Medicinal Chemistry

Editor-in-Chief:

Dimitra Hadjipavlou-Litina
Aristotle University of Thessaloniki
Thessaloniki
Greece

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Abstract Ahead of Print

Study of interactions energies between residues of the active site of Hsp90 and the geldanamycin analogues using Quantum Mechanics/Molecular Mechanics (QM/MM) methods

Volume:15
Ricardo Vivas-Reyes, Alejandro Morales-Bayuelo, Carlos Gueto, Juan C. Droso, Johana Márquez, Rosa Baldiris, Maicol Ahumedo, Catalina Vivas-Gomez and Dilia Aparicio

Methoxychalcones: Effect of Methoxyl Group toward Antifungal, Antibacterial and Antiproliferative Activities

Volume:15
Beatriz C. Marques, Mariana B. Santos, Daiane B. Anselmo, Diego A. Monteiro, Eleni Gomes, Marilia F. C. Saiki, Paula Rahal, Pedro L. Rosalen, Janaina C. O. Sardi and Luis O. Regasini

Novel p-Functionalized Chromen-4-on-3-yl Chalcones Bearing Astonishing Boronic Acid Moiety as MDM2 Inhibitor: Synthesis, Cytotoxic Evaluation and Simulation Studies

Volume:15
Richa Kaur Bhatia*, Lakhwinder Singh, Ruchika Garg, Maninder Kaur, Manmohan Yadav, Jitender Madan, Satyavathi Kancherla, Raghuvir R. S. Pissurlenkar and Evans C. Coutinho

Synthetic Dihydropyridines as Novel Antiacanthamoebic Agents

Volume:15
Ayaz Anwar*, Ruqaiyyah Siddiqui, Abdul Hameed, Muhammad Raza Shah and Naveed Ahmed Khan

A new reactive Ketenaminal: Synthesis, coupling reaction, tautomeric study, docking and antimicrobial evaluation of the products

Volume:15
Huda K. Mahmoud, Hanadi A. Katouah, Marwa F. Harras and Thoraya A. Farghaly*

Synthesis and Cholinesterase Inhibitory Activity of N-Phosphorylated / N-Tiophosphorylated Tacrine

Volume:15
Maja Przybyłowska, Iwona Inkielewicz-Stepniak, Szymon Kowalski, Krystyna Dzierzbicka*, Sebastian Demkowicz and Mateusz Daśko

4-Aminocoumarin based aroylthioureas as potential jack bean urease inhibitors; Synthesis, enzyme inhibitory kinetics and docking studies

Volume:15
Tanzeela Abdul Fattah, Aamer Saeed, Zaman Ashraf, Qamar Abbas, Pervaiz Ali Channar, Fayaz Ali Larik and Mubashir Hassan

Synthesis of N-Substituted Benzamide Derivatives and their Evaluation as Antitumor Agents

Volume:15
Taiping Chen, Hongwu Jiang, Jianjun Zhou, Zicheng Li*, Wencai Huang, Youfu Luo and Yinglan Zhao

Synthesis and Antitrypanosomal Profile of Novel Hydrazonoyl Derivatives

Volume:15
Natália N. Santiago, Giulianna P. de Alcântara, Juliana Silva da Costa, Samir A. Carvalho, Juliana M. C. Barbosa, Kelly Salomão, Solange L. de Castro, Henrique M. G. Pereira and Edson F. da Silva*

Synthesis and Assessment of 3-Substituted Phenazines as Novel Antichlamydial Agents

Volume:15
Xiaofeng Bao, Ziyi Liu, Min Ni, Chao Xia, Shunxin Xu, Shengju Yang* and Yu Zhao

Identification of novel functionalized carbohydrazonamides designed as Chagas disease drug candidates

Volume:15
Mayara Salles Souza do Nascimento, Vitória Regina Fontes Câmara, Juliana Silva da Costa, Juliana M. Chaves Barbosa, Alessandra Silva Maia Lins, Kelly Salomão, Solange Lisboa de Castro, Samir Aquino Carvalho, Edson Ferreira da Silva and Carlos Alberto Manssour Fraga*

Design, synthesis, and evaluation of isoquinoline ureas as TRPV1 antagonists

Volume:15
Nehaben A. Gujarati, Bradley J. Undem and Vijaya L. Korlipara*

Synthesis of Novel 8-Hydroxyquinoline Derivatives through Mannich Reaction and their Biological Evaluation as Potential Immunomodulatory Agents

Volume:15
Shaheen Faizia*, Tahira Sarfaraz, Saima Sumbul, Almas Jabeen, Sobia Ahsan Halim, Mohammad Ahmed Mesaik and Zaheer Ul-Haq

Thiazole Compounds as Antiviral Agents: An Update

Volume:15
Inder Pal Singh*, Shiv Gupta and Sanjay Kumar

New Serotoninergic Ligands Containing Indolic and Methyl Indolic Nuclei: Synthesis and in Vitro Pharmacological Evaluation

Volume:15
Elisa Magli, Beatrice Severino*, Angela Corvino, Elisa Perissutti, Francesco Frecentese, Irene Saccone, Flavia Giordano, Marian Castro, Josè Brea, Marian Isabel Loza, Vincenzo Santagada, Giuseppe Caliendo and Ferdinando Fiorino

Synthesis, Anticancer Activity on Prostate Cancer Cell Lines and Molecular Modeling Studies of Flurbiprofen-Thioether Derivatives as Potential Target of MetAP (type II)

Volume:15
ÖZGÜR YILMAZ, Burak Bayer, HATİCE BEKÇİ, Abdullah Ibrahim Uba, AHMET CUMAOĞLU, Kemal YELEKCI and S. GÜNİZ KÜÇÜKGÜZEL

2-Mercapto Benzothiazole Derivatives: As Potential Leads for the Diabetic Management

Volume:15
Saeed Ullah, Salma Mirza, Uzma Salar, Shafqat Hussain, Kulsoom Javaid, Khalid Mohammed Khan*, Ruqaiya Khalil, Atia Tul Wahab, Zaheer Ul-Haq, Shahnaz Perveen and M. Iqbal Choudhary

Synthesis, In vitro α-Glucosidase Inhibitory Potential and Molecular Docking Studies of 2-Amino-1,3,4-Oxadiazole Derivatives

Volume:15
Hayat Ullah, Fazal Rahim*, Muhammad Taha, Raffaqat Hussain, Abdul Wadood, Mohsan Nawaz, Zainul Wahab, Kanwal and Khalid Mohammed Khan

Synthesis and evaluation of glycyrrhetic acid-aromatic hybrids as anti-inflammatory agents

Volume:15
Zhi Chen, Shi-Chao Chen, Bo Li, Yong-An Yang and Jing Zhang*

Design, Synthesis and Evaluation of 8-Thiosubstituted 1,3,7-Trimethylxanthine Hydrazones with In Vitro Neuroprotective and MAO-B Inhibitory Activities

Volume:15
Javor Mitkov, Alexandra Kasabova-Angelova, Magdalena Kondeva-Burdina, Virginia Tzankova, Diana Tzankova, Maya Georgieva and Alexander Zlatkova*