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Current Drug Targets

Editor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Killing the Messenger: Antisense DNA and siRNA

Author(s): M. Nesterova and Y. S. Cho-Chung

Volume 5, Issue 8, 2004

Page: [683 - 689] Pages: 7

DOI: 10.2174/1389450043345137

Price: $65

Abstract

Among the technologies available for gene knockdown RNase H-dependent antisense oligonucleotides and RNAi are very popular. Both offer specificity and efficient knockdown of the genes; both are useful tools to study gene functions. Antisense and RNAi methods share many practical problems such as site selection, toxicity at high concentration, and the difficulty of transfection in certain cell types. We will focus in this review on the most important issues in the development of both methods and their possible use in gene-silencing therapy.

Keywords: gene therapy, gene silencing, oligonucleotides, antisense, rna interference


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