivatives Employing Khronke Reaction: DNA-binding Ability and Molecular Modeling Studies

Volume:13   Issue:4
Pp: 335-342
Nagula Shankaraiah, Pankaj Sharma, Srinivas Pedapati, Shalini Nekkanti, Vunnam Srinivasulu, Niggula Praveen Kumar and Ahmed Kamal
DOI: 10.2174/157018081304160303180050

Synthesis, Biological Evaluation and Molecular Docking Studies of 4Hbenzo[ h]chromenes, 7H-benzo[h]chromeno[2,3-d]pyrimidines as Antitumor Agents promotion: free to download

Volume:13   Issue:1
Pp: 77-88
Ahmed H. Halawa, Ahmed M. Fouda, Al-Anood M. Al-Dies and Ahmed M. El-Agrody
DOI: 10.2174/1570180812666150611185830

Prediction of Caco-2 Cell Permeability Using Bilinear Indices and Multiple Linear Regression

Volume:13   Issue:2
Pp: 161-169
Huong Le-Thi-Thu, Yudith Canizares-Carmenate, Yovani Marrero-Ponce, Francisco Torrens and Juan A. Castillo-Garit
DOI: 10.2174/1570180812666150630183511

Synthesis and Antimicrobial Evaluation of Amphipathic Peptide Models

Volume:13   Issue:7
Pp: 715-724
Marianna Sakka, Alexandra Balliou, Asimina Marianou, Dimitris Krikorian, Margarita Tsirogianni, Artemis Tsiligianni, Katerina Vartzeli, Anna-Irini Koukkou, Maria Sakarellos-Daitsiotis and Eugenia Panou- Pomonis
DOI: 10.2174/1570180813666160616122410

Efficient Synthesis of Pamidronic Acid Using an Ionic Liquid Additive open access plus

Volume:13   Issue:6
Pp: 475-478
Alajos Grun, Dávid Illés Nagy, Sándor Garadnay, István Greiner and Gyorgy Keglevich
DOI: 10.2174/1570180812666151022221805

Design, Synthesis and Mode of Action of Some New 2-(4'-aminophenyl) benzothiazole Derivatives as Potent Antimicrobial Agents

Volume:13   Issue:5
Pp: 429-437
Meenakshi Singh, Sudhir Kumar Singh, Mayank Gangwar, Satheeshkumar Sellamuthu, Gopal Nath and Sushil K. Singh
DOI: 10.2174/1570180812666150821003220

Antinociceptive Activities of Some 4,5-Dihydro-1H-Pyrazole Derivatives: Involvement of Central and Peripheral Pathways

Volume:13   Issue:5
Pp: 411-417
Özgür Devrim Can, Feyza Alyu, Nazlı Turan and Ahmet Özdemir
DOI: 10.2174/1570180812666150819003950

Design and Synthesis of Novel Spiro-Piperidinyl Pyrazolone Derivatives and Their Potential Antiviral Activity

Volume:13   Issue:2
Pp: 149-160
Rajagopalan Srinivasan, Badiadka Narayana, Balladka Kunhanna Sarojini, Veerakyathappa Bhanuprakash, Chenna Govindaraju Darshan Raj and Prakash S. Nayak
DOI: 10.2174/1570180812666150630182740

Evaluation of Serine Protease Inhibitors as Potent FVIIa-sTF Inhibitors in the Blood Coagulation Cascade promotion: free to download

Volume:13   Issue:1
Pp: 3-23
Andrea Roxanne J. Anas and Ken-ichi Harada
DOI: 10.2174/1570180812666150608230214

Synthesis, Molecular Docking Study, and Cytotoxic Activity of 1,3,5-triaryl Pyrazole Derivatives

Volume:13   Issue:2
Pp: 121-128
Maryam Ghasemi, Sajad Ghadbeighi, Amirali Amirhamzeh, Seyed AbbasTabatabai, Seyed Nasser Ostad, Abbas Shafiee and Mohsen Amini
DOI: 10.2174/1570180812666150722235902

Accumulation Effects of 3-N-Benzyloxycarbonyl-β-aminobutyric Salicylate on the Alkaloids in Catharanthus roseus Cells

Volume:13   Issue:2
Pp: 117-120
Er-Bing Yang, Yong Wang, Hong-Jun Zang, Zheng-Ming Li and Xing-Hai Liu
DOI: 10.2174/1570180812666150723001034

A Series of 2,4(1H,3H)-Quinazolinedione Derivatives: Synthesis and Biological Evaluation as Potential Anticancer Agents promotion: free to download

Volume:13   Issue:1
Pp: 64-76
Hulya Akgun, Demet Us Yilmaz, Rengul Cetin Atalay and Damla Gozen
DOI: 10.2174/1570180812666150529204909

Development of Energy-based Pharmacophore Model and Stepwise Virtual Screening of LRRK2 Inhibitors Through Molecular Dynamics and Mechanics promotion: free to download

Volume:13   Issue:1
Pp: 24-32
Sagar S. Bhayye, Kunal Roy and Achintya Saha
DOI: 10.2174/1570180812666150611185331

Microwave Assisted Synthesis and Antifungal Activity of Some Novel Hydrazones Containing Pyridine Moiety

Volume:13   Issue:4
Pp: 324-328
Li-Jing Min, Yan-Xia Shi, Ming-Yan Yang, Zhi-Wen Zhai, Jian-Quan Weng, Cheng-Xia Tan, Xing-Hai Liu, Bao-Ju Li and Yong-Gang Zhang
DOI: 10.2174/1570180812666151003002140