Medicinal Chemistry

Editor-in-Chief:

Dimitra Hadjipavlou-Litina
Aristotle University of Thessaloniki
Thessaloniki
Greece

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Selective Inhibition of Inducible Nitric Oxide Synthase by Derivatives of Acetamidine

Volume:8   Issue:6
Pp: 991-995
Cristina Maccallini, Antonia Patruno, Alessandra Ammazzalorso, Barbara De Filippis, Marialuigia Fantacuzzi, Sara Franceschelli, Letizia Giampietro, Simona Masella, Maria Luisa Tricca and Rosa Amoroso
DOI: 10.2174/1573406411208060991

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Transient Injury-Dependent Up-Regulation of CD105 and its Specific Targeting with an Anti-Vascular Anti-Mouse Endoglin-Nigrin b Immunotoxin

Volume:8   Issue:6
Pp: 996-1002
Raquel Munoz, Yolanda Arias, Jose Miguel Ferreras, Pilar Jimenez, Maria Angeles Rojo, Carmelo Bernabeu, Damian Cordoba-Diaz and Tomas Girbes
DOI: 10.2174/1573406411208060996

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Antimitotic Activity on Sea Urchin Embryonic Cells of Seven Antiparasitic Morita-Baylis-Hillman Adducts: A Potential New Class of Anticancer Drugs

Volume:8   Issue:6
Pp: 1003-1011
Jocelmo C. A. Leite, Claudio G. L. Junior, Fabio P. L. Silva, Suervy C.O. Sousa, Mario L. A. A. Vasconcellos and Luis F. Marques-Santos
DOI: 10.2174/1573406411208061003

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Synthesis, SAR and Biological Evaluation of Natural and Non-natural Hydroxylated and Prenylated Xanthones as Antitumor Agents

Volume:8   Issue:6
Pp: 1012-1025
Xiaojin Zhang, Xiang Li, Suofu Ye, Yu Zhang, Lei Tao, Yuan Gao, Dandan Gong, Meiyang Xi, Huyan Meng, Mingqian Zhang, Wenlei Gao, Xiaoli Xu, Qinglong Guo and Qidong You
DOI: 10.2174/1573406411208061012

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Impact of Clozapine, N-Desmethylclozapine and Chlorpromazine on Thromboxane Production in Vitro

Volume:8   Issue:6
Pp: 1032-1038
Hubertus Himmerich, Luise Schmidt, Susen Becker, Linda Kortz, Jeremias Schonherr, Roland Mergl, Katrin Bauer, Ulrich Sack, Abigail J. Sheldrick, Joachim Thiery and Uta Ceglarek
DOI: 10.2174/1573406411208061032

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Synthesis and Biological Evaluation of New Sulfonamide Derivatives as Potential Anti-Trypanosoma cruzi Agents

Volume:8   Issue:6
Pp: 1039-1044
Virgilio Bocanegra-Garcia, Juan Carlos Villalobos-Rocha, Benjamin Nogueda-Torres, Maria Edith Lemus- Hernandez, Argelia Camargo-Ordonez, Ninfa Maria Rosas-Garcia and Gildardo Rivera
DOI: 10.2174/1573406411208061039

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Molecular Features for Antitrypanosomal Activity of Thiosemicarbazones Revealed by OPS-PLS QSAR Studies

Volume:8   Issue:6
Pp: 1045-1056
Norka Beatriz Huaman Lozano, Vinicius Goncalves Maltarollo, Karen Cacilda Weber, Kathia Maria Honorio, Rafael Victorio Carvalho Guido, Adriano Defini Andricopulo and Alberico Borges Ferreira Da Silva
DOI: 10.2174/1573406411208061045

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Structure-Based Design, Synthesis and Molecular Modeling Studies of Thiazolyl Urea Derivatives as Novel Anti-Parkinsonian Agents

Volume:8   Issue:6
Pp: 1057-1068
Faizul Azam, Medapati Vijaya Vara Prasad, Neelaveni Thangavel, Anil Kumar Shrivastava and Govind Mohan
DOI: 10.2174/1573406411208061057

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Design, Synthesis and Anticonvulsant Activity Evaluation of 7-Substituted –[1,2,4]-Triazolo[4,3-f]Pyrimidine Derivatives

Volume:8   Issue:6
Pp: 1076-1083
Li-Ping Guan, Xin Sui, Yue Chang, Zheng-Shun Yan, Guo-Zhong Tong and You-Le Qu
DOI: 10.2174/1573406411208061076

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3D-QSAR and Docking Studies on a Series of Benzothiadiazine Derivatives as Genotype 1 HCV Polymerase Inhibitors

Volume:8   Issue:6
Pp: 1099-1107
Vaishali M. Patil, Satya Prakash Gupta, Subeer Samanta and Neeraj Masand
DOI: 10.2174/1573406411208061099

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QSAR Study On 5-Lipoxygenase Inhibitors Based on Support Vector Machine

Volume:8   Issue:6
Pp: 1108-1116
Bing Niu, Qiang Su, Xiaochen Yuan, Wencong Lu and Juan Ding
DOI: 10.2174/1573406411208061108

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3D QSAR Pharmacophore Modeling for c-Met Kinase Inhibitors

Volume:8   Issue:6
Pp: 1117-1125
Dandan Huang, Xiaoyun Zhu, Chunlei Tang, Yicheng Mei, Wei Chen, Baowei Yang, Jing Han, Hai Qian and Wenlong Huang
DOI: 10.2174/1573406411208061117

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Design, Synthesis and Antihistamine Evaluations of Several N-hydroxyalkyl Desloratadine Analogues

Volume:8   Issue:6
Pp: 1126-1132
Yan Lin, Yue Wang, Li-feng Sima, Dong-hua Wang, Li-gong Chen and Lei Li
DOI: 10.2174/1573406411208061126

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Identification of Small Molecule Sulfonic Acids as Ecto-5'-Nucleotidase Inhibitors

Volume:8   Issue:6
Pp: 1133-1139
Rabia Raza, Aamer Saeed, Joanna Lecka, Jean Sevigny and Jamshed Iqbal
DOI: 10.2174/1573406411208061133

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Looking for New Targets: Simple Coumarins as Antibacterial Agents

Volume:8   Issue:6
Pp: 1140-1145
Maria Joao Matos, Saleta Vazquez-Rodriguez, Lourdes Santana, Eugenio Uriarte, Cristina Fuentes-Edfuf, Ysabel Santos and Angeles Munoz-Crego
DOI: 10.2174/1573406411208061140

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New Cathepsin D Inhibitor Library Utilizing Hydroxyethyl Isosteres with Cyclic Tertiary Amines

Volume:8   Issue:6
Pp: 1146-1154
Rose M. McConnell, Kalyani Inapudi, Naveen Kadasala, Karthika Yarlagadda, Priya Velusamy, Matthew S. McConnell, Adam Green, Carol Trana, Kelley Sayyar and James S. McConnell
DOI: 10.2174/1573406411208061146

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In Silico Prediction of Novel Inhibitors of the DNA Binding Activity of FoxG1

Volume:8   Issue:6
Pp: 1155-1162
Syam Bhuvanachandran Nair, Shaik Mahammad Abdul Fayaz and Rajanikant Golgodu Krishnamurthy
DOI: 10.2174/1573406411208061155

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Evaluating the Diagnostic and Chemotherapeutic Potential of Vancomycin- Derived Imaging Conjugates

Volume:8   Issue:6
Pp: 1163-1170
Sumbla Sheikh, Alexander Sturzu, Uwe Klose, Hartmut Echner, Martin Deeg, Thomas Nagele, Marius Horger, Christian Schwentner, Ulrike Ernemann, Wolfgang Voelter and Stefan Heckl
DOI: 10.2174/1573406411208061163

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Description of High Purity and High Specific Activity of [11C]Choline Synthesis Using TRACERlab FXc Module, and Detailed Report of Quality Controls

Volume:8   Issue:6
Pp: 1182-1189
Giorgio Biasiotto, Francesco Bertagna, Ugo Biasiotto, Carlo Rodella, Giovanni Bosio, Luigi Caimi, Giovanni Bettinsoli and Raffaele Giubbini
DOI: 10.2174/1573406411208061182

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Synthesis, Crystal Structure and Anti-HIV Activity of 2- Adamantyl/adamantylmethyl-5-aryl-1,3,4-oxadiazoles

Volume:8   Issue:6
Pp: 1190-1197
Mahmood-ul-Hassan Khan, Tashfeen Akhtar, Najim A. Al-Masoudi, Helen Stoeckli-Evans and Shahid Hameed
DOI: 10.2174/1573406411208061190

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