Medicinal Chemistry

Editor-in-Chief:

Dimitra Hadjipavlou-Litina
Aristotle University of Thessaloniki
Thessaloniki
Greece

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A TRIBUTE TO A LIVING LEGEND (Special Issue in Honor of the 70th Birthday of Dr. Atta-ur-Rahman.) promotion: free to download

Volume:8   Issue:5
Pp: i-i
William J. Hoekstra, Andreas Hilgeroth, Kuo-Chen Chou, Istvan Toth, Adam McCluskey, Ming-Rong Zhang and Paul Cos
DOI: 10.2174/157340641120805000i

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Synthesis of 5-Methyl-1,3-oxathiolane-based Nucleoside Analogues as Potential Antiviral Agents

Volume:8   Issue:5
Pp: 769-778
Silvia Franchini, Annalisa Tait, Claudia Sorbi and Livio Brasili
DOI: 10.2174/157340612802084162

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Synthesis and In Vitro Biological Evaluation of Novel Pyrazole Derivatives as Potential Antitumor Agents

Volume:8   Issue:5
Pp: 779-788
Michael S. Christodoulou, Nikolas Fokialakis, Sangkil Nam, Richard Jove, Alexios-Leandros Skaltsounis and Serkos A. Haroutounian
DOI: 10.2174/157340612802084252

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Synthesis and Immunomodulation of Human Lymphocyte Proliferation and Cytokine (Interferon-γ) Production of Four Novel Leflunomide Analogues

Volume:8   Issue:5
Pp: 799-804
Seyed Adel Moalem, Farzin Hadizadeh, Elham Saber Farimani, Maryam Rameshrad and Maryam Allahyari
DOI: 10.2174/157340612802084180

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Poly (D,L-lactic-co-glycolide) Nanoparticles for the Improved Therapeutic Efficacy of All-trans-retinoic Acid: A Study of Acute Myeloid Leukemia (AML) Cell Differentiation In Vitro

Volume:8   Issue:5
Pp: 805-810
Aswathy Mary Simon, Sankar Jagadeeshan, Emimol Abraham, Ashalatha Akhilandeshwaran, Jisha J. Pillai, Nisha Asok Kumar, Asha Nair Sivakumari and Gopalakrishnapillai Sankaramangalam Vinod Kumar
DOI: 10.2174/157340612802084333

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The Efficacy of Conceptual DFT Descriptors and Docking Scores on the QSAR Models of HIV Protease Inhibitors

Volume:8   Issue:5
Pp: 811-825
Hemant Kumar Srivastava, Chinmayee Choudhury and G. Narahari Sastry
DOI: 10.2174/157340612802084351

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Hexapeptide Functionality of Cellulose as NS3 Protease Inhibitors

Volume:8   Issue:5
Pp: 826-830
Medhat Ibrahim, Noha A. Saleh, Wael M. Elshemey and Anwar A. Elsayed
DOI: 10.2174/157340612802084144

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Anti HIV-1 Agents 6. Synthesis and Anti-HIV-1 Activity of Indolyl Glyoxamides

Volume:8   Issue:5
Pp: 831-833
Yi Wang, Ning Huang, Xiang Yu, Liu-Meng Yang, Xiao-Yan Zhi, Yong-Tang Zheng and Hui Xu
DOI: 10.2174/157340612802084270

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Synthesis, Characterization, Biological Evaluation and Docking of Coumarin Coupled Thiazolidinedione Derivatives and its Bioisosteres as PPARγ Agonists

Volume:8   Issue:5
Pp: 834-845
Shubhanjali Shukla, Pankaj Kumar, Nirupam Das, N.S. Hari Narayana Moorthy, Sushant Kumar Shrivastava, Piyush Trivedi and Radhey Shyam Srivastava
DOI: 10.2174/157340612802084388

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Metronidazole Esters: A New Class of Antiglycation Agents

Volume:8   Issue:5
Pp: 846-852
Aurang Zeb, Imran Malik, Saima Rasheed, Muhammad Iqbal Choudhary and Fatima Z. Basha
DOI: 10.2174/157340612802084360

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In silico Based Structural Analysis of Some Piperidine Analogs as Farnesyltransferase Inhibitors

Volume:8   Issue:5
Pp: 853-864
Narayana Subbiah Hari Narayana Moorthy, Sergio F. Sousa, Maria J. Ramos and Pedro A. Fernandes
DOI: 10.2174/157340612802084171

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Synthesis of 5,6-Dichloroindan-1-Acids and their Tetrazolyl Derivatives as Analgesic and Anti-inflammatory Agents

Volume:8   Issue:5
Pp: 874-882
Rajib Kumar Pal, Hasina Yasmin, Lutfun Nahar, Bidyut Kanti Datta, Abul Kalam Azad Chowdhury, Joydeb Kumar Kundu, Sitesh Chandra Bachar and Satyajit Dey Sarker
DOI: 10.2174/157340612802084234

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Influence of Usnic Acid and its Derivatives on the Activity of Mammalian Poly(ADP-ribose)polymerase 1 and DNA Polymerase β

Volume:8   Issue:5
Pp: 883-893
Alexandra Zakharenko, Dmitry Sokolov, Olga Luzina, Maria Sukhanova, Svetlana Khodyreva, Olga Zakharova, Nariman Salakhutdinov and Olga Lavrik
DOI: 10.2174/157340612802084225

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Quantifying the Structural Requirements for Designing Newer FLT3 Inhibitors

Volume:8   Issue:5
Pp: 913-927
Rajiv Kumar Kar, Priyanka Suryadevara, Rajesh Roushan, Ganesh Chandra Sahoo, Manas Ranjan Dikhit and Pradeep Das
DOI: 10.2174/157340612802084153

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Anti-diabetic Effect of Ginsenoside Rb3 in Alloxan-induced Diabetic Mice

Volume:8   Issue:5
Pp: 934-941
Qi Tao Bu, Wei Yun Zhang, Quan Cheng Chen, Cheng Zhong Zhang, Xiao Jie Gong, Wen Cong Liu, Wei Li and Yi Nan Zheng
DOI: 10.2174/157340612802084199

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Antioxidant Activity of New Benzo[de]quinolines and Lactams: 2DQuantitative Structure-Activity Relationships

Volume:8   Issue:5
Pp: 942-946
Alina Ghinet, Amaury Farce, Souhila Oudir, Jean Pommery, Joseph Vamecq, Jean-Pierre Henichart, Benoit Rigo and Philippe Gautret
DOI: 10.2174/157340612802084216

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Biological Evaluation of Mechlorethamine-Pt(II) Complex, Part II: Antimicrobial Screening and Lox Study of the Complex and its Ligand

Volume:8   Issue:5
Pp: 947-952
Ivana D. Radojevic, Zorica D. Petrovic, Ljiljana R. Comic, Dusica Simijonovic, Vladimir P. Petrovic and Dimitra Hadjipavlou-Litina
DOI: 10.2174/157340612802084315

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Design, Synthesis and Protection Against Pentylenetetrazole-induced Seizure of N-aryl Derivatives of the Phthalimide Pharmacophore

Volume:8   Issue:5
Pp: 953-963
Asghar Davood, Hamed Shafaroodi, Mohsen Amini, Alireza Nematollahi, Mehrshad Shirazi and Maryam Iman
DOI: 10.2174/157340612802084289

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Synthesis, Antidiabetic and Hypolipidemic Activities of New Diethylamine and Triethoxysilyl Derivatives of Tolbutamide on Rats

Volume:8   Issue:5
Pp: 964-969
Abbas Ahmadi, Mohsen Khalili, Seyedsobhan Seyedhoseyni, Ehsan Maadi Roudsari and Babak Nahri-Niknafs
DOI: 10.2174/157340612802084261

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Design of Novel Dihydroxynaphthoic Acid Inhibitors of Plasmodium Falciparum Lactate Dehydrogenase

Volume:8   Issue:5
Pp: 970-984
Eugene Megnassan, Melalie Keita, Cecile Bieri, Akori Esmel, Vladimir Frecer and Stanislav Miertus
DOI: 10.2174/157340612802084324

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A Novel and Facile Synthetic Approach for Tasigna

Volume:8   Issue:5
Pp: 985-989
Xiaoyan Pan, Wen Lu, Pengfei Li, Fang Wang, Chen Wang, Zhigang Hu and Jie Zhang
DOI: 10.2174/157340612802084207

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