Medicinal Chemistry

Editor-in-Chief:

Dimitra Hadjipavlou-Litina
Aristotle University of Thessaloniki
Thessaloniki
Greece

Back

Become EABM
Become Reviewer

Articles Ahead of Print

The Substantial Improvement of Amphotericin B Selective Toxicity Upon Modification of Mycosamine with Bulky Substituents

Volume:15
Edward Borowski, Natalia Salewska, Joanna Boros-Majewska, Marcin Serocki, Izabela Chabowska, Maria J. Milewska, Dominik Ziętkowski and Sławomir Milewski*

New Quinazoline-Sulfonylurea Conjugates: Design, Synthesis and Hypoglycemic Activity

Volume:15
Sahar M. Abou-Seri, AlShaimaa M. Taha, Mona A. Mohamed* and Nour M. Abdelkader

Synthesis and Biological Studies of New Multifunctional Curcumin Platforms for Anticancer Drug Delivery

Volume:15
Andrii Bazylevich , Helena Tuchinsky, Eti Zigman-Hoffman, Ran Weissman , Ofer Shpilberg , Oshrat Hershkovitz-Rokah, Leonid Patsenker and Gary Gellerman*

Design, Synthesis and In Vitro Evaluation of Novel Anti-HIV 3-Pyrazol-3- yl-Pyridin-2-One Analogs

Volume:15
Sanjay Kumar, Shiv Gupta, Shraddha Gaikwad, Leila Fotooh Abadi, Late Kamlesh Kumar Bhutani, Smita Kulkarni* and Inder Pal Singh*

Efficacy of Novel Schiff base Derivatives as Antifungal Compounds in Combination with Approved Drugs Against Candida Albicans

Volume:15
Manzoor Ahmad Malik, Shabir Ahmad Lone, Parveez Gull, Ovas Ahmad Dar, Mohmmad Younus Wani, Aijaz Ahmad* and Athar Adil Hashmi*

The Inhibition of Polysialyltranseferase ST8SiaIV Through Heparin Binding to Polysialyltransferase Domain (PSTD)

Volume:15
Li-Xin Peng, Xue-Hui Liu, Bo Lu, Si-Ming Liao, Feng Zhou, Ji-Min Huang, Dong Chen, Frederic A. Troy II, Guo-Ping Zhou* and Ri-Bo Huang*

The Multiple Applications and Possible Mechanisms of the Hyperbaric Oxygenation Therapy

Volume:15
Wan Chen, Xingmei Liang , Zhihuan Nong, Yaoxuan Li, Xiaorong Pan, Chunxia Chen * and Luying Huang*

Inhibition of α-amylase Activity by Zn2+: Insights from Spectroscopy and Molecular Dynamics Simulations

Volume:15
Si-Ming Liao, Nai-Kun Shen, Ge Liang, Bo Lu, Zhi-Long Lu, Li-Xin Peng, Feng Zhou, Li-Qin Du, Yu-Tuo Wei, Guo-Ping Zhou* and Ri-Bo Huang*

Evaluation of Cytotoxic Potentials of Some Isoindole-1, 3-Dione Derivatives on HeLa, C6 and A549 Cancer Cell Lines

Volume:15
Ayse Tan, Ayse Sahin Yaglioglu, Nurhan Horasan Kishali*, Ertan Sahin and Yunus Kara*

Design and Synthesis of Novel Sulfonamide-Derived Triazoles and Bioactivity Exploration

Volume:14
Shi-Chao He, Hui-Zhen Zhang*, Hai-Juan Zhang, Qing Sun and Cheng-He Zhou

Novel Conjugated Unsaturated Ketones with Submicromolar Potencies Towards some Leukemic and Colon Cancer Cells

Volume:14
Swagatika Das, H. Inci Gul, Umashankar Das*, Jan Balzarini, Stephen G. Dimmock and Jonathan R. Dimmock *

Design, Synthesis and Anxiolytic Activity Evaluation of N-Acyltryptophanyl- Containing Dipeptides, Potential TSPO Ligands

Volume:15
T. A. Gudasheva, O. A. Deeva, G. V. Mokrov, A. S. Dyabina, M. A. Yarkova and S. B. Seredenin

Phenolic Imidazole Derivatives with Dual Antioxidant/Antifungal Activity: Synthesis and Structure-Activity Relationship

Volume:14
Ana P. Bettencourt, Marian Castro, Joao P. Silva, Francisco Fernandes, Olga P. Coutinho, Maria J. Sousa, M. Fernanda Proenca* and Filipe M. Areias*

Pyrrolopyrazoles: Synthesis, Evaluation and Pharmacological Screening as Antidepressant Agents

Volume:14
Samar Said Fatahala*, Shahira Nofal, Eman Mahmoud and Rania Helmy Abd El-hameed

Synthesis and Evaluation of Antifungal and Antitrypanosomastid Activities of Symmetrical 1,4-Disubstituted-1,2,3-Bistriazoles Obtained by CuAAC Conditions

Volume:14
Mauricio M. Victor*, Ravir R. Farias, Danielle L. da Silva, Paulo Henrique Fonseca do Carmo, Maria A. de Resende-Stoianoff, Claudio Viegas, Patricia F. Espurie and Marcos J. Marquese

Synthesis, Anti-Varicella-Zoster Virus and Anti-Cytomegalovirus Activity of 4,5-Disubstituted 1,2,3-(1H)-Triazoles

Volume:14
Wei-yuan Yuan, Xue Chen, Ning-ning Liu, Yi-ning Wen, Bei Yang, Graciela Andrei, Robert Snoeck, Yu-hong Xiang, Yong-wei Wu, Zhen Jiang, Dominique Schols, Zhuo-yong Zhang and Qin-pei Wu*

Small Molecular Leads Differentially Active Against HER2 Positive and Triple Negative Breast Cancer Cell Lines

Volume:14
Adnan Badran, Atia-tul-Wahab, Sharmeen Fayyaz, Elias Baydoun and M. Iqbal Choudhary*

Design, Synthesis and Anticancer Evaluation of Novel Series of Indibulin Analogues

Volume:14
Ebrahim Saeedian Moghadam, Farhad Saravani, Seyednasser Ostad, Shohreh Tavajohi, Morteza Pirali Hamedani and Mohsen Amini*

Synthesis and Biological Evaluation of Acridine/Acridone Analogs as Potential Anticancer Agents

Volume:14
Monika Gensicka-Kowalewska, Mirosława Cichorek, Anna Ronowska, Milena Deptuła, Ilona Klejbor and Krystyna Dzierzbicka*

Evaluation of Antiplasmodial Potential of C-2 and C-8 Modified Quinolines: in vitro and in silico Study

Volume:14
Rakesh Kumar, Ritika Sharma, Inder Kumar, Pooja Upadhyay, Ankit Kumar Dhiman, Rohit Kumar, Rakesh Kumar, Rituraj Purohit*, Dinkar Sahal* and Upendra Sharma*

Synthesis and Biological Evaluation of Scutellarein Alkyl Derivatives as Preventing Neurodegenerative Agents with Improved Lipid Soluble Properties

Volume:14
He-Min Li, Ting Gu, Wen-Yu Wu, Shao-Peng Yu, Tian-Yuan Fan, Yue Zhong and Nian-Guang Li*

Synthesis and Biological Evaluation of 3-cyano-4H-chromene Derivatives Bearing Carbamate Functionality

Volume:14
Fatma Boukattaya, Amal Daoud, Fabien Boeda, Morwenna S. M. Pearson-Long, Neji Gharsallah, Adel Kadri, Philippe Bertus* and Houcine Ammar

Identification, Prediction and Data Analysis of Noncoding RNAs: A Review

Volume:14
Abbasali Emamjomeh*, Javad Zahiri, Mehrdad Asadian, Mehrdad Behmanesh, Barat Ali Fakheri and Ghasem Mahdevar

Design, Synthesis, Antimicrobial and Anti-biofilm Evaluation, and Molecular Docking of Newly Substituted Fluoroquinazolinones

Volume:14
Mohamed F. Zayed, Sabrin R.M. Ibrahim*, EL-Sayed E. Habib, Memy H. Hassan, Sahar Ahmed and Heba S. Rateb

Carbonic Anhydrase Inhibitory Potential of 1,2,4-triazole-3-thione Derivatives of Flurbiprofen, Ibuprofen and 4-tert-butylbenzoic Hydrazide: Design, Synthesis, Characterization, Biochemical Evaluation, Molecular Docking and Dynamic Simulation Studies

Volume:14
Saghir Abbas, Sumera Zaib, Shafiq Ur Rahman, Saqib Ali*, Shahid Hameed, Muhammad Nawaz Tahir, Khurram Shahzad Munawar, Farzana Shaheen, Syed Mustansar Abbas and Jamshed Iqbal*

Synthesis and Biological Evaluation of Polyfluoroalkylated Antipyrines and their Isomeric O-Methylpyrazoles

Volume:14
Natalya Agafonova, Evgeny Shchegolkov*, Yanina Burgart, Victor Saloutin, Alexandra Trefilova, Galina Triandafilova, Sergey Solodnikov, Vera Maslova, Sophia Borisevich, Olga Krasnykh and Sergey Khursan

Antiprotozoal Activities of Tetrazole-quinolines with Aminopiperidine Linker

Volume:14
Patrick Hochegger, Johanna Faist, Werner Seebacher, Robert Saf, Pascal Mäser, Marcel Kaiser and Robert Weis*

Rational Design of Colchicine Derivatives as anti-HIV Agents via QSAR and Molecular Docking

Volume:14
Apilak Worachartcheewan*, Napat Songtawee, Suphakit Siriwong, Supaluk Prachayasittikul*, Chanin Nantasenamat and Virapong Prachayasittikul

Synthesis of New Thiosemicarbazones and Semicarbazones Containing the 1,2,3-1H-triazole-isatin Scaffold: Trypanocidal, Cytotoxicity, Electrochemical Assays, and Molecular Docking

Volume:14
Bianca N. M. Silva, Policarpo A. Sales , Alvaro J. Romanha, Silvane M. F. Murta, Camilo H. S. Lima, Magaly G. Albuquerque, Eliane D'Elia, Jose G. de Aquino, Vitor F. Ferreira, Fernando C. Silva, Angelo C. Pinto and Barbara V. Silva*

Ligand-Based Drug Design: Synthesis and Biological Evaluation of Substituted Benzoin Derivatives as Potential Antitumor Agents

Volume:14
Dima A. Sabbah*, Ameerah Hasan Ibrahim, Wamidh H. Talib, Khalid M. Alqaisi, Kamal Sweidan, Sanaa K. Bardaweel, Ghassan Abu Sheikha, Haizhen A. Zhong, Eveen Al-Shalabi, Reema Abu Khalaf and Mohammad S. Mubarak

Synthesis, 2D-QSAR Studies and Biological Evaluation of Quinazoline Derivatives as Potent Anti-Trypanosoma cruzi Agents

Volume:14
Mariela Bollini, Ana María Bruno*, María Eugenia Niño, Juan José Casal, Leandro Daniel Sasiambarrena, Damián Ariel González Valdez, Leandro Battini, Vanesa Rocío Puente and María Elisa Lombardo

New N,C-Diaryl-1,2,4-triazol-3-ones: Synthesis and Evaluation as Anticancer Agents

Volume:14
Dolores Santa Maria*, Rosa M. Claramunt, Jose Elguero, Miguel Carda, Eva Falomir and Celia Martin-Beltran

Anticancer Activity and Topoisomerase II Inhibition of Naphthalimides with ω-Hydroxylalkylamine Side-Chains of Different Lengths

Volume:14
Mateusz D. Tomczyk, Anna Byczek Wyrostek, Klaudia Strama, Martyna Wawszków, Przemysław Kasprzycki and Krzysztof Z. Walczak*

Antiproliferative Activity and Characterization of Metabolites of Aspergillus nidulans: An Endophytic Fungus from Nyctanthes arbor-tristis Linn. Against Three Human Cancer Cell Lines

Volume:14
Talea Sana, Bina S. Siddiqui*, Saleem Shahzad, Ahsana D. Farooq, Faheema Siddiqui, Samia Sattar and Sabira Begum

Design, Synthesis, and Biological Evaluation of Novel Thiazolyl Substituted Bis-pyrazole Oxime Derivatives with Potent Antitumor Activities by Selectively Inducing Apoptosis and ROS in Cancer Cells

Volume:14
Biao Xiong, Shi Chen, Peng Zhu, Meili Huang, Weijie Gao, Rui Zhu, Jianqiang Qian, Yanfu Peng, Yanan Zhang, Hong Dai and Yong Ling*

ZnO Nanoparticles Catalyst in the Synthesis of Bioactive Fused Pyrimidines as Anti-breast Cancer Agents Targeting VEGFR-2

Volume:14
Dina H. Dawood, Eman M. H. Abbas, Thoraya A. Farghaly*, Mamdouh M. Ali and Mohammed F. Ibrahim

Synthesis & Anticancer Evaluation of New Substituted 2-(3,4- Dimethoxyphenyl)benzazoles

Volume:14
Cigdem Karaaslan , Yalcin Duydu, Aylin Ustundag , Can Ozgur Yalcin, Banu Kaskatepe and Hakan Goker*

Synthesis and Structural Elucidation of Novel Benzothiazole Derivatives as Anti-tubercular Agents: In-silico Screening for Possible Target Identification

Volume:14
Katharigatta N. Venugopala*, Sandeep Chandrashekharappa, Melendhran Pillay, Subhrajyoti Bhandary, Mahmoud Kandeel, Fawzi M. Mahomoodally , Mohamed A. Morsy, Deepak Chopra , Bandar E. Aldhubiab, Mahesh Attimarad, Osama I. Alwassil , Sree Harsha and Koleka Mlisana