Medicinal Chemistry

Editor-in-Chief:

Dimitra Hadjipavlou-Litina
Aristotle University of Thessaloniki
Thessaloniki
Greece

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Ahead of Print Article(s)

QSAR and Pharmacophore Mapping Studies on Benzothiazinimines to Relate their Structural Features with anti-HIV Activity

Volume:14
Gopiraja Geethaavacini, Go Poh Poh, Lim Yi Yan, Rajindran Deepashini , Sivadasan Shalini, Rajak Harish, Krishnan Sureshkumar and Veerasamy Ravichandran*

Crystal Structure of Mistletoe Lectin I (ML-I) from Viscum album in Complex with 4-N-Furfurylcytosine at 2.85 Å Resolution

Volume:14
Malik Shoaib Ahmad*, Saima Rasheed, Sven Falke, Binish Khaliq, Markus Perbandt, M. Iqbal Choudhary, Wojciech T. Markiewicz, Jan Barciszewski and Christian Betzel*

Inhibition of Mutated Isocitrate Dehydrogenase 1 in Cancer

Volume:14
Fangrui Wu, Gang Cheng, Yuan Yao, Mari Kogiso, Hong Jiang, Xiao-Nan Li and Yongcheng Song*

Pyrazole and imidazo[1,2-b]pyrazole Derivatives as New Potential Antituberculosis Agents

Volume:14
Elda Meta, Chiara Brullo*, Michele Tonelli, Scott G. Franzblau, Yuehong Wang, Rui Ma, Wan Baojie , Beatrice Silvia Orena, Maria Rosalia Pasca and Olga Bruno

Molecular Interaction and Computational Analytical Studies of Pinocembrin for its Antiangiogenic Potential Targeting VEGFR-2: A Persuader of Metastasis

Volume:14
Neha Sharma, Mala Sharma, Eram Shakeel, Qazi M Sajid Jamal, Mohammad A. Kamal, Usman Sayeed, Mohammad K.A. Khan, Mohammad H. Siddiqui, Jamal M. Arif and Salman Akhtar*

Design of Bactericidal Peptides Against Escherichia coli O157:H7, Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus

Volume:14
Jenniffer Cruz, Paola Rondon , Rodrigo Torres, Mauricio Urquiza, Fanny Guzman, Claudio Alvarez, Maria Angeles Abengozar, Daniel A. Sierra, Luis Rivas, Roberto Fernandez-Lafuente and Claudia Ortiz*

Synthetic Diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylates Induce Apoptosis

Volume:14
Seunghyun Ahn, Youngshim Lee, Jihyun Park, Junho Lee, Soon Young-Shin, Young Han Lee, Dongsoo Koh* and Yoongho Lim*

Synthesis and Antibacterial Activity Against MRSA of Pleuromutilin Derivatives Possessing a Mercaptoethylamine Linker

Volume:14
Zhao-Sheng Zhang, Yun-Zhen Huang, Jian Luo, Bing-Feng Wang, Zhen Jin, Ya-Hong Liu and You-Zhi Tang*

Evaluation of Trypanocidal and Antioxidant Activities of a Selected Series of 3-amidocoumarins

Volume:14
Mauricio Moncada-Basualto, Michel Lapier, Juan Diego Maya, Betty Matsuhiro, Claudio Olea-Azar*, Giovanna L. Delogu, Eugenio Uriarte, Lourdes Santana and Maria Joao Matose

Diclofenac 1,3,4-Oxadiazole Derivatives; Biology-Oriented Drug Synthesis (BIODS) in Search of Better Non-Steroidal, Non-Acid Antiinflammatory Agents

Volume:14
Shazia Shah, Arshia, Nida Siraj Kazmi, Almas Jabeen, Aisha Faheem, Nida Dastagir, Tariq Ahmed, Khalid Mohammed Khan*, Shakil Ahmed, Abeer Raza and Shahnaz Perveen

Benzoin Schiff Bases: Design, Synthesis, and Biological Evaluation as Potential Antitumor Agents

Volume:14
Dima A. Sabbah*, Fatima Al-Tarawneh, Wamidh H. Talib, Kamal Sweidan, Sanaa K. Bardaweel, Eveen Al-Shalabi, Haizhen A. Zhong, Ghassan Abu Sheikha, Reema Abu Khalaf and Mohammad S. Mubarak

Construction of an M1GS Ribozyme for Targeted and Rapid mRNA Cleavage; Application on the Ets-2 Oncogene

Volume:14
Chrisavgi Toumpeki, Dimitrios Anastasakis, Ioannis Panagoulias, Vassiliki Stamatopoulou, Tassos Georgakopoulos, Sofia Kallia-Raftopoulos, Athanasia Mouzaki* and Denis Drainas*

Synthesis of a Tyr-Tyr Dipeptide Library and Evaluation Against Tumor Cells

Volume:14
Stanley NS Vasconcelos, Juliana M. Sciani, Nicole Mambeli Lisboa and Helio A Stefani*

Anti-diabetic Phenolic Compounds of Black Carrot (Daucus carota Subspecies sativus var. atrorubens Alef.) Inhibit Enzymes of Glucose Metabolism: An in silico and in vitro Validation

Volume:14
Suhas Gorakh Karkute, Tanmay Kumar Koley*, Bijen Kumar Yengkhom, Ajay Tripathi, Shivani Srivastava, Arti Maurya and Bijendra Singh

Synthesis and Biological Evaluation of 12N-substituted Tricyclic Matrinic Derivatives as a Novel Family of Anti-Influenza Agents

Volume:14
Sheng Tang, Yu-Huan Li , Xin–Yue Cheng, Jin–Qiu Yin , Ying–Hong Li , Dan–Qing Song , Yan–Xiang Wang * and Zhan–Dong Liu

Emerging Roles of Purinergic Signaling in Diabetes

Volume:14
Carmen Fotino, Diego Dal Ben and Elena Adinolfi*

Activity of Diosgenyl 2-amino-2-deoxy-β-D-glucopyranoside, its Hydrochloride, and N,N-dialkyl Derivatives Against Non-albicans Candida Isolates

Volume:14
Malgorzata Anna Dawgul*, Daria Grzywacz, Beata Liberek, Wojciech Kamysz and Henryk Myszka

Design and Synthesis of 3,4-diarylpyrrole Analogues as Potent Topoisomerase Inhibitors

Volume:14
Qiang Zhao, Wang Chen*, Xu He, Zili Feng and Qi Liang

Synthesis of Oleanolic Acid Analogues and Their Cytotoxic Effects on 3T3 Cell Line

Volume:14
Salih Tuncay , Halil Senol, Eray Metin Guler , Nuket Ocal , Hasan Secen , Abdurrahim Kocyigit and Gulacti Topcu *

Identification of New Chromenone Derivatives as Cholinesterase Inhibitors and Molecular Docking Studies

Volume:14
Jamshed Iqbal *, Muhammad Shakeel Ahmad Abbasi, Sumera Zaib , Saifullah Afridi, Norbert Furtmann, Jurgen Bajorath and Peter Langer

Synthesis and Structure-Activity Relationship; Exploration of Some Potent Anti-Cancer Phenyl Amidrazone Derivatives

Volume:14
Almeqdad Y. Habashneh, Mustafa M. El-Abadelah, Sanaa K Bardaweel and Mutasem O. Taha*

Xanthine Oxidase Inhibitory and Molecular Docking Studies on Pyrimidones

Volume:13
Humaira Zafar, Sarosh Iqbal, Sumaira Javaid, Khalid M. Khan* and Muhammad I. Choudhary*

Synthesis and Characterization of Thiocarbohydrazones and their Inhibitory Potential Against Ignored Disease Leishmaniasis

Volume:14
Nida Ghouri*, Khalid Mohammed Khan, Arshia, M Iqbal Choudhary and Shahnaz Perveen

New Bis-Pyrazolones as Potential Leads for ROS Inhibition; Environment Friendly Green Synthesis, Structural Characterization, and In Vitro Studies

Volume:14
Sahar Yousuf*, Khalid Mohammed Khan, Uzma Salar, Almas Jabeen, Shakil Ahmed, Munira Taj Muhammad, Aisha Faheem and Shahnaz Perveen

Facile Synthesis, Crystal Structure, DFT Calculation and Biological Activities of 4-(2-fluorophenyl)-3-(3-methoxybenzyl)-1H-1,2,4-triazol-5(4H)-one (5)

Volume:14
Muhammad Saleem, Muhammad Rafiq, Yeon Ki Jeong, Dae Won Cho, Chong-Hyeak Kim, Sung-Yum Seo, Chang-Shik Choi, Seong-Karp Hong and Ki-Hwan Lee*

Anti-Trypanosoma cruzi Activity in vitro of Phases and Isolated Compounds from Excoecaria lucida Leaves

Volume:14
Cristiane Franca da Silva*, Ania Ochoa Pacheco, Rayane Nogueira Alves, Josean Fechine Tavares, Marcelo Sobral da Silva and Julio Cesar Escalona Arranz

Prodrugs For Nitroreductase Based Cancer Therapy- 1 Metabolite Profile, Cell Cytotoxicity and Molecular Modeling Interactions of Nitro Benzamides with Ssap-NtrB

Volume:13
Tugba Gungor, Gulden Yetis, Ferah Cömert Onder, Esra Tokay, Tugba Taşkın Tok, Ayhan Celik, Mehmet Ay* and Feray Kockar

Inhibition of Adipogenesis by Thiourea Derivatives

Volume:13
Hina Siddiqui*, Sarah Shafi, Farah Mukhtar, Asma Ejaz, Atta-ur-Rahman and M. Iqbal Choudhary*

Antibacterial Assessment of Heteroaryl, Vinyl, Benzyl, and Alkyl Tetrazole Compounds

Volume:13
Joshua Dudley, Liana Feinn, Heather DeFrancesco, Erica Lindsay, Adiel Coca* and Elizabeth Lewis Roberts

Anthranilic Acid Derivatives: Novel Inhibitors of Protein Glycation and the Associated Oxidative Stress in the Hepatocytes

Volume:13
Humera Jahan*, Muhammad Iqbal Choudhary, Amber Atta, Khalid Mohammad Khan and Atta-ur- Rahman