Abstract
The enzymes involved in the replication of the Hepatitis C Virus (HCV) have been some of the most intensely studied proteins in recent history because they are targets for rational drug design. HCV is an established and growing menace to human health that is without a current vaccine or a widely affordable and effective treatment. Traditional antiviral screening is difficult with HCV because of the lack of a convenient animal model or tissue culture system. Consequently, two viral replicative proteins have been intensely studied as drug targets: the NS3 protein, which possesses serine protease, ATPase, and helicase activities, and the NS5B RNA-dependent RNA polymerase. Structural and mechanistic studies of the HCV replicative proteins have not yet led to antiviral HCV drugs. However, new insights have been gained into the mechanisms of actions of the enzymes comprising the viral replicase. This review discusses recent advances in understanding the HCV NS5B RNA-dependent RNA polymerase and the NS3 helicase mechanisms and suggests how this new information could be exploited for the potential development of future antiviral agents.
Keywords: Hepatitis C Virus Replicase, RNA-dependent, antiviral, HCV replicative proteins
Current Organic Chemistry
Title: The Hepatitis C Virus Replicase: Insights into RNA-dependent RNA Replication and Prospects for Rational Drug Design
Volume: 8 Issue: 3
Author(s): David N. Frick
Affiliation:
Keywords: Hepatitis C Virus Replicase, RNA-dependent, antiviral, HCV replicative proteins
Abstract: The enzymes involved in the replication of the Hepatitis C Virus (HCV) have been some of the most intensely studied proteins in recent history because they are targets for rational drug design. HCV is an established and growing menace to human health that is without a current vaccine or a widely affordable and effective treatment. Traditional antiviral screening is difficult with HCV because of the lack of a convenient animal model or tissue culture system. Consequently, two viral replicative proteins have been intensely studied as drug targets: the NS3 protein, which possesses serine protease, ATPase, and helicase activities, and the NS5B RNA-dependent RNA polymerase. Structural and mechanistic studies of the HCV replicative proteins have not yet led to antiviral HCV drugs. However, new insights have been gained into the mechanisms of actions of the enzymes comprising the viral replicase. This review discusses recent advances in understanding the HCV NS5B RNA-dependent RNA polymerase and the NS3 helicase mechanisms and suggests how this new information could be exploited for the potential development of future antiviral agents.
Export Options
About this article
Cite this article as:
Frick N. David, The Hepatitis C Virus Replicase: Insights into RNA-dependent RNA Replication and Prospects for Rational Drug Design, Current Organic Chemistry 2004; 8 (3) . https://dx.doi.org/10.2174/1385272043485963
DOI https://dx.doi.org/10.2174/1385272043485963 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Potential Disease Targets for Drugs that Disrupt Protein - Protein Interactions of Grb2 and Crk Family Adaptors
Current Pharmaceutical Design Dual-Specificity MAP Kinase Phosphatases as Targets of Cancer Treatment
Anti-Cancer Agents in Medicinal Chemistry A Review on Screening Models for Potential Therapeutic Candidates and Targets Against SARS-CoV-2
Current Drug Targets Alkaloid-Metal Based Anticancer Agents
Current Topics in Medicinal Chemistry MicroRNA-203: Tumor Suppression and Beyond
MicroRNA ROCK Inhibitors as Emerging Therapeutic Candidates for Sarcomas
Current Cancer Drug Targets Meet Our Editorial Board Member
Current Protein & Peptide Science The Roles of Chromatin Remodeling Proteins in Cancer
Current Protein & Peptide Science The Possible Involvement of Glycogen Synthase Kinase-3 (GSK-3) in Diabetes, Cancer and Central Nervous System Diseases
Current Pharmaceutical Design Strategies Targeting DNA Topoisomerase I in Cancer Chemotherapy: Camptothecins, Nanocarriers for Camptothecins, Organic Non-Camptothecin Compounds and Metal Complexes
Current Drug Targets Molecular Pathways and Related Target Therapies in Liver Carcinoma
Current Pharmaceutical Design Possibilities of Two-Dimensional Gel Electrophoresis in the Understanding of Human Disease
Current Proteomics Overview of Cantharidin and its Analogues
Current Medicinal Chemistry Recent Development in the Synthesis of Eco-Friendly Polymeric Antioxidants
Current Organic Chemistry Exploiting Innate γδ T Lymphocytes for Tumor Immunotherapy
Recent Patents on Biomarkers Chemical Metabolic Inhibitors for the Treatment of Blood-Borne Cancers
Anti-Cancer Agents in Medicinal Chemistry Editorial [ Enediynes and Related Structures in Medicinal and Biorganic Chemistry Guest Editor: Ajoy Basak ]
Current Topics in Medicinal Chemistry Edelfosine in Membrane Environment - the Langmuir Monolayer Studies
Anti-Cancer Agents in Medicinal Chemistry Characterisation of Small Supernumerary Marker Chromosomes (sSMC) in Human
Current Genomics Ovarian Toxicity: From Environmental Exposure to Chemotherapy
Current Pharmaceutical Design