Medicinal Chemistry

Editor-in-Chief:

Dimitra Hadjipavlou-Litina
Aristotle University of Thessaloniki
Thessaloniki
Greece

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Volume:9   Issue: 4
Pp: i-vi

DOI: 10.2174/1573406411309040001

Novel Structurally Varied N-Alkyl 1,4-Dihydropyridines as ABCB1 Inhibitors: Structure-Activity Relationships, Biological Activity and First Bioanalytical Evaluation

Volume:9   Issue: 4
Pp: 487-493
Andreas Hilgeroth, Christiane Baumert, Claudius Coburger, Marianne Seifert, Soren Krawczyk, Cornelius Hempel, Felix Neubauer, Martin Krug, Josef Molnar and Hermann Lage
DOI: 10.2174/1573406411309040002

Synthesis and ABCG2 Inhibitory Activity of Novel Fumitremorgin C Analogs – Specificity and Structure Activity Correlations

Volume:9   Issue: 4
Pp: 494-509
Orsolya Szolomajer-Csikos, Erzsebet Beery, Levente Kosa, Zsuzsanna Rajnai, Marton Jani, Anasztazia Hetenyi, Katalin Tauber Jakab, Peter Krajcsi and Gabor K Toth
DOI: 10.2174/1573406411309040003

Parallel Synthesis of “Click” Chalcones as Antitubulin Agents

Volume:9   Issue: 4
Pp: 510-516
Maleeruk Utsintong, Alberto Massarotti, Antonio Caldarelli and Sewan Theeramunkong
DOI: 10.2174/1573406411309040004

Antitumor Activity of Novel Benzensulfonamide Derivatives in View of their Physiochemical Properties Searched by Principal Component Analysis

Volume:9   Issue: 4
Pp: 517-525
Mariusz Belka, Jaroslaw Slawinski, Lucyna Konieczna, Piotr Kawczak, Tomasz Ciesielski and Tomasz Baczek
DOI: 10.2174/1573406411309040005

Nanosized Tamoxifen-Porphyrin-Glucose [TPG] Conjugate: Novel Selective Anti-breast-cancer Agent, Synthesis and In Vitro Evaluations

Volume:9   Issue: 4
Pp: 526-538
Massoud Amanlou, Zahra Heidari, Seyed Davar Siadat, Mohammad Reza Aghasadeghi, Masoud Ghorbani, Seyed Esmaeil Sadat Ebrahimi, Seyed Mehdi Sadat, Mehdi Hajmohammadi, Ali Jabbari Arabzadeh, Soheila Hekmat, Mahmood Alaei-Beirami, Alireza Azizi Saraji, Hadi Fathi Moghaddam, Mohammad Shafiee Alavidjeh, Seyed Ali Delbaz, Abolfazl Dashtbani-Roozbehani and Mehdi Shafiee Ardestani
DOI: 10.2174/1573406411309040006

Synthesis of Trans-(4-hydroxypyridine)(Ammine)Dichloroplatinum(II) and its Activity in the Human Ovarian Tumour Models

Volume:9   Issue: 4
Pp: 539-544
Narjes Deqnah, Jun Qing Yu, Philip Beale, Keith Fisher and Fazlul Huq
DOI: 10.2174/1573406411309040007

The Synthesis, Structural Study and Anticancer Activity Evaluation of Emodin Derivatives Containing Conjugative Groups

Volume:9   Issue: 4
Pp: 545-552
Wang Wen-Feng, Zhang Feng-Sen, Zhao Wen-Na, Bai Ze-Dong, Yang Hui-Jun, Shao Jing-Wei and Yuan Yao-Feng
DOI: 10.2174/1573406411309040008

Computer Aided Discovery of Potential Anti-inflammatory (S)-naproxen Analogs as COX-2 Inhibitors

Volume:9   Issue: 4
Pp: 553-559
Nulgumnalli Manjunathaiah Raghavendra, Kota Ramakrishna, Vippula Sirisha, Pingli Divya and Alapati Venkateswara Rao
DOI: 10.2174/1573406411309040009

3D-QSAR Modeling of Non-peptide Antagonists for the Human Luteinizing Hormone-releasing Hormone Receptor

Volume:9   Issue: 4
Pp: 560-570
Alain Tundidor-Camba, Julio Caballero and Deysma Coll
DOI: 10.2174/1573406411309040010

Synthesis and Biological Evaluation of Novel Pyrimido[4,5-b]quinoline-2,4- dione Derivatives as MDM2 Ubiquitin Ligase Inhibitors

Volume:9   Issue: 4
Pp: 581-587
Xiaoxue Dou, Xin Li, Liu Tao, Chunqi Hu, Lei Zhang, Qiaojun He, Bo Yang and Yongzhou Hu
DOI: 10.2174/1573406411309040012

Synthesis of Benzophenonehydrazone Schiff Bases and their In Vitro Antiglycating Activities

Volume:9   Issue: 4
Pp: 588-595
Khalid Mohammed Khan, Fazal Rahim, Nida Ambreen, Muhammad Taha, Momin Khan, Humaira Jahan, Najeebullah, Azizuddin Shaikh, Sarosh Iqbal, Shahnaz Perveen and Muhammad Iqbal Choudhary
DOI: 10.2174/1573406411309040013

New Quinolinyl–1,3,4–Oxadiazoles: Synthesis, In Vitro Antibacterial, Antifungal and Antituberculosis Studies

Volume:9   Issue: 4
Pp: 596-607
Rahul V. Patel, Premlata Kumari and Kishor H. Chikhalia
DOI: 10.2174/1573406411309040014

In-Silico Analysis of Chromone Containing Sulfonamide Derivatives as Human Carbonic Anhydrase Inhibitors

Volume:9   Issue: 4
Pp: 608-616
Zaheer Ul-Haq, Saman Usmani, Uzma Mahmood, Mariya al-Rashida and Ghulam Abbas
DOI: 10.2174/1573406411309040015

6-Chloro-7-methyl-3', 4'-dimethoxyflavone – a Potent Selective COX-2 Inhibitor

Volume:9   Issue: 4
Pp: 617-623
Rafia Bashir, Kalim Javed, Shafiya Yaseen, Syed Ovais, Pooja Rathore, Hinna Hamid, M. S. Alam, Mohammed Samim, Surender Singh and Vinod Nair
DOI: 10.2174/1573406411309040016

Investigations Towards New Antidiabetic Drugs from Fungal Endophytes Associated with Salvadora Oleoides Decne

Volume:9   Issue: 4
Pp: 624-632
Seema Dhankhar, Sandeep Dhankhar and Jaya Parkash Yadav
DOI: 10.2174/1573406411309040017