Medicinal Chemistry

Editor-in-Chief:

Dimitra Hadjipavlou-Litina
Aristotle University of Thessaloniki
Thessaloniki
Greece

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Articles Ahead of Print

The Introduction of Hydrazone, Hydrazide, or Azepane Moieties to the Triterpenoid Core Enhances an Activity Against M. tuberculosis

Volume:16
Oxana B. Kazakova*, Natalya I. Medvedeva, Irina E. Smirnova, Tatyana V. Lopatina and Alexander V. Veselovsky

Synthesis and Evaluation of 5-imino-4-thioxoimidazolidin-2-one Derivatives as Antibacterial and Antifungal Agents

Volume:16
Samir Y. Abbas*, Marwa A. M. Sh. El-Sharief, Reem A. K. Al-Harbi, Eman W. El-Gammal and Ahmed M. Sh. El-Sharief

Chemical Properties and Therapeutic Potential of Citral, a Monoterpene Isolated from Lemongrass

Volume:16
Sandeep Sharma, Jeena Gupta*, Shagufta Habib and Debasis Sahu

Benzazole Substituted Iminocoumarins as Potential Antioxidants with Antiproliferative Activity

Volume:16
Nataša Perin, Maja Cindrić, Peter Vervaeke, Sandra Liekens, Tomislav Mašek, Kristina Starčević and Marijana Hranjec*

Synthesized 2-Trifluoromethylquinazolines and Quinazolinones Protect BV2 and N2a Cells against LPS- and H2O2-induced Cytotoxicity

Volume:16
Neeranjini Nallathamby, Chia-Wei Phan, Matej Sova, Luciano Saso and Vikineswary Sabaratnam*

Cytotoxicity, Docking Study of New Fluorinated Fused Pyrimidine Scaffold: Thermal and Microwave Irradiation Synthesis

Volume:16
Alaa M. Abo Alnaja, Thoraya. A. Farghaly*, Heba S. A. El-zahabi and Mohamed R. Shaaban

Study on the Interaction of 1,5-diaryl Pyrrole Derivatives with α- glucosidase; Synthesis, Molecular Docking, and Kinetic Study

Volume:15
Tadesse Bekele Tafesse, Ebrahim Saeedian Moghadam, Mohammed Hussen Bule, Mohammad Ali Faramarzi, Mohammad Abdollahi and Mohsen Amini*

Anti-Cholinesterase Activity of Chalcone Derivatives: Synthesis, In Vitro Assay and Molecular Docking Study

Volume:15
Florentinus D.O. Riswanto, Mira S.A. Rawa, Vikneswaran Murugaiyah, Nurul H. Salin, Enade P. Istyastono, Maywan Hariono and Habibah A. Wahab*

Activity of (-)-Camphene Derivatives Against Mycobacterium tuberculosis in Acidic pH

Volume:15
Hayalla Corrêa de Carvalho, Andressa Lorena Ieque, Tamires Leite Valverde, Vanessa Pietrowski Baldin, Jean Eduardo Meneguello, Paula Aline Zanetti Campanerut-Sá, Fábio Vandresen, Luciana Dias Ghiraldi Lopes, Mariana Regina Passos Souza, Nathally Claudiane de Souza Santos, Vera Lucia Dias Siqueira, Katiany Rizzieri Caleffi-Ferracioli, Regiane Bertin Lima Scodro and Rosilene Fressatti Cardoso*

Synthesis, Characterization, Antioxidant Activity of β-diketonates, and Effects of Coordination to Copper(II) ion on Their Activity: DNA, BSA Interactions and Molecular Docking Study

Volume:15
Nenad Joksimović, Jelena Petronijević, Nenad Janković, Marijana Kosanić, Dušan Milivojević, Milan Vraneš, Aleksandar Tot and Zorica Bugarčić*

Antitumor Effect of Zwitterions of Imidazolium Derived from L- methionine in BALB/c Mice with Lymphoma L5178Y

Volume:15
Karen C. Vargas-Castro, Ana M. Puebla Pérez, Irma I. Rangel-Salas, Jorge I. Delgado-Saucedo, José B. Pelayo-Vázquez, Elvia Becerra-Martínez, A. Aarón Peregrina-Lucano, Raul R. Quiñonez-Lopez, Gabriela J. Soltero-Reynoso and Sara A. Cortes-Llamas*

N-alpha-Aminoacyl Colchicines as Promising Anticancer Agents

Volume:15
Ana Marzo-Mas, Laura Conesa-Milián, Sam Noppen, Sandra Liekens, Eva Falomir*, Juan Murga, Miguel Carda and J. Alberto Marco

Synthesis and Biological Evaluation of Matrine Derivatives as a Novel Family of Potential Anticancer Agents

Volume:15
Jing Wang, Hang Liu, Xiao-Bin Zhuo, Guang-Ming Ye and Qing-Jie Zhao

Design of Arylsulfonylhydrazones as Potential FabH Inhibitors: Synthesis, Antimicrobial Evaluation and Molecular Docking

Volume:16
Thais Batista Fernandes, Natanael Dante Segretti, Felipe Rebello Lourenço, Thalita Marcílio Cândido, André Rolim Baby, Euzébio Guimarães Barbosa and Roberto Parise-Filho*

A Study on Synthesis and Antioxidant Activity Comparison of Novel Stilbenebenzamide Compounds

Volume:16
Aleksandra Kładna, Paweł Berczyński, Oya Bozdağ Dündar, Irena Kruk, Beyza Torun and Hassan Y. Aboul-Enein*

Therapeutic Effects of Ziziphus jujuba Mill. Fruit in Traditional and Modern Medicine: A Review

Volume:15
Zahra Sobhani , Sara Nikoofal-Sahlabadi, Mohammad Sadegh Amiri, Mahin Ramezani, Seyed Ahmad Emami and Amirhossein Sahebkar*

Discovery of Substituted N-(6-Chloro-3-cyano-4-phenyl-4H-chromen-2-yl)- 2-(4-chloro-phenoxy)-acetamide for Biphasic Anticancer and Anticonvulsant Activities

Volume:15
Divya Chauhan*, Syed Riaz Hashim, Priyanka Rani, Sushil Kumar, Navratan Shrimal, Divya Shastri and Vinit Raj

Preliminary anti-Coxsackie Activity of Novel 1-[4-(5,6-dimethyl(H)- 1H(2H)-benzotriazol-1(2)-yl)phenyl]-3-alkyl(aryl)ureas

Volume:16
Sandra Piras, Paola Corona, Roberta Ibba, Federico Riu, Gabriele Murineddu, Giuseppina Sanna, Silvia Madeddu, Ilenia Delogu, Roberta Loddo* and Antonio Carta*

Fluoroquinolone-3-carboxamide Amino Acid Conjugates: Synthesis, Antibacterial Properties And Molecular Modeling Studies

Volume:15
Riham M. Bokhtia, Siva S. Panda*, Adel S. Girgis, Hitesh H. Honkanadavar, Tarek S. Ibrahim, Amany M. M. Al-Mahmoudy, Riham F. George, Mona T. Kashef, Walid Fayad, Rajeev Sakhuja and Eatedal H. Abdel-Aal

Improvement of the Anticancer Activity of Chlorambucil and Ibuprofen via Calix[4]arene Conjugates

Volume:15
Luis D. Pedro-Hernández, Ulises Organista-Mateos, Luis Isaac Allende-Alarcón, Elena Martínez-Klimova*, Teresa Ramírez-Ápan and Marcos Martínez-García

Design, Synthesis, and Biological Evaluation of Novel C5-Modified Pyrimidine Ribofuranonucleosides as Potential Antitumor or/and Antiviral Agents

Volume:15
Nikolaos Kollatos, Christos Mitsos, Stella Manta, Niki Tzioumaki, Christos Giannakas, Tania Alexouli, Aggeliki Panagiotopoulou, Dominique Schols, Graciela Andrei and Dimitri Komiotis*

Synthetic Dihydropyridines as Novel Antiacanthamoebic Agents

Volume:15
Ayaz Anwar*, Ruqaiyyah Siddiqui, Abdul Hameed, Muhammad Raza Shah and Naveed Ahmed Khan

The Antioxidant, Anticarcinogenic and Antimicrobial Properties of Verbascum thapsus L.

Volume:15
Saman Mahdavi*, Morteza Amiradalat, Marzieh Babashpour, Hosein Sheikhlooei and Mohammad Miransari

ROS Inhibitory Activity and Cytotoxicity Evaluation of Benzoyl, Acetyl, Alkyl Ester, and Sulfonate Ester Substituted Coumarin Derivatives

Volume:15
Uzma Salar, Khalid Mohammed Khan*, Almas Jabeen, Aisha Faheem, Farwa Naqvi, Shakil Ahmed, Erum Iqbal, Farman Ali, Kanwal and Shahnaz Perveen

Novel Benzoxazin-3-one Derivatives: Design, Synthesis, Molecular Modeling, anti-HIV-1 and Integrase Inhibitory Assay

Volume:15
Mahdieh Safakish, Zahra Hajimahdi, Rouhollah Vahabpour, Rezvan Zabihollahi and Afshin Zarghi*

Methoxychalcones: Effect of Methoxyl Group on the Antifungal, Antibacterial and Antiproliferative Activities

Volume:15
Beatriz C. Marques, Mariana B. Santos, Daiane B. Anselmo, Diego A. Monteiro, Eleni Gomes, Marilia F. C. Saiki, Paula Rahal, Pedro L. Rosalen, Janaina C. O. Sardi and Luis O. Regasini

Dairy Safety Prediction Based on Machine Learning Combined with Chemicals

Volume:15
Jiahui Chen, Guangya Zhou, Jiayang Xie, Minjia Wang, Yanting Ding, Shuxian Chen, Sijing Xia, Xiaojun Deng*, Qin Chen* and Bing Niu*

An Increasing Role of Polyphenols as Novel Therapeutics for Alzheimer’s: A Review

Volume:15
Nasiara Karim, Haroon Khan*, Imran Khan, Ouyang Guo, Eduardo Sobarzo Sanchez, Luca Rastrelli and Mohammad Amjad Kamal

New Approaches in Sensing and Targeting Bacterial rRNA A-site

Volume:15
Preethi Parameswaran, Nihar Ranjan* and S.J.S. Flora*

The Assessment of Interleukin-18 on the Risk of Coronary Heart Disease

Volume:15
Weiju Sun, Ying Han, Shuo Yang, He Zhuang, Jingwen Zhang, Liang Cheng* and Lu Fu*

Recent Advancement in Predicting Subcellular Localization of Mycobacterial Protein with Machine Learning Methods

Volume:15
Shi-Hao Li, Zheng-Xing Guan, Dan Zhang, Zi-Mei Zhang, Jian Huang, Wuritu Yang* and Hao Lin*

Applications of Machine Learning Methods in Predicting Nuclear Receptors and their Families

Volume:15
Zi-Mei Zhang, Zheng-Xing Guan, Fang Wang, Dan Zhang and Hui Ding*

iATP: A Sequence Based Method for Identifying Anti-tubercular Peptides

Volume:15
Wei Chen*, Pengmian Feng and Fulei Nie

Synthesis and Cholinesterase Inhibitory Activity of N-Phosphorylated / NTiophosphorylated Tacrine

Volume:15
Maja Przybyłowska, Iwona Inkielewicz-Stepniak, Szymon Kowalski, Krystyna Dzierzbicka*, Sebastian Demkowicz and Mateusz Daśko

NMR: From Molecular Mechanism to its Application in Medical Care

Volume:15
Zhenhong Zhang, Xiaohong Meng, Wei Cui, Syed Sayeed Ahmad, Mohammad A. Kamal and Jinguo Zhang*

Synthesis of Silver Nanoparticles using Euphorbia wallichii Extract and Assessment of their Bio-functionalities

Volume:15
Abdul-Rehman Phull*, Attarad Ali, Akhtar Ali, Sanaullah Abbasi, Muhammad Zia, Muhammad Hassan Khaskheli, Ihsan ul Haq and Mohammad Amjad Kamal

A New Reactive Ketenaminal: Synthesis, Coupling Reaction, Tautomeric Study, Docking and Antimicrobial Evaluation of the Products

Volume:15
Huda K. Mahmoud, Hanadi A. Katouah, Marwa F. Harras and Thoraya A. Farghaly*

Synthesis, Antimicrobial Evaluation and Docking Study of Novel 3,5- Disubstituted-2-Isoxazoline and 1,3,5-Trisubstituted-2-Pyrazoline Derivatives

Volume:15
Ahmed Hussein Ismail, Ahmed Mutanabbi Abdula, Ivan H.R. Tomi, Ali Hussein R. Al-Daraji and Younis Baqi*

Prediction and Analysis of Hub Genes in Renal Cell Carcinoma based on CFS Gene Selection Method Combined with Adaboost Algorithm

Volume:15
Yina Wang, Benrong Zheng, Manbin Xu, Shaoping Cai, Jeong Younseo, Chi Zhang* and Boxiong Jiang*

Novel Furan Coupled Quinoline Diamide Hybrid Scaffolds as Potent Antitubercular Agents: Design, Synthesis and Molecular Modelling

Volume:15
Anantacharya Rajpurohit, Satyanarayan Nayak Devappa*, Lokesh Pathak, Siva Ayyanar, Chidambaram Ramaswamy Rishinaradamangalam and Praveen Shoorapani

Synthesis and Antitrypanosomal Profile of Novel Hydrazonoyl Derivatives

Volume:15
Natália N. Santiago, Giulianna P. de Alcântara, Juliana Silva da Costa, Samir A. Carvalho, Juliana M. C. Barbosa, Kelly Salomão, Solange L. de Castro, Henrique M. G. Pereira and Edson F. da Silva*

New Insights Towards 1,4-Benzodiazepines from Curcumin. Design, Synthesis and Antimicrobial Activities

Volume:15
Othman Hamed*, Oswa Fares, Shaima Taleeb, Ghaleb Adwan, Haythem Saadeh, Shehdeh Jodeh and Manuel Algarra

Synthesis and Assessment of 3-Substituted Phenazines as Novel Antichlamydial Agents

Volume:15
Xiaofeng Bao, Ziyi Liu, Min Ni, Chao Xia, Shunxin Xu, Shengju Yang* and Yu Zhao

2-Mercapto Benzothiazole Derivatives: As Potential Leads for the Diabetic Management

Volume:15
Saeed Ullah, Salma Mirza, Uzma Salar, Shafqat Hussain, Kulsoom Javaid, Khalid Mohammed Khan*, Ruqaiya Khalil, Atia Tul Wahab, Zaheer Ul-Haq, Shahnaz Perveen and M. Iqbal Choudhary

Synthesis of Novel 8-Hydroxyquinoline Derivatives through Mannich Reaction and their Biological Evaluation as Potential Immunomodulatory Agents

Volume:15
Shaheen Faizia*, Tahira Sarfaraz, Saima Sumbul, Almas Jabeen, Sobia Ahsan Halim, Mohammad Ahmed Mesaik and Zaheer Ul-Haq

New Serotoninergic Ligands Containing Indolic and Methyl Indolic Nuclei: Synthesis and in Vitro Pharmacological Evaluation

Volume:15
Elisa Magli, Beatrice Severino*, Angela Corvino, Elisa Perissutti, Francesco Frecentese, Irene Saccone, Flavia Giordano, Marian Castro, Josè Brea, Marian Isabel Loza, Vincenzo Santagada, Giuseppe Caliendo and Ferdinando Fiorino

Synthesis, In vitro α-Glucosidase Inhibitory Potential and Molecular Docking Studies of 2-Amino-1,3,4-Oxadiazole Derivatives

Volume:15
Hayat Ullah, Fazal Rahim*, Muhammad Taha, Raffaqat Hussain, Abdul Wadood, Mohsan Nawaz, Zainul Wahab, Kanwal and Khalid Mohammed Khan

Identification of Novel Functionalized Carbohydrazonamides Designed as Chagas Disease Drug Candidates

Volume:15
Mayara Salles Souza do Nascimento, Vitória Regina Fontes Câmara, Juliana Silva da Costa, Juliana M. Chaves Barbosa, Alessandra Silva Maia Lins, Kelly Salomão, Solange Lisboa de Castro, Samir Aquino Carvalho, Edson Ferreira da Silva and Carlos Alberto Manssour Fraga*

Synthesis, Anticancer Activity on Prostate Cancer Cell Lines and Molecular Modeling Studies of Flurbiprofen-Thioether Derivatives as Potential Target of MetAP (type II)

Volume:15
Özgür Yılmaz, Burak Bayer, Hatice Bekçi, Abdullah Ibrahim Uba, Ahmet Cumaoğlu, Kemal Yelekçi and Ş. Güniz Küçükgüzel*

Synthesis and Evaluation of Glycyrrhetic Acid-aromatic Hybrids as Antiinflammatory Agents

Volume:15
Zhi Chen, Shi-Chao Chen, Bo Li, Yong-An Yang and Jing Zhang*

Design, Synthesis and Evaluation of 8-Thiosubstituted 1,3,7- Trimethylxanthine Hydrazones with In Vitro Neuroprotective and MAO-B Inhibitory Activities

Volume:15
Javor Mitkov, Alexandra Kasabova-Angelova, Magdalena Kondeva-Burdina, Virginia Tzankova, Diana Tzankova, Maya Georgieva and Alexander Zlatkova*

Design of Inhibitors for Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Enzyme of Leishmania mexicana

Volume:15
Krisnna Mariana Aranda Alves, Fábio José Bonfim Cardoso, Kathia Maria Honorio and Fábio Alberto de Molfetta*

Synthesis of N-Substituted Benzamide Derivatives and their Evaluation as Antitumor Agents

Volume:15
Taiping Chen, Hongwu Jiang, Jianjun Zhou, Zicheng Li*, Wencai Huang, Youfu Luo and Yinglan Zhao

Matrine-Family Alkaloids: Versatile Precursors for Bioactive Modifications

Volume:15
Xiao-hua Cai*, Hong-yan Zhang and Bing Xie*

Design, Synthesis and Biological Evaluation of Anti-tuberculosis Agents based on Bedaquiline Structure

Volume:15
Chengjun Wu*, Jinghan Luo, Mengtong Wu, Fanzhen Meng, Zhiqiang Cai, Yu Chen and Tiemin Sun

Anti-Mycobacterial Peroxides: A New Class of Agents for Development Against Tuberculosis

Volume:15
Christiaan W. van der Westhuyzen, Richard K. Haynes, Jenny-Lee Panayides, Ian Wiid and Christopher J. Parkinson*

First Example of Antiparasitic Activity Influenced by Thermochromism: Leishmanicidal Evaluation of 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine Metal Complexes

Volume:15
José M. Méndez-Arriaga*, Itziar Oyarzabal, Álvaro Martín-Montes, Judith García-Rodríguez, Miguel Quirós and Manuel Sánchez-Moreno