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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Synthetic Studies on V-ATPase Inhibiting Macrolide Antibiotics

Author(s): Kazunobu Toshima

Volume 8, Issue 2, 2004

Page: [185 - 210] Pages: 26

DOI: 10.2174/1385272043486043

Price: $65

Abstract

Synthetic studies on the specific inhibitors of vacuolar-type H+-ATPase, bafilomycins, hygrolidines, and concanamycins, are described. Bafilomycins and hygrolidins are 16-membered and concanamycins are 18- membered plecomacrolides, which have very complex molecular structures.

Keywords: V-ATPase, hygrolidines, plecomacrolides

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