Function and Regulation of Tumor Necrosis Factor Receptor Type 2

Title: Function and Regulation of Tumor Necrosis Factor Receptor Type 2

Volume: 11 Issue: 16

Author(s): I. Carpentier, B. Coornaert and R. Beyaert

Affiliation:

Keywords: tumor necrosis factor receptor (tnf-r), signal transduction, apoptosis, inflammation, cd120b, disease, polymorphisms

Abstract: TNF is a major proinflammatory cytokine, which exerts its effects through two different receptors known as TNF-R1 and TNF-R2. Whereas TNF-R1 induced signaling pathways have been very well characterized during the past years, TNF-R2 has been much less well studied. Nevertheless, the function of TNF-R2 should not be underestimated, the more because this receptor shows a much more restricted but inducible expression. Several inflammatory diseases and cancers show upregulated levels of soluble TNF-R2 or are associated with TNF-R2 polymorphisms, implicating an important role for TNF-R2 as a therapeutic target. Here we will review the mechanisms that regulate TNF-R2 expression, as well as discuss TNF-R2 induced signal transduction and cross-talk with TNF-R1.

Cite this article as:

Carpentier I., Coornaert B. and Beyaert R., Function and Regulation of Tumor Necrosis Factor Receptor Type 2, Current Medicinal Chemistry 2004; 11 (16) . https://dx.doi.org/10.2174/0929867043364694