Abstract
It is generally believed that multiple Ca2+ stores are present in cells, a notion that has now been made substantive by the discovery of multiple Ca2+ mobilizing messengers. Cyclic ADP-ribose (cADPR) and nicotinic acid dinucleotide phosphate (NAADP) are two such messengers that are derived from NAD and NADP, respectively. A wide variety of cells, from plants to mammals, including human, have been shown to be responsive to these two novel Ca2+ messengers. Not only are their structures and mechanisms of action different, their targeted Ca2+ stores are also distinct and separable. This article explores the implications of the multiplicity of Ca2+ stores in cellular signaling. Special emphasis will be put on the recent progress in the understanding of the physiological functions of NAADP.
Keywords: cyclic adp-ribose (cadpr), naadp, adp-ribosyl cyclase, cd38, mobilization
Current Molecular Medicine
Title: Multiplicity of Ca2+ Messengers and Ca2+ Stores: A Perspective from Cyclic ADP-Ribose and NAADP
Volume: 4 Issue: 3
Author(s): Hon Cheung Lee
Affiliation:
Keywords: cyclic adp-ribose (cadpr), naadp, adp-ribosyl cyclase, cd38, mobilization
Abstract: It is generally believed that multiple Ca2+ stores are present in cells, a notion that has now been made substantive by the discovery of multiple Ca2+ mobilizing messengers. Cyclic ADP-ribose (cADPR) and nicotinic acid dinucleotide phosphate (NAADP) are two such messengers that are derived from NAD and NADP, respectively. A wide variety of cells, from plants to mammals, including human, have been shown to be responsive to these two novel Ca2+ messengers. Not only are their structures and mechanisms of action different, their targeted Ca2+ stores are also distinct and separable. This article explores the implications of the multiplicity of Ca2+ stores in cellular signaling. Special emphasis will be put on the recent progress in the understanding of the physiological functions of NAADP.
Export Options
About this article
Cite this article as:
Lee Cheung Hon, Multiplicity of Ca2+ Messengers and Ca2+ Stores: A Perspective from Cyclic ADP-Ribose and NAADP, Current Molecular Medicine 2004; 4 (3) . https://dx.doi.org/10.2174/1566524043360753
DOI https://dx.doi.org/10.2174/1566524043360753 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Signaling Pathways Involved in Antidepressant-Induced Cell Proliferation and Synaptic Plasticity
Current Pharmaceutical Design Recent Innovations in Off-Road Intelligent Vehicles: In-Field Automatic Navigation
Recent Patents on Mechanical Engineering Progress in Clinical, Pharmacological, Chemical and Structural Biological Studies of Huperzine A: A Drug of Traditional Chinese Medicine Origin for the Treatment of Alzheimers Disease
Current Medicinal Chemistry Synthesis and Anxiolytic Activity of Some Novel 5-oxo-1, 4-oxazepine Derivatives
Letters in Drug Design & Discovery Bariatric Surgery: Indications, Safety and Efficacy
Current Pharmaceutical Design Postmenopausal Hypertension: Insights from Rat Models
Current Hypertension Reviews The Role of Genes Involved in Neuroplasticity and Neurogenesis in the Observation of a Gene-Environment Interaction (GxE) in Schizophrenia
Current Molecular Medicine Editorial [ Hot Topic:Reproductive Issues for Women with Sclizophrenia(Guest Editors: Mary V. Seeman and Laura J. Miller) ]
Current Women`s Health Reviews Pro-apoptotic Activity of BH3-only Proteins and BH3 Mimetics: from Theory to Potential Cancer Therapy
Anti-Cancer Agents in Medicinal Chemistry Adolescence and Borderline Behavior - Between Personality Development and Personality Disorder
Adolescent Psychiatry An Introduction to Obesity and Dementia
Current Alzheimer Research Oxidative Stress in the Hypothalamus: the Importance of Calcium Signaling and Mitochondrial ROS in Body Weight Regulation
Current Neuropharmacology Do Epigenetic Pathways Initiate Late Onset Alzheimer Disease (LOAD): Towards a New Paradigm
Current Alzheimer Research Diagnostic Value of the Early Heart-to-Mediastinum Count Ratio in Cardiac 123I-mIBG Imaging for Parkinson's Disease
Current Radiopharmaceuticals Roles of Biogenic Amines in Intestinal Signaling
Current Protein & Peptide Science Relationship Between Oxidative Stress, Tau Level and Antioxidant Mechanisms of the KEAP-1/NRF-2/HO-1 in Children with Hydrocephalus
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Editorial [Hot Topic: Depression (Part 2) (Guest Editors: Ronald S. Duman and John H. Kehne)]
CNS & Neurological Disorders - Drug Targets Transformation of UPLC-MS Data Overcomes Extreme Variability in Urine Concentration and Metabolite Fold Change
Current Metabolomics Acknowledgements
Current Neuropharmacology Methylene Blue Inhibits the Function of α7-Nicotinic Acetylcholine Receptors
CNS & Neurological Disorders - Drug Targets