Medicinal Chemistry

Editor-in-Chief:

Dimitra Hadjipavlou-Litina
Aristotle University of Thessaloniki
Thessaloniki
Greece

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Ahead of Print Article(s)

In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley?

Volume:14
Ondrej Soukup, Jan Korabecny , David Malinak , Eugenie Nepovimova , Ngoc Lam Pham, Kamil Musilek, Martina Hrabinova , Vendula Hepnarova , Rafael Dolezal , Petr Pavek , Petr Jost , Tereza Kobrlova , Jana Jankockova, Lukas Gorecki , Miroslav Psotka , Thuy Duong Nguyen, Karl Box , Breeze Outhwaite , Martina Ceckova , Ales Sofr , Daniel Jun* and Kamil Kuca*

Synthesis and Structure-Activity Relationship; Exploration of Some Potent Anti-Cancer Phenyl Amidrazone Derivatives

Volume:14
Almeqdad Y. Habashneh, Mustafa M. El-Abadelah, Sanaa K Bardaweel and Mutasem O. Taha*

Xanthine Oxidase Inhibitory and Molecular Docking Studies on Pyrimidones

Volume:13
Humaira Zafar, Sarosh Iqbal, Sumaira Javaid, Khalid M. Khan* and Muhammad I. Choudhary*

Synthesis and Characterization of Thiocarbohydrazones and their Inhibitory Potential Against Ignored Disease Leishmaniasis

Volume:14
Nida Ghouri*, Khalid Mohammed Khan, Arshia, M Iqbal Choudhary and Shahnaz Perveen

New Bis-Pyrazolones as Potential Leads for ROS Inhibition; Environment Friendly Green Synthesis, Structural Characterization, and In Vitro Studies

Volume:14
Sahar Yousuf*, Khalid Mohammed Khan, Uzma Salar, Almas Jabeen, Shakil Ahmed, Munira Taj Muhammad, Aisha Faheem and Shahnaz Perveen

Facile Synthesis, Crystal Structure, DFT Calculation and Biological Activities of 4-(2-fluorophenyl)-3-(3-methoxybenzyl)-1H-1,2,4-triazol-5(4H)-one (5)

Volume:14
Muhammad Saleem, Muhammad Rafiq, Yeon Ki Jeong, Dae Won Cho, Chong-Hyeak Kim, Sung-Yum Seo, Chang-Shik Choi, Seong-Karp Hong and Ki-Hwan Lee*

Construction of an M1GS Ribozyme for Targeted and Rapid mRNA Cleavage; Application on the Ets-2 Oncogene

Volume:14
Chrisavgi Toumpeki, Dimitrios Anastasakis, Ioannis Panagoulias, Vassiliki Stamatopoulou, Tassos Georgakopoulos, Sofia Kallia-Raftopoulos, Athanasia Mouzaki* and Denis Drainas*

Anti-Trypanosoma cruzi Activity in vitro of Phases and Isolated Compounds from Excoecaria lucida Leaves

Volume:14
Cristiane Franca da Silva*, Ania Ochoa Pacheco, Rayane Nogueira Alves, Josean Fechine Tavares, Marcelo Sobral da Silva and Julio Cesar Escalona Arranz

The Synthesis of Chalcones as Anticancer Prodrugs and their Bioactivation in CYP1 Expressing Breast Cancer Cells

Volume:14
Ketan C Ruparelia*, Keti Zeka, Taeeba Ijaz, Dyan N. Ankrett, Nicola E. Wilsher, Paul C. Butler, Hoon L. Tan, Sabahat Lodhi, Avninder S. Bhambra, Gerard A. Potter, Randolph R Arroo and Kenneth J.M. Beresford

Design, Synthesis, Evaluation and Computational Studies of Nipecotic Acid-Acetonaphthone Hybrids as Potential Antiepileptic Agents

Volume:14
Ankit Seth, Piyoosh A. Sharma, Avanish Tripathi, Priyanka K. Choubey, Pavan Srivastava, Prabhash N Tripathi and Sushant Kumar Shrivastava*

Prodrugs For Nitroreductase Based Cancer Therapy- 1 Metabolite Profile, Cell Cytotoxicity and Molecular Modeling Interactions of Nitro Benzamides with Ssap-NtrB

Volume:13
Tugba Gungor, Gulden Yetis, Ferah Cömert Onder, Esra Tokay, Tugba Taşkın Tok, Ayhan Celik, Mehmet Ay* and Feray Kockar

Synthesis and in vitro Antioxidant Activity Study of Some Novel Substituted Piperazinyl Flavone Compounds

Volume:14
Elmas Sari, Paweł Berczynski, Aleksandra Kładna, Irena Kruk, Oya B Dundar, Monika Szymanska and Hassan Y. Aboul-Enein*

Inhibition of Adipogenesis by Thiourea Derivatives

Volume:13
Hina Siddiqui*, Sarah Shafi, Farah Mukhtar, Asma Ejaz, Atta-ur-Rahman and M. Iqbal Choudhary*

Activity of Rifabutin and Hemi-synthetic Derivatives Against Mycobacterium abscessus

Volume:14
Ivy B. Ramis*, Ricardo Figueiredo, Daniela F. Ramos, Priscila C.B. Halicki, Andrea von Groll, Miguel Viveiros, Maria do Ceu Costa and Pedro E.A. da Silva

Synthesis, Characterization and Biological Activities of New Symmetric Bis-1,2,3-Triazoles with Click Chemistry

Volume:13
Fatih Celik*, Yasemin Unver, Burak Barut, Arzu Ozel and Kemal Sancak

Antibacterial Assessment of Heteroaryl, Vinyl, Benzyl, and Alkyl Tetrazole Compounds

Volume:13
Joshua Dudley, Liana Feinn, Heather DeFrancesco, Erica Lindsay, Adiel Coca* and Elizabeth Lewis Roberts

A Novel Method to Synthesize Phosphocreatine and Phosphocreatine Prodrugs

Volume:13
Maria Arkel, Patrizia Garbati, Annalisa Salis, Gianluca Damonte, Nara Liessi, Enrico Adriano, Umberto Benatti, Maurizio Balestrino and Enrico Millo*

Anthranilic Acid Derivatives: Novel Inhibitors of Protein Glycation and the Associated Oxidative Stress in the Hepatocytes

Volume:13
Humera Jahan*, Muhammad Iqbal Choudhary, Amber Atta, Khalid Mohammad Khan and Atta-ur- Rahman

The Quantum Chemical and QSAR Studies on Acinetobacter Baumannii Oxphos Inhibitors

Volume:13
Hakan Sezgin Sayiner*, Afaf A.S. Abdalrahm, Murat A. Başaran, Vasyl Kovalishyn and Fatma Kandemirli*

Day/Night and Summer/Winter Changes in Serum Total Antioxidant Capacity

Volume:13
Armando L. Morera-Fumero*, Pedro Abreu-Gonzalez, Manuel Henry-Benitez, Lourdes Fernandez-Lopez, Estefania Diaz-Mesa, Maria del Rosario Cejas-Mendez and Fernando Guillen-Pino

14-Formyl-15-aryloxy/methoxymatrine and 14-Aryloxymethylidenylmatrine Derivatives as Anti-HIV-1 Agents

Volume:13
Jiulin Huang, Si-Ying Xiang, Min Lv, Liu-Meng Yang, Yuanyuan Zhang, Yong-Tang Zheng and Hui Xu*

Investigation on the Effects of Antimicrobial imidazo[2,1-b]thiazole Derivatives on the Genitourinary Microflora

Volume:13
Rita Morigi, Beatrice Vitali, Cecilia Prata, Rogers A.Ñ. Palomino, Alessandra Graziadio, Alessandra Locatelli, Mirella Rambaldi and Alberto Leoni*

Identification of 1-Aryl-1H-1,2,3-triazoles as Potential New Antiretroviral Agents

Volume:13
Daniel T.G. Gonzaga, Thiago M.L. Souza, Viviane M.M. Andrade, Vitor F. Ferreira and Fernando de C. da Silva*

Biology-Oriented Synthesis (BIOS) of Piperine Derivatives and their Comparative Analgesic and Antiinflammatory Activities

Volume:13
Ammar Yasir, Saiqa Ishtiaq, Muhammad Jahangir, Muhammad Ajaib, Uzma Salar and Khalid Mohammed Khan*

Synthesis and Antimalarial Activity of New Enantiopure Aminoalcoholpyrrolo[ 1,2-a]quinoxalines

Volume:13
Alexia Jonet, Jean Guillon, Catherine Mullié, Anita Cohen, Guillaume Bentzinger, Jérémy Schneider, Nicolas Taudon, Sebastien Hutter, Nadine Azas, Stephane Moreau, Solene Savrimoutou, Patrice Agnamey, Alexandra Dassonville-Klimpt and Pascal Sonnet*

Evaluation of 1,3-benzoxathiol-2-one Derivatives as Potential Antifungal Agents

Volume:13
Luciana Terra, Eliza de L. Chazin, Paola de S. Sanches, Max Saito, Marcus V.N. de Souza, Claudia R.B. Gomes, James L. Wardell, Solange M.S.V. Wardell, Plínio C. Sathler, Gabriela C.C. Silva, Viviane O. Lione, Marcos Kalil, Ana Joffily, Helena C. Castro and Thatyana R.A. Vasconcelos*