Abstract
Extracellular signal-regulated kinases 1 and 2 (ERKs) are central regulators of many physiological and pathological processes. Their activity is regulated by phosphorylation on both tyrosine and threonine residues within their activation loops by MAPK / ERK kinases 1 and 2 (MEKs). Removal of phosphate from either the tyrosine, the threonine, or from both residues together can inactivate ERKs. Indeed members of the three groups of protein phosphatases, protein Ser / Thr phosphatase, protein Tyr phosphatase, and dual specificity phosphatases have been implicated in the inactivation of ERKs. In this review, we describe the various mechanisms involved in the inactivation of ERKs during different stages of mitogenic stimulation of quiescent cells.
Keywords: erk, mapk, mkp, protein tyr phosphatase, protein ser thr phosphatase
Current Genomics
Title: The Molecular Mechanism of MAPK / ERK Inactivation
Volume: 5 Issue: 4
Author(s): Zhong Yao and Rony Seger
Affiliation:
Keywords: erk, mapk, mkp, protein tyr phosphatase, protein ser thr phosphatase
Abstract: Extracellular signal-regulated kinases 1 and 2 (ERKs) are central regulators of many physiological and pathological processes. Their activity is regulated by phosphorylation on both tyrosine and threonine residues within their activation loops by MAPK / ERK kinases 1 and 2 (MEKs). Removal of phosphate from either the tyrosine, the threonine, or from both residues together can inactivate ERKs. Indeed members of the three groups of protein phosphatases, protein Ser / Thr phosphatase, protein Tyr phosphatase, and dual specificity phosphatases have been implicated in the inactivation of ERKs. In this review, we describe the various mechanisms involved in the inactivation of ERKs during different stages of mitogenic stimulation of quiescent cells.
Export Options
About this article
Cite this article as:
Yao Zhong and Seger Rony, The Molecular Mechanism of MAPK / ERK Inactivation, Current Genomics 2004; 5 (4) . https://dx.doi.org/10.2174/1389202043349309
DOI https://dx.doi.org/10.2174/1389202043349309 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
PEDF & Stem Cells: Niche vs. Nurture
Current Drug Delivery New Treatment Concepts In Diffuse Large B-Cell Lymphomas (DLBL): Chemotherapy and Biological Therapy
Reviews on Recent Clinical Trials What Does Systems Biology Mean for Drug Development?
Current Medicinal Chemistry Recent Insights into Notch Signaling in Embryonal Rhabdomyosarcoma
Current Drug Targets Endogenous Angiogenesis Inhibitors as Therapeutic Agents: Historical Perspective and Future Direction
Recent Patents on Anti-Cancer Drug Discovery Neoadjuvant Chemotherapy Before Radical Cystectomy: Why We Must Adhere?
Current Drug Targets To Enhance or to Inhibit Integrin Function in Angiogenesis, that is the Question
Current Angiogenesis (Discontinued) Interventional Radiology Procedures: Current Issues in Patient Doses and Image Quality Optimization
Current Medical Imaging Emerging Treatment Strategies and Potential Therapeutic Targets in Primary Sjogrens Syndrome
Inflammation & Allergy - Drug Targets (Discontinued) Structure-Based Virtual Screening for Drug Discovery: Principles, Applications and Recent Advances
Current Topics in Medicinal Chemistry Variation of Pharmacokinetic Profiles of Some Antidiabetic Drugs from Nanostructured Formulations Administered Through Pulmonary Route
Current Drug Metabolism Endothelial Dysfunction in Diabetes: From Mechanisms to Therapeutic Targets
Current Medicinal Chemistry Anti-Inflammatory Properties of Drugs from saffron crocus
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Pharmacotherapies to Manage Bone Loss-Associated Diseases: A Quest for the Perfect Benefit-to-Risk Ratio
Current Medicinal Chemistry The Preclinical Bases of the Rational Combination of Paclitaxel and Antiangiogenic Drugs
Clinical Cancer Drugs Botulinum Toxin a in Prostate Disease: A Venom from Bench to Bed-Side
Current Drug Delivery Circadian Clock Gene of Grass Carp (Ctenopharyngodon idellus): Genomic Structure and Tissue Expression Pattern of Period1 Gene
Current Bioinformatics Small Molecules ATP-Competitive Inhibitors of FLT3: A Chemical Overview
Current Medicinal Chemistry Electrochemical Behaviors and Determinations of Some 2,5-Disubstituted Benzoxazole Compounds at the Hanging Mercury Drop Electrode
Current Pharmaceutical Analysis Absorption, Disposition and Pharmacokinetics of Solid Lipid Nanoparticles
Current Drug Metabolism