Letters in Drug Design & Discovery

Editor-in-Chief
K. Kuca
University of Hradec Kralove
Hradec Kralove
Czech Republic

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Open Access Articles

Challenges in the Discovery and Optimization of mGlu2/4 Heterodimer Positive Allosteric Modulators open Access plus

Volume: 16   Issue: 12
Pp: 1387-1394
Mark Gallant Fulton, Matthew Thomas Loch, Caroline Anne Cuoco, Alice Lambert Rodriguez, Emily Days, Paige Newton Vinson, Krystian Andrezej Kozek, Charles David Weaver, Anna Louise Blobaum, Peter Jeffrey Conn, Colleen Marie Niswender* and Craig William Lindsley*
DOI:10.2174/1570180815666181017131349

Synthesis of Phenyl- and Pyridyl-substituted Benzyloxybenzaldehydes by Suzuki-Miyaura Coupling Reactions open Access plus

Volume: 16   Issue: 11
Pp: 1248-1257
Hedvig Bölcskei*, Andrea Német-Hanzelik, Zsófia Dubrovay, Viktor Háda and György Keglevich
DOI:10.2174/1570180816666181106123809

Effects of Dietary Intake and Supplementation of Fatty Acids on Cardiometabolic Disorders in Humans: a Lesson from a Large Number of Meta-Analyses open Access plus

Volume: 16   Issue: 10
Pp: 1138-1145
Sho-ichi Yamagishi* and Takanori Matsui
DOI:10.2174/1570180816666181107113148

Benzo[d]imidazol-5-yl)-5-(substituted)-1,3,4-Oxadiazoles: Synthesis, Anticancer, Antimicrobial and In Silico Studies open Access plus

Volume: 16   Issue: 9
Pp: 994-1005
Naveen Kumar, Swamy Sreenivasa*, Bhuvanesh Sukhlal Kalal, Vasantha Kumar, Bantwal Shivarama Holla, Vinitha Ramanath Pai, Nadigar Revansiddappa Mohan and Shivaraj Govindaiah
DOI:10.2174/1570180816666181220123924

The Structure of MT189-Tubulin Complex Provides Insights into Drug Design open Access plus

Volume: 16   Issue: 9
Pp: 1069-1073
Zhongping Li, Lingling Ma, Chengyong Wu, Tao Meng, Lanping Ma, Wenyue Zheng, Yamei Yu*, Qiang Chen*, Jinliang Yang and Jingkang Shen
DOI:10.2174/1570180816666181122122655

Synthesis and Evaluation of in vitro Antiplatelet Aggregation Activities of 2-Methoxy-5-Aminobenzamides open Access plus

Volume: 16   Issue: 9
Pp: 1040-1050
Lili Liu, Xiujie Liu*, Guangling Chen and Kai Qiu
DOI:10.2174/1570180816666181128105044

Synthesis and Biological Evaluation of Some Pyrazole Derivatives, Containing (Thio) Semicarbazide, as Dual Anti-Inflammatory Antimicrobial Agents open Access plus

Volume: 16   Issue: 9
Pp: 1020-1030
Zhaochang Liang, Yuping Huang, Shiben Wang and Xianqing Deng*
DOI:10.2174/1570180816666190325163117

In Vitro and In Vivo Profiles and Characterization of Insulin Nanocarriers Based in Flexible Liposomes Designed for Oral Administration open Access plus

Volume: 16   Issue: 8
Pp: 948-960
Sara Melisa Arciniegas Ruiz, María Josefa Bernad Bernad, Raquel Lopez Arellano, Roberto Diaz Torres, Sara Del Carmen Caballero Chacón and Dinorah Vargas Estrada*
DOI:10.2174/1570180816666190110112929

Design and Synthesis of Novel Thiosemicarbazones as Potent Anti-breast Cancer Agents open Access plus

Volume: 16   Issue: 4
Pp: 446-452
Mashooq Ahmad Bhat*, M. Al-Tahhan, Mohamed A. Al-Omar, Ahmed M. Naglah and Abdullah Al-Dhfyan
DOI:10.2174/1570180815666181008100944

A Study on the Synthesis of Risedronic Acid: The Role of an Ionic Liquid Additive open Access plus

Volume: 16   Issue: 3
Pp: 238-244
Dávid Illés Nagy, Alajos Grün, Júlia Sinkovicz, Sándor Garadnay, István Greiner and György Keglevich*
DOI:10.2174/1570180815666180626122630

Synthesis and Biological Evaluation of Some Novel Thiophene-bearing Quinazoline Derivatives as EGFR Inhibitors open Access plus

Volume: 16   Issue: 2
Pp: 102-110
Min Zou, Bo Jin, Yanrong Liu, Huiping Chen, Zhuangli Zhang, Changzheng Zhang, Zhihong Zhao and Liyun Zheng*
DOI:10.2174/1570180815666180803125935

A Series of Furan-Based Hydrazones: Design, Synthesis, and Evaluation of Antimicrobial Activity, Cytotoxicity and Genotoxicity open Access plus

Volume: 16  
Pp: 1-11
Mehlika Dilek Altıntop*, Belgin Sever, Özlem Atlı Eklioğlu, Merve Baysal, Rasime Demirel and Ahmet Özdemir
DOI:10.2174/1570180816666190325163948

Efficient Synthesis of Ibandronate in the Presence of an Ionic Liquid open Access plus

Volume: 15   Issue: 7
Pp: 713-720
David Illes Nagy, Alajos Grun, Oliver Pavela, Sandor Garadnay, Istvan Greiner and Gyorgy Keglevich*
DOI:10.2174/1570180814666171027160324

L-carnitine Supplementation Improves Self-rating Depression Scale Scores in Uremic Male Patients Undergoing Hemodialysis open Access plus

Volume: 14   Issue: 6
Pp: 737-742
Kyoko Tashiro, Yusuke Kaida, Sho-ichi Yamagishi, Hideharu Tanaka, Miyuki Yokoro, Junko Yano, Kazuko Sakai, Yuka Kurokawa, Kensei Taguchi, Yosuke Nakayama, Takahiro Inokuchi and Kei Fukami*
DOI:10.2174/1570180814666170216102632

The Synthesis of (Iodobenzyl)oxybenzaldehydes, Useful Intermediates for Biologically Active Targets open Access plus

Volume: 14   Issue: 2
Pp: 233-239
Hedvig Bölcskei, Andrea Német-Hanzelik, István Greiner, Zsófia Dubrovay, Viktor Háda and György Keglevich
DOI:10.2174/1570180813666160804142245

In Vitro and In Vivo Investigations into the Carbene Gold Chloride and Thioglucoside Anticancer Drug Candidates NHC-AuCl and NHC-AuSR open Access plus

Volume: 14   Issue: 2
Pp: 125-134
Wolfgang Walther, Oyinlola Dada, Cillian O’Beirne, Ingo Ott, Goar Sánchez-Sanz, Claudia Schmidt, Carsta Werner, Xiangming Zhu and Matthias Tacke
DOI:10.2174/1570180813666160826100158

Efficient Synthesis of Pamidronic Acid Using an Ionic Liquid Additive open Access plus

Volume: 13   Issue: 6
Pp: 475-478
Alajos Grun, Dávid Illés Nagy, Sándor Garadnay, István Greiner and Gyorgy Keglevich
DOI:10.2174/1570180812666151022221805

Potent and Orally Bioavailable Antiplatelet Agent, PLD-301, with the Potential of Overcoming Clopidogrel Resistance open Access plus

Volume: 13   Issue: 3
Pp: 250-254
Jingyu Chen and Michael Zhiyan Wang
DOI:10.2174/1570180812666150730221941

The Synthesis of Risedronic Acid and Alendronate Applying Phosphorus Oxychloride and Phosphorous Acid in Methanesulfonic Acid open Access plus

Volume: 12   Issue: 4
Pp: 253-258
Alajos Grun, Rita Kovacs, Sandor Garadnay, Istvan Greiner and Gyorgy Keglevich
DOI:10.2174/1570180811666141010220427

4-Substituted-2-Methoxyphenol: Suitable Building Block to Prepare New Bioactive Natural-like Hydroxylated Biphenyls open Access plus

Volume: 12   Issue: 2
Pp: 131-139
Maria Antonietta Dettori, Davide Fabbri, Marina Pisano, Carla Rozzo, Giuseppe Palmieri, Alessandro Dessi, Roberto Dallocchio and Giovanna Delogu
DOI:10.2174/1570180811666140915222343

Design and Synthesis of New Dual Binding Site Cholinesterase Inhibitors: in vitro Inhibition Studies with in silico Docking open Access plus

Volume: 11   Issue: 3
Pp: 331-338
Muhammad Yar, Marek Bajda, Rana Atif Mehmood, Lala Rukh Sidra, Nisar Ullah, Lubna Shahzadi, Muhammad Ashraf, Tayaba Ismail, Sohail Anjum Shahzad, Zulfiqar Ali Khan, Syed Ali Raza Naqvi and Nasir Mahmood
DOI:10.2174/15701808113106660078

Optimized Synthesis of Etidronate open Access plus

Volume: 10   Issue: 8
Pp: 733-737
Rita Kovacs, David Illes Nagy, Alajos Grün, Gyorgy Tibor Balogh, Sandor Garadnay, Istvan Greiner and Gyorgy Keglevich
DOI:10.2174/15701808113109990026

Synthesis and Biological Evaluation of Spiro-δ-lactones as Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 2 (17β-HSD2) open Access plus

Volume: 8   Issue: 5
Pp: 406-421
Kuiying Xu, Marie Wetzel, Rolf W. Hartmann and Sandrine Marchais-Oberwinkler
DOI:10.2174/157018011795514230

Phenylpyazoleanilides as Potent Inhibitor of IL-15 Dependent T Cell Proliferation. Part 2: Discovery of a New Drug Candidate, Y-320 open Access plus

Volume: 5   Issue: 4
Pp: 292-296
Hiroyuki Ushio, Seigo Ishibuchi, Kunitomo Adachi, Kouichi Oshita and Kenji Chiba
DOI:10.2174/157018008784619861

Selective Androgen Receptor Modulators Antagonize Apolipoprotein E4-Induced Cognitive Impairments open Access plus

Volume: 5   Issue: 4
Pp: 271-276
Summer Acevedo, Luis Gardell, Stefania Risso Bradley, Fabrice Piu and Jacob Raber
DOI:10.2174/157018008784619898

Phenylpyazoleanilides as a Potent Inhibitor of IL-15 Dependent T Cell Proliferation. Part 1: A New Class of Orally Available Immunomodulators open Access plus

Volume: 5   Issue: 2
Pp: 111-115
Hiroyuki Ushio, Seigo Ishibuchi, Kunitomo Adachi, Kouichi Oshita and Kenji Chiba
DOI:10.2174/157018008783928427