ISSN (Print): 0929-8665
ISSN (Online): 1875-5305
Volume 25, 12 Issues, 2018
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ISSN (Print): 0929-8665
ISSN (Online): 1875-5305
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Special Issue Submission
"Protein and Peptide Letters provides an excellent venue for communication of succinct reports of interesting research findings."
Jeffrey J. Gorman
Institute of Molecular Bioscience, Australia
Applications of Environment Stress Related Protein in Grass Improvement
Guest Editor(s): Meiliang Zhou, Yanmin Wu
Tentative Publication Date: May, 2016
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Advances in Therapeutic Glycopetides
Guest Editor(s): Wenbing Zeng, Yue-Lei Chen
It was a great experience working with Bentham Science Publishers. The reviews were fair, prompt and the suggestions given made us analyze our work more deeply and unearth important issues and their solutions.
The proof-reading process of Bentham Science was also prompt and author-friendly. They took utmost care to ensure that all of our concerns were addressed in the final published form of the paper. The discounts offered to authors were also most appreciated.
The fast communication and periodical updates made us submit another research paper to Bentham Science Publishers in their journal, Current Bioinformatics, which is currently under review
Thank you Bentham Science Publishers!
Assistant Professor. Shomona GJ (Department of CSE, SSN College of Engineering, Chenniai, India)
2 Abstract Ahead of Print are available electronically
8 Articles Ahead of Print are available electronically
In developed countries, subfertility has become an increasing problem. Infertility is the inability to conceive after 12 months
of regular, unprotected intercourse. It is a worldwide problem, affecting 15% of couples that have unprotected intercourse. In
general, 50% of infertility cases are due to a solely female factor, pure male factor accounts for 20-30% of the problem, and the
remaining 20-30% is due to a combination of both male and female factors.
Again, one of the common complications of pregnancy is spontaneous pregnancy loss which occurs in an estimated 5-15%
of pregnancies. Although pregnancy loss has been associated to various hematologic, anatomic, hormonal, immune, and genetic
defects, in 30% of the cases, screening tests performed in cases of Repeated Pregnancy Loss (RPL) give negative results.
The last 10 to 15 years have witnessed rapid advances in approaches for the analyses of DNA sequence and structure. The
amount of information currently available about the genomes in human and animal reproduction has increased dramatically in
the past few years and the rate of its accumulation will continue to increase.
Also, proteomics has been widely used over recent years in almost all relevant biological samples (tissues, fluids, cells) to
depict both physiological and pathological states, and has yielded important results, including the significance of posttranslational
modifications in sperm and the intense immunological-inflammatory processes that take place during ovulation
and implantation. Proteomics represents a state-of-the-art, technology-driven science, which, in a high-throughput mode,
studies proteins and their post-translational modifications and interactions. This approach provides the opportunity to elucidate
complex biological processes and conditions, including fertilization, embryo implantation and differentiation and pregnancy.
Proteomics is providing useful insights into physiology of human reproduction and it is leading to the identification of
numerous proteins in biological tissues and fluids related to human reproduction that may be potential biomarkers and/or
treatment targets. In the area of reproduction, this approach seems to be the most promising and powerful platform that has
been recently applied in order to widely study the physiology and pathophysiology of reproduction and to identify novel
markers of diseases.
In the diagnostic of male infertility, semen analysis represents the cornerstone for the assessment of the male partner in subfertile
couples. Many studies, however, criticized the thresholds used to define male factor infertility using sperm concentration,
motility and morphology, the three classical sperm parameters measured by all laboratories. Additional markers of male fertility
have been proposed including the evaluation of anti-sperm antibodies, biochemical tests, kinematic parameters, sperm DNA
integrity and oxidative stress markers. However, due to the lack of a standardized and universally accepted assays and the
expensive or time-consuming techniques, these parameters did not reveal a role in the clinical workout of male infertility.
Therefore, several sources of clinical biomarkers have been proposed for female reproductive tract disease and cervical
mucus represents the most promising source of biomarkers reflecting the health of the male tract.
This special issue of Protein & Peptide Letters, entitled “Protein and peptide markers in reproduction” intends to showcase
new results and express the opinions of a selection of specialists who have expanded the field with their recent discoveries.
In the opening paper of this issue, Dr. Bibancos and co-authors discuss the potential use of proteomic platforms in the
workflow of couple infertility in clinical practice. Beyond the identification of the oocytes and embryos with the best
developmental potentials in assisted reproductive techniques or prediction of a pregnancy’s outcome, it may add significant
information for the diagnosis of both male and female infertility .
The most abundant sperm nuclear proteins are protamins. Dr. Oliva, in addition to briefly reviewing the studies available so
far about protamine alterations and male infertility, provided a very comprehensive protocol for the successful implementation
of protamine extraction and analysis into the laboratory routine, including protocol variations for specific procedure
The post-genomic approaches in the study of male sperm function, consisting of different methodologies for concurrently
testicular transcriptome studies, protein compositional analysis and metabolomics findings, have been reviewed by Dr. Dipresa
Dr. Luca summarized some of the recent findings regarding the immunomodulatory role of Sertoli cells, and especially the
key Sertoli cell regulatory proteins that are associated with the well-defined immune privileged status of the testis .
Dr. De Toni analyzed the most recent cues about the molecular bases of the known process of sperm thermotaxis, and the
possible pathophysiological and therapeutic repercussions deriving from the characterization of sperm proteins acting as
Furthermore, the expression in sperm surface of specific nicotine receptors might represent a marker of sperm smokingrelated
damage. Dr. La Vignera discussed in his manuscript the mechanism by which nicotine alters spermatozoa and the
expression pattern of nicotinic receptors subunits in human spermatozoa .
In addition Dr. Di Nicuolo reviewed the role of inflammosome in female reproduction and namely in RPL .
Dr. Fernandez-Hermida in her review article collected relevant knowledge about the physicochemical properties and
functions of the cervical mucus, including its important role as a clinical marker of female fertility, and draws attention to
cervical mucus as the best source of potential protein biomarkers to assess the health of female genital tract .
Proteomic platforms have been applied to identify novel markers of disease in seminal plasma. Dr. Grande reported a
research article aimed to identify, for the first time, novel seminal biomarkers for the male tract infection by Enterococcus
faecalis, using proteomic profiling, in order to understand the effect of E. faecalis on the physiopathology of male reproduction
Among the proposed markers of Male Accessory Gland Inflammation (MAGI), soluble urokinase-type plasminogen
activator receptor (suPAR) has been recently proposed as a reliable and sensitive marker. In the study by Milardi et al., the role
of suPAR as a protein marker of MAGI was confirmed in hypogonadism, supporting the hypothesis that hypogonadism induces
a state of inflammation in male accessory glands which is involved in male infertility .
In summary, experts from the field of male and female reproduction have presented new results and reviewed the current
advances in their specific area in this special thematic issue of Protein & Peptide Letters. As the guest editors, we wish that this
diverse collection of articles will gain broad readership.
The protein and peptide analysis provides a good starting point to discover new reproduction-related proteins; however,
further functional analyses should be conducted to gain a specific role for fertility traits in human reproduction metabolism. The
comprehensive proteomic profiling of human reproduction and its pathology constitutes a major challenge for the international
We would like to express our sincere gratitude to all authors and referees for their contribution to this issue. We would also
like to extend our appreciation to the Editor-in-Chief, Professor Ben M. Dunn and the editorial staff of Protein & Peptide
Letters, especially Ms Amna Sajid, for their excellent support and for providing us with the opportunity to pursue this hot topic
Global warming, diminishing fossil fuel resources and growing energy requirements have kindled the
research on alternative fuels. Moreover, cleaner production and sustainable consumption of industrial
products have become forefront research areas in recent years. The special issue “Recent trends in
biofuels and bio-industry” focusses on the emerging trends in this area. Original research articles
presenting the cornerstone technologies to address the bottleneck issues in biofuel and bio-industrial
processes, and critical review articles analyzing the challenges and discussing the future opportunities are
welcomed. The submissions focusing on the characterization/engineering of novel proteins/enzymes of
industrial/biofuel importance, identification/engineering/synthesis of metabolic pathways for biofuels and
industrial chemicals, would be highly appreciated.
In the last decade, materials synthesis and processing under conditions with low energy consumptions have been gathering attractive interests for building sustainable societies. Because biominerals are precisely-designed composite materials made from the combinations of inorganic minerals such as calcium carbonate, silica, hydroxyapatite and organic template molecules such as proteins and peptides under ambient conditions, biomimetic production of organic-inorganic hybrid nanomaterials would be one of the approaches to provide a variety of morphologies and arrangements of inorganic components for fabrications and applications. So far, many scientists/chemists have devoted their great efforts to control morphologies of inorganic precipitates using organic compounds such as polymers, surfactants, and so on. Proteins and peptides are promising organic template molecules for use in the biomimetic process because they confer several advantages: 1) proteins and peptides can offer milder conditions for the production, 2) proteins and peptides can impose on the size, shape, and crystal structure of the inorganic products, 3) proteins and peptides can offer the potential to produce materials with highly specific or multiple functions. Therefore, the rapid progress in the development of synthesis and processing of organic-inorganic hybrid materials is evident and the compilation of the subtopics listed below would appear to be timely. This theme issue intends to offer for understanding new knowledge on protein- and/or peptide-associated materials and propose unprecedented and fundamental concepts as well as some directions to their practical applications. The theme issue included in the following potential subtopics, but are not limited to:
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