Abstract
Gabapentin is an antiepileptic drug, which decreases neuronal excitability and may act by increasing the availability of gamma-aminobutyric acid or by inhibiting Ca2+ channels. It has safe pharmacokinetic and side effect profiles. Not surprisingly, it has been tested as a treatment in a number of psychiatric conditions. The most robust evidence exists for it as an efficacious treatment in both social phobia and panic disorder. However, the extant literature indicates that it also holds promise in the treatment of other anxiety disorders, alcohol and cocaine dependence, nonrefractory bipolar disorder, as well as in behavioral agitation. Further, controlled, investigations of gabapentins effectiveness in these disorders / conditions merit due consideration, especially given their associated morbidity and lost productivity.
Keywords: gabapentin, pharmacology, pregnancy, lactation, psychiatric disorder
Current Neuropharmacology
Title: Pharmacology and Therapeutics of Gabapentin in the Treatment of Psychiatric Disorders; Present and Future Perspectives
Volume: 1 Issue: 3
Author(s): J. L. Megna, M. M. Iqbal and A. Aneja
Affiliation:
Keywords: gabapentin, pharmacology, pregnancy, lactation, psychiatric disorder
Abstract: Gabapentin is an antiepileptic drug, which decreases neuronal excitability and may act by increasing the availability of gamma-aminobutyric acid or by inhibiting Ca2+ channels. It has safe pharmacokinetic and side effect profiles. Not surprisingly, it has been tested as a treatment in a number of psychiatric conditions. The most robust evidence exists for it as an efficacious treatment in both social phobia and panic disorder. However, the extant literature indicates that it also holds promise in the treatment of other anxiety disorders, alcohol and cocaine dependence, nonrefractory bipolar disorder, as well as in behavioral agitation. Further, controlled, investigations of gabapentins effectiveness in these disorders / conditions merit due consideration, especially given their associated morbidity and lost productivity.
Export Options
About this article
Cite this article as:
Megna L. J., Iqbal M. M. and Aneja A., Pharmacology and Therapeutics of Gabapentin in the Treatment of Psychiatric Disorders; Present and Future Perspectives, Current Neuropharmacology 2003; 1 (3) . https://dx.doi.org/10.2174/1570159033477125
DOI https://dx.doi.org/10.2174/1570159033477125 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications
Current Neuropharmacology Crisis and the Neurobiology Involved in the Development of Consequent Mental Illness
Current Psychiatry Reviews Simple and Fast Gas-chromatography Mass Spectrometry Assay to Assess Delta 9-Tetrahydrocannabinol and Cannabidiol in Dogs Treated with Medical Cannabis for Canine Epilepsy
Current Pharmaceutical Biotechnology Delirium Secondary to Lamotrigine Toxicity
Current Drug Safety Molecular Imaging at Tohoku University: From Cancer to Neuroreceptors
Current Medical Imaging Convection-Enhanced Delivery: Neurosurgical Issues
Current Drug Targets Patent Selections:
Recent Patents on Biomedical Engineering (Discontinued) Commentary (Research Highlights: Transcranial Drug Delivery for Neurological Disorders)
CNS & Neurological Disorders - Drug Targets Overview of Chemistry and Therapeutic Potential of Non-Nitrogen Heterocyclics as Anticonvulsant Agents
Current Neuropharmacology Importance of P-gp PET Imaging in Pharmacology
Current Pharmaceutical Design Transdermal Drug Delivery: A Step towards Treatment of Cancer
Recent Patents on Anti-Cancer Drug Discovery Nutraceuticals for Protection and Healing of Gastrointestinal Mucosa
Current Medicinal Chemistry Poly(ADP-Ribose)Polymerase 1 (PARP-1) Activation and Ca<sup>2+</sup> Permeable α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid (AMPA) Channels in Post-Ischemic Brain Damage: New Therapeutic Opportunities?
CNS & Neurological Disorders - Drug Targets Allopregnanolone Increases the Number of Dopaminergic Neurons in Substantia Nigra of a Triple Transgenic Mouse Model of Alzheimer’s Disease
Current Alzheimer Research The Interaction Potential of Retigabine (Ezogabine) with Other Antiepileptic Drugs
Current Clinical Pharmacology Genetics and Mitochondrial Abnormalities in Autism Spectrum Disorders:A Review
Current Genomics Mitochondrial Permeability Transition Pore as a Suitable Targ e t for Neuroprotective Agents Against Alzheimer’s Disease
CNS & Neurological Disorders - Drug Targets Design, Synthesis and Evaluation of the Antidepressant and Anticonvulsant Activities of Triazole-Containing Benzo[d]oxazoles
CNS & Neurological Disorders - Drug Targets Zebrafish as a Platform for Studies on Seizures and Epilepsy
Current Psychopharmacology Golgi Localization of Glycosyltransferases Involved in Ganglioside Biosynthesis
Current Drug Targets