Medicinal Chemistry

Editor-in-Chief:

Dimitra Hadjipavlou-Litina
Aristotle University of Thessaloniki
Thessaloniki
Greece

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Graphical Abstracts open Access plus

Volume:10   Issue: 1
Pp: i-iv

DOI: 10.2174/157340641001131226100523

Foreword open Access plus

Volume:10   Issue: 1
Pp: 1-1
Atta-ur-Rahman
DOI: 10.2174/157340641001131226101323

Bioavailability of Endomorphins and the Blood-brain Barrier- A Review open Access plus

Volume:10   Issue: 1
Pp: 2-17
Renata Perlikowska and Anna Janecka
DOI: 10.2174/15734064113099990040

Ramoplanin Imaging Conjugates – Synthesis and Evaluation open Access plus

Volume:10   Issue: 1
Pp: 18-26
Sumbla Sheikh, Alexander Sturzu, Hubert Kalbacher, Uwe Klose, Thomas Nagele, Bushra Amin, Martin Deeg, Marius Horger, Ulrike Ernemann and Stefan Heckl
DOI: 10.2174/157340641001131226121133

Anti-Neoplastic Activity of 1,3-Diaza-2-Functionalized-Adamantan-6-One Compounds Against Melanoma Cells open Access plus

Volume:10   Issue: 1
Pp: 27-37
Yifat Sharabi-Ronen, Shlomo Levinger, Miri Ben-Dahan Lellouche and Amnon Albeck
DOI: 10.2174/15734064113099900002

Design, Synthesis and Biological Evaluation of Novel Non-peptide Boronic Acid Derivatives as Proteasome Inhibitors open Access plus

Volume:10   Issue: 1
Pp: 38-45
Jiankang Zhang, Luqing Shen, Jincheng Wang, Peihua Luo and Yongzhou Hu
DOI: 10.2174/15734064113099990006

Structural Elucidation of Unique Inhibitory Activities of Two Thiazolo[ 4,5-d]pyrimidines Against Epidermal Growth Factor Receptor (EGFR): Implications for Successful Drug Design open Access plus

Volume:10   Issue: 1
Pp: 46-58
Petar M. Mitrasinovic
DOI: 10.2174/157340641001131226122124

Effect of Stilbene and Chalcone Scaffolds Incorporation in Clofibric Acid on PPARα  Agonistic Activity open Access plus

Volume:10   Issue: 1
Pp: 59-65
Letizia Giampietro, Alessandra D’Angelo, Antonella Giancristofaro, Alessandra Ammazzalorso, Barbara De Filippis, Mauro DiMatteo, Marialuigia Fantacuzzi, Pasquale Linciano, Cristina Maccallini and Rosa Amoroso
DOI: 10.2174/157340641001131226123613

Computer-aided Design, Synthesis, and Biological Evaluation of 5- Substituted Aminomethylenepyrimidine-2,4,6-Triones as H1 Antihistaminic Agents (Part2) open Access plus

Volume:10   Issue: 1
Pp: 66-73
Rasha Y. Elbayaa
DOI: 10.2174/15734064113099990032

Alkyl Caffeates as Anti-Helicobacter Pylori and Scavenger of Oxidants Produced by Neutrophils open Access plus

Volume:10   Issue: 1
Pp: 74-80
Luana Chiquetto Paracatu, Cibele Bonacorsi, Carolina Maria Quinello Gomes de Farias, Ana Carolina Nazaré, Maicon Segalla Petrônio, Luiz Octávio Regasini, Dulce Helena Siqueira Silva, Maria Stella Gonçalves Raddi, Luiz Marcos da Fonseca and Valdecir Farias Ximenes
DOI: 10.2174/157340641001131226125042

Ligustrazine Derivatives. Part 8: Design, Synthesis, and Preliminary Biological Evaluation of Novel Ligustrazinyl Amides as Cardiovascular Agents open Access plus

Volume:10   Issue: 1
Pp: 81-89
Zhenyu Li, Fang Yu, Lei Cui, Wenmin Chen, Shouxun Wang, Peng Zhan, Yuemao Shen and Xinyong Liu
DOI: 10.2174/157340641130900042

Approaches to a Multitargeting Drug Development: First Profiled 3- Ethoxycarbonyl-1-aza-9-oxafluorenes Representing a Perspective Compound Class Targeting Alzheimer Disease Relevant Kinases CDK1, CDK5 and GSK-3β open Access plus

Volume:10   Issue: 1
Pp: 90-97
Andreas Hilgeroth, Volkmar Tell, Steffi Kramer, Frank Totzke and Christoph Schachtele
DOI: 10.2174/157340641001131226141606

A Comprehensive Ligand Based Mapping of the σ2 Receptor Binding Pocket open Access plus

Volume:10   Issue: 1
Pp: 98-121
Derek J. Rhoades, David H. Kinder and Tarek M. Mahfouz
DOI: 10.2174/1573406409999131119103621