Medicinal Chemistry

USP7: Target Validation and Drug Discovery for Cancer Therapy

Volume:14   Issue:1
Pp: 3-18
Jin Zhou*, Jinzheng Wang, Chao Chen, Haoliang Yuan, Xiaoan Wen* and Hongbin Sun*
DOI: 10.2174/1573406413666171020115539

pLoc_bal-mVirus: Predict Subcellular Localization of Multi-Label Virus Proteins by Chou's General PseAAC and IHTS Treatment to Balance Training Dataset

Volume:15   Issue:5
Pp: 496-509
Xuan Xiao*, Xiang Cheng, Genqiang Chen, Qi Mao and Kuo-Chen Chou
DOI: 10.2174/1573406415666181217114710

pLoc_bal-mEuk: Predict Subcellular Localization of Eukaryotic Proteins by General PseAAC and Quasi-balancing Training Dataset

Volume:15   Issue:5
Pp: 472-485
Kuo-Chen Chou*, Xiang Cheng and Xuan Xiao
DOI: 10.2174/1573406415666181218102517

Synthesis of New Isoxazole-, Pyridazine-, Pyrimidopyrazines and Their Anti-Inflammatory and Analgesic Activity

Volume:14   Issue:4
Pp: 356-371
Ameen A. Abu-Hashem* and Mohamed El-Shazly
DOI: 10.2174/1573406414666180112110947

Synthesis, Characterization and Biological Activities of New Symmetric Bis-1,2,3-Triazoles with Click Chemistry

Volume:14   Issue:3
Pp: 230-241
Fatih Celik*, Yasemin Unver, Burak Barut, Arzu Ozel and Kemal Sancak
DOI: 10.2174/1573406413666171120165226

Cell Cycle Arrest and Apoptosis Induction Activity of Nitidine Chloride on Acute Myeloid Leukemia Cells

Volume:14   Issue:1
Pp: 60-66
Peng Li, Shuxin Yan, Xin Dong, Zhao Li, Yu Qiu, Chunyan Ji, Jingru Zhang, Min Ji, Wei Li, Hongchun Wang, Zhi Liu, Xing L. Wang, Jingjing Ye* and Daoxin Ma
DOI: 10.2174/1573406413666170620091543

New Perspectives of Alzheimer Disease Diagnosis – the Most Popular and Future Methods

Volume:14   Issue:1
Pp: 34-43
Katarzyna Pietrzak, Kamila Czarnecka, Elzbieta Mikiciuk-Olasik and Pawel Szymanski*
DOI: 10.2174/1573406413666171002120847

The Role of Vitamin D in Multiple Sclerosis: Biology and Biochemistry, Epidemiology and Potential Roles in Treatment

Volume:14   Issue:2
Pp: 129-143
Steve Simpson Jr*, Ingrid van der Mei and Bruce Taylor
DOI: 10.2174/1573406413666170921143600

Is there a Link between Vitamin B and Multiple Sclerosis?

Volume:14   Issue:2
Pp: 170-180
Natalie Nemazannikova, Kathleen Mikkelsen, Lily Stojanovska, Gregory L. Blatch and Vasso Apostolopoulos*
DOI: 10.2174/1573406413666170906123857

In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley?

Volume:14   Issue:3
Pp: 281-292
Ondrej Soukup, Jan Korabecny, David Malinak, Eugenie Nepovimova, Ngoc L. Pham, Kamil Musilek, Martina Hrabinova, Vendula Hepnarova, Rafael Dolezal, Petr Pavek, Petr Jost, Tereza Kobrlova, Jana Jankockova, Lukas Gorecki, Miroslav Psotka, Thuy D. Nguyen, Karl Box, Breeze Outhwaite, Martina Ceckova, Ales Sorf, Daniel Jun* and Kamil Kuca*
DOI: 10.2174/1573406414666180112105657

Biology-Oriented Synthesis (BIOS) of Piperine Derivatives and their Comparative Analgesic and Antiinflammatory Activities

Volume:14   Issue:3
Pp: 269-280
Ammar Yasir, Saiqa Ishtiaq, Muhammad Jahangir, Muhammad Ajaib, Uzma Salar and Khalid M. Khan*
DOI: 10.2174/1573406413666170623083810

An Update on the Role of Matrix Metalloproteinases in the Pathogenesis of Multiple Sclerosis

Volume:14   Issue:2
Pp: 155-169
Marina Boziki and Nikolaos Grigoriadis*
DOI: 10.2174/1573406413666170906122803

Quinolinic Carboxylic Acid Derivatives as Potential Multi-target Compounds for Neurodegeneration: Monoamine Oxidase and Cholinesterase Inhibition

Volume:14   Issue:1
Pp: 74-85
Nehal A. Khan, Imtiaz Khan, Syed M.A. Abid, Sumera Zaib, Aliya Ibrar, Hina Andleeb, Shahid Hameed* and Jamshed Iqbal*
DOI: 10.2174/1573406413666170525125231

Synthesis, Molecular Modelling and Biological Studies of 3-hydroxypyrane- 4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors

Volume:15   Issue:7
Pp: 755-770
Hajar Sirous, Afshin Fassihi*, Simone Brogi*, Giuseppe Campiani, Frauke Christ, Zeger Debyser, Sandra Gemma, Stefania Butini, Giulia Chemi, Alessandro Grillo, Rezvan Zabihollahi, Mohammad R. Aghasadeghi, Lotfollah Saghaie and Hamid R. Memarian
DOI: 10.2174/1573406415666181219113225

ZnO Nanoparticles Catalyst in the Synthesis of Bioactive Fused Pyrimidines as Anti-breast Cancer Agents Targeting VEGFR-2

Volume:15   Issue:3
Pp: 277-286
Dina H. Dawood, Eman M.H. Abbas, Thoraya A. Farghaly*, Mamdouh M. Ali and Mohammed F. Ibrahim
DOI: 10.2174/1573406414666180912113226

Synthesis and Structural Elucidation of Novel Benzothiazole Derivatives as Anti-tubercular Agents: In-silico Screening for Possible Target Identification

Volume:15   Issue:3
Pp: 311-326
Katharigatta N. Venugopala*, Sandeep Chandrashekharappa, Melendhran Pillay, Subhrajyoti Bhandary, Mahmoud Kandeel, Fawzi M. Mahomoodally, Mohamed A. Morsy, Deepak Chopra, Bandar E. Aldhubiab, Mahesh Attimarad, Osama I. Alwassil, Sree Harsha, Koleka Mlisana and Bharti Odhav
DOI: 10.2174/1573406414666180703121815

Design, Synthesis, and Evaluation of (2-(Pyridinyl)methylene)-1-tetralone Chalcones for Anticancer and Antimicrobial Activity

Volume:14   Issue:4
Pp: 333-343
Maya Z. Gibson, Minh A. Nguyen and Sarah K. Zingales*
DOI: 10.2174/1573406413666171020121244

Managing Neuropathic Pain in Multiple Sclerosis: Pharmacological Interventions

Volume:14   Issue:2
Pp: 106-119
Samuel S. Duffy, Justin G. Lees, Chamini J. Perera and Gila Moalem-Taylor*
DOI: 10.2174/1573406413666170906122508

Quinoline Fluorescent Probes for Zinc – from Diagnostic to Therapeutic Molecules in Treating Neurodegenerative Diseases

Volume:14   Issue:1
Pp: 19-33
Barbara Czaplinska, Ewelina Spaczynska and Robert Musiol*
DOI: 10.2174/1573406413666171002121817

The Inhibition of Polysialyltranseferase ST8SiaIV Through Heparin Binding to Polysialyltransferase Domain (PSTD)

Volume:15   Issue:5
Pp: 486-495
Li-Xin Peng, Xue-Hui Liu, Bo Lu, Si-Ming Liao, Feng Zhou, Ji-Min Huang, Dong Chen, Frederic A. Troy II, Guo-Ping Zhou* and Ri-Bo Huang*
DOI: 10.2174/1573406415666181218101623

New Hybrid Scaffolds based on Hydrazinyl Thiazole Substituted Coumarin; As Novel Leads of Dual Potential; In Vitro α-Amylase Inhibitory and Antioxidant (DPPH and ABTS Radical Scavenging) Activities

Volume:15   Issue:1
Pp: 87-101
Uzma Salar, Khalid M. Khan*, Sridevi Chigurupati, Shazia Syed, Shantini Vijayabalan, Abdul Wadood, Muhammad Riaz, Mehreen Ghufran and Shahnaz Perveen
DOI: 10.2174/1573406414666180903162243

An Expedient Synthesis of CMF-019: (S)-5-Methyl-3-{1-(pentan-3-yl)-2- (thiophen-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamido}hexanoic Acid, a Potent Apelin Receptor (APJ) Agonist

Volume:14   Issue:7
Pp: 688-694
Lena Trifonov, Michal Afri, Krzysztof Palczewski, Edward E. Korshin* and Arie Gruzman*
DOI: 10.2174/1573406414666180412154952

Benzoin Schiff Bases: Design, Synthesis, and Biological Evaluation as Potential Antitumor Agents

Volume:14   Issue:7
Pp: 695-708
Dima A. Sabbah*, Fatima Al-Tarawneh, Wamidh H. Talib, Kamal Sweidan, Sanaa K. Bardaweel, Eveen Al-Shalabi, Haizhen A. Zhong, Ghassan Abu Sheikha, Reema Abu Khalaf and Mohammad S. Mubarak
DOI: 10.2174/1573406414666180412160142

Molecular Interaction and Computational Analytical Studies of Pinocembrin for its Antiangiogenic Potential Targeting VEGFR-2: A Persuader of Metastasis

Volume:14   Issue:6
Pp: 626-640
Neha Sharma, Mala Sharma, Eram Shakeel, Qazi M.S. Jamal, Mohammad A. Kamal, Usman Sayeed, Mohammad K.A. Khan, Mohammad H. Siddiqui, Jamal M. Arif and Salman Akhtar*
DOI: 10.2174/1573406414666180416125121

Synthesis and Antimalarial Activity of New Enantiopure Aminoalcoholpyrrolo[ 1,2-a]quinoxalines

Volume:14   Issue:3
Pp: 293-303
Alexia Jonet, Jean Guillon, Catherine Mullie, Anita Cohen, Guillaume Bentzinger, Jeremy Schneider, Nicolas Taudon, Sebastien Hutter, Nadine Azas, Stephane Moreau, Solene Savrimoutou, Patrice Agnamey, Alexandra Dassonville-Klimpt and Pascal Sonnet*
DOI: 10.2174/1573406413666170726123938