Abstract
Drugs exert their functions mainly by affecting proteins. Therefore, it seems straightforward to focus on proteins in order to investigate drug effects. Unfortunately, proteins are of very high complexity, rendering it much more difficult to screen for protein alterations as compared to gene regulation. However, the efficiencyand applicability of proteome analysis has been dramatically increased recently. We are on the way to be ableto comprehensively assess disease-related proteome alterations, which may become an essential source ofinformation for knowledge-based drug design. This review will provide an overview of current techniques inproteome analysis, focusing on screening technologies for biomedical research. An outlook at the futurepotential of proteomics supported by modern bioinformatics will highlight why proteomics is worth the effort.
Keywords: 2d-page, autoradiography, fluorography, mass spectrometry, mudpit, quantitative, proteomics
Combinatorial Chemistry & High Throughput Screening
Title: (Review Article) Screening for Disease-Markers and Investigating Drug Effects by Proteome Profiling: Can it Meet Expectations?
Volume: 7 Issue: 1
Author(s): Christopher Gerner
Affiliation:
Keywords: 2d-page, autoradiography, fluorography, mass spectrometry, mudpit, quantitative, proteomics
Abstract: Drugs exert their functions mainly by affecting proteins. Therefore, it seems straightforward to focus on proteins in order to investigate drug effects. Unfortunately, proteins are of very high complexity, rendering it much more difficult to screen for protein alterations as compared to gene regulation. However, the efficiencyand applicability of proteome analysis has been dramatically increased recently. We are on the way to be ableto comprehensively assess disease-related proteome alterations, which may become an essential source ofinformation for knowledge-based drug design. This review will provide an overview of current techniques inproteome analysis, focusing on screening technologies for biomedical research. An outlook at the futurepotential of proteomics supported by modern bioinformatics will highlight why proteomics is worth the effort.
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Cite this article as:
Gerner Christopher, (Review Article) Screening for Disease-Markers and Investigating Drug Effects by Proteome Profiling: Can it Meet Expectations?, Combinatorial Chemistry & High Throughput Screening 2004; 7 (1) . https://dx.doi.org/10.2174/138620704772884779
DOI https://dx.doi.org/10.2174/138620704772884779 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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