Medicinal Chemistry


Dimitra Hadjipavlou-Litina
Aristotle University of Thessaloniki


The Survey of the Use of QSAR Methods to Determine Intestinal Absorption and Oral Bioavailability During Drug Design

Volume:10   Issue:5
Pp: 441-448
Fredson Torres Silva and Gustavo H.G. Trossini
DOI: 10.2174/1573406410666140415122115

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Development, Validation and Application of an LC-MS/MS Bioanalytical Method for the Quantification of GF449, A Novel 5-HT1A Agonist, in Rat Plasma and Brain

Volume:10   Issue:5
Pp: 449-459
Silvia Franchini, Laura Taddia, Diego Pinetti, Gianluca Carnevale and Livio Brasili
DOI: 10.2174/1573406409666131128150507

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Synthesis, Pharmacological Activity and Molecular Modeling of 1-Aryl-7- hydroxy-2,3-dihydroimidazo[1,2-a]pyrimidine-5(1H)-ones and their 6-Substituted Derivatives

Volume:10   Issue:5
Pp: 460-475
Marzena Rzadkowska, Elzbieta Szacon, Agnieszka A. Kaczor, Sylwia Fidecka, Ewa Kedzierska and Dariusz Matosiuk
DOI: 10.2174/1573406409666131128145844

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Synthesis and In vitro Analysis of Novel Dihydroxyacetophenone Derivatives with Antimicrobial and Antitumor Activities

Volume:10   Issue:5
Pp: 476-483
Ana Maria Zbancioc, Anca Miron, Cristina Tuchilus, Pincu Rotinberg, Cosmin Teodor Mihai, Ionel I. Mangalagiu and Gheorghita Zbancioc
DOI: 10.2174/15734064113096660070

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Synthesis and Dual D2 and 5-HT1A Receptor Binding Affinities of 7-piperazinyl and 7-piperidinyl-3,4-dihydroquinazolin-2(1H)-ones

Volume:10   Issue:5
Pp: 484-496
Nisar Ullah
DOI: 10.2174/15734064113096660046

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Discovery of Aroyl Piperazine Derivatives as IKr & IKs Dual Inhibitors for Cardiac Arrhythmia Treatment

Volume:10   Issue:5
Pp: 497-505
Xiaoke Guo, Haopeng Sun, Lvpei Du, Lu Huang, Jing Xu, Yingying Zhu, Peng Yu, Xiaojin Zhang, Yiqun Tang and Qidong You
DOI: 10.2174/1573406409666131128144755

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Synthesis and Preliminary Biological Evaluation of Polyamine-aniline Acridines as P-glycoprotein Inhibitors

Volume:10   Issue:5
Pp: 506-511
Jianhong Wang, Pengfei Cheng, Tianwei Luo, Zhaoyi Wang, Yahong Zhang and Jin Zhao
DOI: 10.2174/15734064113096660052

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An Efficient Ionic Liquid Mediated Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Piperidone Embedded α ,β-Unsaturated Ketones

Volume:10   Issue:5
Pp: 512-520
Yalda Kia, Hasnah Osman, Raju Suresh Kumar, Vikneswaran Murugaiyah, Alireza Basiri, Kooi Yeong Khaw and Mohd. Mustaqim Rosli
DOI: 10.2174/15734064113096660056

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Synthesis, Antioxidant, Anticancer and Antiviral Activities of Novel Quinoxaline Hydrazone Derivatives and their Acyclic C-Nucleosides

Volume:10   Issue:5
Pp: 521-532
Alaa A. El-Tombary and Soad A.M. El-Hawash
DOI: 10.2174/15734064113096660069

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Synthesis of Aryl-Substituted Naphthalenoids as Potent Topoisomerase Inhibitors

Volume:10   Issue:5
Pp: 533-539
Yan Shen, Wang Chen, Zhenyu Li and Yuemao Shen
DOI: 10.2174/15734064113096660048

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