Abstract
In a variety of cell types, activation of phospholipase C-linked receptors results in the generation of intracellular Ca2+ signals comprised of components of both intracellular Ca2+ release, and enhanced entry of Ca2+ across the plasma membrane. This entry of Ca2+ occurs by either of two general mechanisms: the release of stored Ca2+ can activate, by an unknown mechanism, storeoperated channels in the plasma membrane, a process known as capacitative calcium entry. Alternatively, second messengers generated at the plasma membrane can activate Ca2+ channels more directly, a non-capacitative calcium entry process. This review summarizes current knowledge of the underlying signaling mechanisms and the nature of the channel molecules responsible for these two general categories of regulated Ca2+ entry.
Keywords: phospholipase c, phospholipase c-linked receptors, intracellular
Current Molecular Medicine
Title: Mechanisms of Phospholipase C-Regulated Calcium Entry
Volume: 4 Issue: 3
Author(s): Gary S. Bird, Omar Aziz, Jean-Philippe Lievremont, Barbara J. Wedel, Mohamed Trebak, Guillermo Vazquez and James W. Putney Jr.
Affiliation:
Keywords: phospholipase c, phospholipase c-linked receptors, intracellular
Abstract: In a variety of cell types, activation of phospholipase C-linked receptors results in the generation of intracellular Ca2+ signals comprised of components of both intracellular Ca2+ release, and enhanced entry of Ca2+ across the plasma membrane. This entry of Ca2+ occurs by either of two general mechanisms: the release of stored Ca2+ can activate, by an unknown mechanism, storeoperated channels in the plasma membrane, a process known as capacitative calcium entry. Alternatively, second messengers generated at the plasma membrane can activate Ca2+ channels more directly, a non-capacitative calcium entry process. This review summarizes current knowledge of the underlying signaling mechanisms and the nature of the channel molecules responsible for these two general categories of regulated Ca2+ entry.
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Cite this article as:
Bird S. Gary, Aziz Omar, Lievremont Jean-Philippe, Wedel J. Barbara, Trebak Mohamed, Vazquez Guillermo and Putney Jr. W. James, Mechanisms of Phospholipase C-Regulated Calcium Entry, Current Molecular Medicine 2004; 4 (3) . https://dx.doi.org/10.2174/1566524043360681
DOI https://dx.doi.org/10.2174/1566524043360681 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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