Medicinal Chemistry

Editor-in-Chief:

Dimitra Hadjipavlou-Litina
Aristotle University of Thessaloniki
Thessaloniki
Greece

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Articles Ahead of Print

Design, Synthesis, and Evaluation of Isoquinoline Ureas as TRPV1 Antagonists

Volume:15
Nehaben A. Gujarati, Bradley J. Undem and Vijaya L. Korlipara*

2-Mercapto Benzothiazole Derivatives: As Potential Leads for the Diabetic Management

Volume:15
Saeed Ullah, Salma Mirza, Uzma Salar, Shafqat Hussain, Kulsoom Javaid, Khalid Mohammed Khan*, Ruqaiya Khalil, Atia Tul Wahab, Zaheer Ul-Haq, Shahnaz Perveen and M. Iqbal Choudhary

Synthesis of Novel 8-Hydroxyquinoline Derivatives through Mannich Reaction and their Biological Evaluation as Potential Immunomodulatory Agents

Volume:15
Shaheen Faizia*, Tahira Sarfaraz, Saima Sumbul, Almas Jabeen, Sobia Ahsan Halim, Mohammad Ahmed Mesaik and Zaheer Ul-Haq

New Serotoninergic Ligands Containing Indolic and Methyl Indolic Nuclei: Synthesis and in Vitro Pharmacological Evaluation

Volume:15
Elisa Magli, Beatrice Severino*, Angela Corvino, Elisa Perissutti, Francesco Frecentese, Irene Saccone, Flavia Giordano, Marian Castro, Josè Brea, Marian Isabel Loza, Vincenzo Santagada, Giuseppe Caliendo and Ferdinando Fiorino

Synthesis, In vitro α-Glucosidase Inhibitory Potential and Molecular Docking Studies of 2-Amino-1,3,4-Oxadiazole Derivatives

Volume:15
Hayat Ullah, Fazal Rahim*, Muhammad Taha, Raffaqat Hussain, Abdul Wadood, Mohsan Nawaz, Zainul Wahab, Kanwal and Khalid Mohammed Khan

Novel p-Functionalized Chromen-4-on-3-yl Chalcones Bearing Astonishing Boronic Acid Moiety as MDM2 Inhibitor: Synthesis, Cytotoxic Evaluation and Simulation Studies

Volume:15
Richa Kaur Bhatia*, Lakhwinder Singh, Ruchika Garg, Maninder Kaur, Manmohan Yadav, Jitender Madan, Satyavathi Kancherla, Raghuvir R. S. Pissurlenkar and Evans C. Coutinho

Identification of Novel Functionalized Carbohydrazonamides Designed as Chagas Disease Drug Candidates

Volume:15
Mayara Salles Souza do Nascimento, Vitória Regina Fontes Câmara, Juliana Silva da Costa, Juliana M. Chaves Barbosa, Alessandra Silva Maia Lins, Kelly Salomão, Solange Lisboa de Castro, Samir Aquino Carvalho, Edson Ferreira da Silva and Carlos Alberto Manssour Fraga*

Synthesis, Anticancer Activity on Prostate Cancer Cell Lines and Molecular Modeling Studies of Flurbiprofen-Thioether Derivatives as Potential Target of MetAP (type II)

Volume:15
Özgür Yılmaz, Burak Bayer, Hatice Bekçi, Abdullah Ibrahim Uba, Ahmet Cumaoğlu, Kemal Yelekçi and Ş. Güniz Küçükgüzel*

Synthesis and Evaluation of Glycyrrhetic Acid-aromatic Hybrids as Antiinflammatory Agents

Volume:15
Zhi Chen, Shi-Chao Chen, Bo Li, Yong-An Yang and Jing Zhang*

Design, Synthesis and Evaluation of 8-Thiosubstituted 1,3,7- Trimethylxanthine Hydrazones with In Vitro Neuroprotective and MAO-B Inhibitory Activities

Volume:15
Javor Mitkov, Alexandra Kasabova-Angelova, Magdalena Kondeva-Burdina, Virginia Tzankova, Diana Tzankova, Maya Georgieva and Alexander Zlatkova*

Design of Inhibitors for Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Enzyme of Leishmania mexicana

Volume:15
Krisnna Mariana Aranda Alves, Fábio José Bonfim Cardoso, Kathia Maria Honorio and Fábio Alberto de Molfetta*

Synthesis of N-Substituted Benzamide Derivatives and their Evaluation as Antitumor Agents

Volume:15
Taiping Chen, Hongwu Jiang, Jianjun Zhou, Zicheng Li*, Wencai Huang, Youfu Luo and Yinglan Zhao

Thiazole Compounds as Antiviral Agents: An Update

Volume:15
Inder Pal Singh*, Shiv Gupta and Sanjay Kumar

Synthesis of β-Ketosulfone Derivatives As New Non-Cytotoxic Urease Inhibitors In Vitro

Volume:15
Sarosh Iqbal*, Ajmal Khan, Rashid Nazir, Shumaila Kiran, Shahnaz Perveen, Khalid Mohammed Khan* and M. Iqbal Choudhary*

Matrine-Family Alkaloids: Versatile Precursors for Bioactive Modifications

Volume:15
Xiao-hua Cai*, Hong-yan Zhang and Bing Xie*

Design, Synthesis and Biological Evaluation of Anti-tuberculosis Agents based on Bedaquiline Structure

Volume:15
Chengjun Wu*, Jinghan Luo, Mengtong Wu, Fanzhen Meng, Zhiqiang Cai, Yu Chen and Tiemin Sun

The use of Sulfonamide Derivatives in the Treatment of Trypanosomatid Parasites including Trypanosoma cruzi, Trypanosoma brucei, and Leishmania ssp

Volume:15
Cauê Benito Scarim*, Rafael Consolin Chelucci, Jean Leandro dos Santos and Chung Man Chin

Synthesis of New Cyclic Imides Derived From Safrole, Structure- and Ligand-based Approaches to Evaluate Potential New Multitarget Agents Against Species of Leishmania

Volume:15
José Alixandre de Sousa Luis*, Normando Alexandre da Silva Costa, Cristiane Cosmo Silva Luis, Bruno Freitas Lira, Petrônio Filgueiras Athayde-Filho, Tatjana Keesen de Souza Lima, Juliana da Câmara Rocha, Luciana Scotti and Marcus Tullius Scotti

Anti-Mycobacterial Peroxides: A New Class of Agents for Development Against Tuberculosis

Volume:15
Christiaan W. van der Westhuyzen, Richard K. Haynes, Jenny-Lee Panayides, Ian Wiid and Christopher J. Parkinson*

First Example of Antiparasitic Activity Influenced by Thermochromism: Leishmanicidal Evaluation of 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine Metal Complexes

Volume:15
José M. Méndez-Arriaga*, Itziar Oyarzabal, Álvaro Martín-Montes, Judith García-Rodríguez, Miguel Quirós and Manuel Sánchez-Moreno

Hybrids of Coumarin Derivatives as Potent and Multifunctional Bioactive Agents: A Review

Volume:15
Ioannis Fotopoulos and Dimitra Hadjipavlou - Litina*

Design, Synthesis and in vitro Anti-Cancer evaluation of Novel Derivatives of 2-(2-Methyl-1,5-diaryl-1H-pyrrol-3-yl)-2-oxo-N-(pyridin-3-yl)acetamide

Volume:15
Ebrahim Saeedian Moghadam, Farhad Saravani, Ernest Hamel, Zahra Shahsavari, Mohsen Alipour, Saman Hosseinkhani, Seyednasser Ostad and Mohsen Amini*

Inhibitors of Cyclin-Dependent Kinase 1/2 for Anticancer Treatment

Volume:15
Jiajia Mou*, Danghui Chen and Yanru Deng

Synthesis and Biological Evaluation of 5-benzyl-3-pyridyl-1H-1,2,4-triazole Derivatives as Xanthine Oxidase Inhibitors

Volume:15
Song-ye Li , Ting-jian Zhang , Qing-xia Wu, O Kamara Mohamed, Yi Zhang and Fan-hao Meng*

Synthesis and Cytotoxicity Evaluation of Novel Indole Derivatives as Potential Anti-Cancer Agents

Volume:15
Mona Monir Kamel, Mohamed Kamal Abdel-hameid, Hala Bakr ElNassan* and Eman Adel El-Khouly

Structure Activity Relationship of 4-Amino-2-thiopyrimidine Derivatives as Platelet Aggregation Inhibitors

Volume:15
Barbara Cacciari*, Pamela Crepaldi, Chun Yan Cheng, Elena Bossi , Giampiero Spalluto, Stephanie Federico, Kenneth A. Jacobson and Marco Cattaneo

Recent Advances in Therapeutic Applications of Bisbenzimidazoles

Volume:15
Smita Verma , V. Ravichandiran, Nihar Ranjan and S. J.S Flora*

Antiglycation Activity of Triazole Schiff’s Bases Against Fructosemediated Glycation: In vitro and in silico Study

Volume:15
Muniza Shaikh, Salman Siddiqui, Humaira Zafar, Uzma Naqeeb, Fakiha Subzwari, Rehan Imad, Khalid Mohammed Khan and M. Iqbal Choudhary*

Synthesis, Biological Evaluation and Molecular Dynamics Simulation Studies of Novel Diphenyl Ethers

Volume:15
Amol B. Khade, Sidhartha S. Kar, A Cinu Thomas , Ashutosh Tiwari, Mradul Tiwari, K. E. Vandana , Pritesh Bhat, G. Varadaraj Bhat and G. Gautham Shenoy*

New Copper Compounds with Antiplatelet Aggregation Activity

Volume:15
Mirthala Flores-Garcia, Juan Manuel Fernández-G, Cristina Busqueta-Griera, Elizabeth Gomez, Simon Hernandez-Ortega, Jean Christian Daniel Lamothe-Flores, Virginia Gomez-Vidales, Ana Maria Mejia-Dominguez, Eduardo Angles-Cano and Aurora de la Pena-Diaz*

Design and Synthesis of New Sulfonamides–Based Flt3 Inhibitors

Volume:15
Reem Fawaz Abutayeh, Jehad Almaliti and Mutasem O. Taha*

Cytotoxicity, Pro-apoptotic Activity and in silico Studies of Dithiocarbamates and their Structure Based Design and SAR Studies

Volume:15
Syeda Shamila Hamdani, Bilal Ahmad Khan*, Shahid Hameed, Faisal Rashid, Sumera Zaib, Khalil Ahmed, Ehsan Ullah Mughal and Jamshed Iqbal*

Synthesis, Anticancer Evaluation and Synergistic Effects with cisplatin of Novel Palladium Complexes: DNA, BSA Interactions and Molecular Docking Study

Volume:15
Nenad Joksimović, Nenad Janković, Jelena Petronijević, Dejan Baskić, Suzana Popovic, Danijela Todorović, Milan Zarić, Olivera Klisurić, Milan Vraneš, Aleksandar Tot and Zorica Bugarčić*

Design and Synthesis of New Substituted Pyrazolopyridines with Potent Antiproliferative Activity

Volume:15
Vassiliki Giannouli, Nikolaos Lougiakis, Ioannis K. Kostakis, Nicole Pouli*, Panagiotis Marakos, Alexios-Leandros Skaltsounis, David A. Horne, Sangkil Nam, Katerina Gioti and Roxane Tenta

Chemistry, Alpha-glucosidase and Radical Scavenging Properties of Uranyl(VI) Hydrazide Complexes

Volume:15
Parveen Akhter, Uzma Ashiq*, Rifat Ara Jamal, Zara Shaikh, Mohammad Mahroof-Tahir, Mehreen Lateef and Rooma Badar

The Effects of Trifluoromethylated Derivatives on Prostaglandin E2 and Thromboxane A2 Production in Human Leukemic U937 Macrophages

Volume:15
Ivana Beara*, Tatjana Majkić, Stefania Fioravanti, Laura Trulli, Neda Mimica-Dukić, Lucio Pellacani and Luciano Saso

Design, Synthesis, and Biological Evaluation of Novel C5-Modified Pyrimidine Ribofuranonucleosides as Potential Antitumor or/and Antiviral Agents

Volume:15
Nikolaos Kollatos, Christos Mitsos, Stella Manta, Niki Tzioumaki, Christos Giannakas, Tania Alexouli, Aggeliki Panagiotopoulou, Dominique Schols, Graciela Andrei and Dimitri Komioti*

Synthesis of New Hydrazone Derivatives and Evaluation of their Efficacy as Proliferation Inhibitors in Human Cancer Cells

Volume:15
Piotr Świątek*, Jolanta Saczko, Nina Rembiałkowska and Julita Kulbacka

Antibacterial Evaluation of Novel Substituted Cycloheptaindoles in Staphylococcus and Enterococcus Strains

Volume:15
A. Hilgeroth*, K. Yasrebi, S. Suzen, T. Hertlein, K. Ohlsen and M. Lalk

Benzoylthioureas: Design, Synthesis and Antimycobacterial Evaluation

Volume:15
Tiago O. Brito, Lethícia O. Abreu, Karen M. Gomes, Maria C. S. Lourenço, Patricia M. L. Pereira, Sueli F. Yamada-Ogatta, Ângelo de Fàtima, Cesar A. Tisher, Fernando Macedo and Marcelle L. F. Bispo*

The Substantial Improvement of Amphotericin B Selective Toxicity Upon Modification of Mycosamine with Bulky Substituents

Volume:15
Edward Borowski, Natalia Salewska, Joanna Boros-Majewska, Marcin Serocki, Izabela Chabowska, Maria J. Milewska, Dominik Ziętkowski and Sławomir Milewski*

Evaluation of Cytotoxic Potentials of Some Isoindole-1, 3-Dione Derivatives on HeLa, C6 and A549 Cancer Cell Lines

Volume:15
Ayse Tan, Ayse Sahin Yaglioglu, Nurhan Horasan Kishali*, Ertan Sahin and Yunus Kara*

Design and Synthesis of Novel Sulfonamide-Derived Triazoles and Bioactivity Exploration

Volume:14
Shi-Chao He, Hui-Zhen Zhang*, Hai-Juan Zhang, Qing Sun and Cheng-He Zhou

Pyrrolopyrazoles: Synthesis, Evaluation and Pharmacological Screening as Antidepressant Agents

Volume:14
Samar Said Fatahala*, Shahira Nofal, Eman Mahmoud and Rania Helmy Abd El-hameed